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991.
In this paper we scanned and summarized the empirical research evidence and found that the effects of pre-licensure interprofessional education on patient/client care are unknown. In contrast, for post-licensure collaboration interventions, there is a growing body of evidence suggesting positive effects on the delivery of care. The coverage of this latter evidence, however, is patchy, being especially weak in primary care. In interprofessional education, where policy level interventions have been value driven for the last half century, we have identified a base of evidence for the effectiveness of certain post-licensure collaboration interventions; this evidence is lacking for pre-licensure interprofessional education. If interventions and policies for both pre-licensure interprofessional education and post-licensure collaboration are implemented without accompanying rigorous evaluation research, we will remain mired in this same uncertainty into the future. 相似文献
992.
Sapieha PS Duplan L Uetani N Joly S Tremblay ML Kennedy TE Di Polo A 《Molecular and cellular neurosciences》2005,28(4):625-635
Recently, receptor protein tyrosine phosphatase-sigma (RPTPsigma) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS), central nervous system (CNS) neurons fail to regenerate their axons after injury or in disease. In order to assess the role of RPTPsigma in CNS regeneration, we used the retinocollicular system of adult mice lacking RPTPsigma to evaluate retinal ganglion cell (RGC) axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distally in optic nerves from RPTPsigma (-/-) mice compared to wild-type littermate controls. Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects. Furthermore, the time-course of RGC death after nerve lesion was not different between knockout and wild-type animals. Thus, enhanced axon regrowth in the absence of RPTPsigma could not be attributed to developmental defects or increased neuronal survival. Finally, we show constitutively elevated activity of mitogen-activated protein kinase (MAPK) and Akt kinase in adult RPTPsigma (-/-) mice retinas, suggesting that these signaling pathways may contribute to promoting RGC axon regrowth following traumatic nerve injury. Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS. 相似文献
993.
We describe a new type of caliper to optimize the size, shape, and centration of the capsulorhexis during intraocular lens (IOL) surgery. This flexible, ring-shaped tool is positioned on the anterior capsule surface, where it is kept in place by an ophthalmic viscosurgical device. When in place, the caliper provides an ideal guide for the surgeon to follow and facilitates optimal capsulorhexis shape and centration. 相似文献
994.
Théophile D Laure NE Benoît NT Anatole AG Emmanuel AA Paul TV Pierre K 《Inflammopharmacology》2006,14(1-2):42-47
Bridelia scleroneura is a member of the Euphorbiaceae family. In folk medicine in Cameroon, the stem bark of this plant is used for relieving
abdominal pain, contortion, arthritis and inflammation. In this study, the antinociceptive and anti-inflammatory activities
of the ethyl acetate stem bark extract have been evaluated. The putative analgesic effect of the plant extract was examined
in abdominal constriction, hot plate, formalin and on pain using tail immersion mouse models and in carrageenan-induced paw
edema in rats. The extract (150–600 mg/kg) exhibited a dose-dependent analgesic effect (46.27–78.97%) in acetic acid-induced
abdominal constriction in mice. B. scleroneura extract increased the pain latency of nociceptive response to thermal stimuli at the higher dose of 600 mg/kg. B. scleroneuna induced significant dose-dependent reduction of the nociception in both early and late phases of the formalin test. The extract
at the dose of 300 mg/kg, increased significantly, by 63.70% and 52.01% the tail-immersion latency time, 1 and 2 h post-dosing.
In the carrageenan test, B. scleroneura (150–600 mg/kg, p.o) had dose-dependent and significant effects at different time intervals. This behaviour was similar to
indometacin (10 mg/kg) used as a standard drug. These results show that the ethyl acetate stem bark extract of B. scleroneura possesses peripheral and central analgesic properties as well as anti-inflammatory activity against acute inflammation processes,
in support of the folk medicinal use of the plant. 相似文献
995.
The cellular immune response to hepatitis C virus (HCV) plays a critical role in determining the clearance or persistence of HCV. Moreover, in chronic HCV infection, these responses that are insufficient to eradicate virus completely may cause liver injury. In this study, the memory T cells responses specific to the core protein were measured by interferon-gamma Elispot assay after in vitro stimulation of peripheral blood mononuclear lymphocytes from chronically infected subjects. Ten out of the 22 patients studied (45%) present a core-specific response with a preferential recognition of the N-terminal and central parts. There was no relationship between T cell responses and the parameters of disease evolution as determined by ALT (serum alanine transaminase levels), and histologic hepatic damage (Metavir score A and F), but there was a positive relationship between the presence of a core-specific T cell responses and the viraemia. 相似文献
996.
Muriel de La Dure‐Molla Benjamin Philippe Fournier Maria Cristina Manzanares Ana Carolina Acevedo Raoul C. Hennekam Lisa Friedlander Marie‐Laure Boy‐Lefèvre Stephane Kerner Steve Toupenay Pascal Garrec Brigite Vi‐Fane Rufino Felizardo Marie‐Violaine Berteretche Laurence Jordan François Ferré François Clauss Sophie Jung Myriam de Chalendar Sebastien Troester Marzena Kawczynski Jessica Chaloyard International Group of Dental Nomenclature Marie Cécile Manière Ariane Berdal Agnès Bloch‐Zupan 《American journal of medical genetics. Part A》2019,179(10):1913-1981
Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification system was elaborated in the French collaborative network “TÊTECOU” and the affiliated O‐Rares reference/competence centers. The classification includes isolated and syndromic disorders with oral and dental anomalies, to which causative genes and main extraoral signs and symptoms are added. A systematic literature analysis yielded 408 entities of which a causal gene has been identified in 79%. We classified dental disorders in eight groups: dental agenesis, supernumerary teeth, dental size and/or shape, enamel, dentin, dental eruption, periodontal and gingival, and tumor‐like anomalies. We aim the classification to act as a shared reference for clinical and epidemiological studies. We welcome critical evaluations of the definitions and classification and will regularly update the classification for newly recognized conditions. 相似文献
997.
998.
Penélope Esther Palominos Laura Coates Charles Lubianca Kohem Ana-Maria Orbai Josef Smolen Maarten de Wit Uta Kiltz Ying-Ying Leung Juan D. Cañete Rossana Scrivo Andra Balanescu Emmanuelle Dernis Sandra Meisalu Martin Soubrier Sibel Zehra Aydin Inna Gaydukova Umut Kalyoncu Laure Gossec 《Revue du Rhumatisme》2021,88(3):201-207
999.
1000.
Kuanrong Li Garnet Anderson Vivian Viallon Patrick Arveux Agnès Fournier Vittorio Krogh Rosario Tumino Maria-Jose Sánchez Eva Ardanaz María-Dolores Chirlaque Antonio Agudo David C. Muller Todd Smith Ioanna Tzoulaki Timothy J. Key Bas Bueno-de-Mesquita Christina Bamia Philippos Orfanos Rudolf Kaaks Anika Hüsing Renée T. Fortner Anne Zeleniuch-Jacquotte Christina C. Dahm Kim Overvad Dagfinn Aune Elisabete Weiderpass Elio Riboli Marc J. Gunter Laure Dossus Ross Prentice Pietro Ferrari 《Breast cancer research : BCR》2018,20(1):147