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121.
Exercise-induced left bundle branch block(EI-LBBB)is infrequent phenomenon.We present two patients with angina pectoris who developed EI-LBBB during exercise tolerance test.The first patient with typical angina pectoris had significant obstructive coronary artery disease(CAD)requiring percutaneous coronary intervention of multiple lesions including placement of drug eluting stents.The second patient had atypical chest pain without signs of CAD at all.EI-LBBB occurred at a heart rate of 80 bpm and 141 bpm in the first and second patient,respectively.EI-LBBB remained visible through the test till the recovery period in the first patient at a heart rate of 83 bpm and disappeared at 96bpm in the second patient.Both patients with this infrequent phenomenon are discussed and the literature is reviewed. 相似文献
122.
Samantha M Zunich Taneka Douglas Maria Valdovinos Tiffany Chang Wade Bushman David Walterhouse Philip Iannaccone Marilyn LG Lamm 《Molecular cancer》2009,8(1):12-11
Background
Sonic hedgehog (Shh) and components of its signalling pathway have been identified in human prostate carcinoma and increased levels of their expression appear to correlate with disease progression and metastasis. The mechanism through which Shh signalling could promote metastasis in bone, the most common site for prostate carcinoma metastasis, has not yet been investigated. The present study determined the effect of Shh signalling between prostate cancer cells and pre-osteoblasts on osteoblast differentiation, a requisite process for new bone formation that characterizes prostate carcinoma metastasis. 相似文献123.
Breast metastases from extramammary malignancies 总被引:2,自引:0,他引:2
124.
鲜罗汉果中黄酮甙的分离及结构测定 总被引:12,自引:0,他引:12
A new flavonol glycoside named grosvenorine and a known compoundwere isolated from the fresh fruits of Siraitia grosvenori( swingle)C. By means of UV,FAB-MS,1H-1H COSY,13C-1H COSY and NOE difference ,spectra,the structure of grosvenorinewas established as kaempferol-3-O-α-L-rhafmnopyranoside-7-O[β-D-glucopyranosyl-(1-2)-α-L-rhamnopyranoside].The known compound was identified as kaempferol-3,7-α-L-dirhamnopyra-noside. 相似文献
125.
Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI 总被引:1,自引:0,他引:1
Chang S; Rosenberg MJ; Morton H; Francomano CA; Biesecker LG 《Human molecular genetics》1998,7(5):865-870
Glycogen storage disease type VI (GSD6) defines a group of disorders that
cause hepatomegaly and hypoglycemia with reduced liver phosphorylase
activity. The course of these disorders is generally mild, but definitive
diagnosis requires invasive procedures. We analyzed a Mennonite kindred
with an autosomal recessive form of GSD6 to determine the molecular defect
and develop a non-invasive diagnostic test. Linkage analysis was performed
using genetic markers flanking the liver glycogen phosphorylase gene ( PYGL
), which was suspected to be the cause of the disorder on biochemical
grounds. Mennonite GSD6 was linked to the PYGL locus with a multipoint LOD
score of 4.7. The PYGL gene was analyzed for mutations by sequencing
genomic DNA. Sequencing of genomic DNA revealed a splice site abnormality
of the intron 13 splice donor. Confirmation of the genomic mutation was
performed by sequencing RT-PCR products, which showed heterogeneous PYGL
mRNA lacking all or part of exon 13 in affected persons. This study is the
first to demonstrate that a mutation in the PYGL gene can cause GSD6. This
mutation is estimated to be present on 3% of Mennonite chromosomes and the
disease affects 0.1% of that population. Determination of this mutation
provides a basis for the development of a simple and non- invasive
diagnostic test for the disease and the carrier state in this population
and confirms biochemical data showing the importance of this gene in
glucose homeostasis.
相似文献
126.
127.
辽吉冰凉花总甙对心功能影响的实验研究 总被引:4,自引:0,他引:4
辽吉冰凉花总甙(APAW)1.0mg/kg iv,能使麻醉家兔正常心脏的P-dP/dt环体面积(LO),LV-dP/dt_(max),Vpm及LVSP比药前增大,HR减慢。APAW和冰凉花(AAR)及毒毛旋花子甙K(SK)一样,能明显改善衰竭兔心的心功能。静脉恒速输入0.5 mg/ml APAW,25min后,心衰家兔的LVSP,LV—dP/dt max,LO均明显回升,LVEDP降低,t-dP/dt max缩短。三种强心甙的最大强心效力无显著性差异。但APAW的治疗宽度和治疗指数均较AAR和SK为大,而AAR和SK间则无显著性差异。 相似文献
128.
Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis 总被引:10,自引:1,他引:9
Ohmen JD; Yang HY; Yamamoto KK; Zhao HY; Ma Y; Bentley LG; Huang Z; Gerwehr S; Pressman S; McElree C; Targan S; Rotter JI; Fischel-Ghodsian N 《Human molecular genetics》1996,5(10):1679-1683
In the Western world, chronic inflammatory bowel disease (IBD) presents as
two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC)
[Targan, S.R. and Shanahan, F. (1994). In Retford, D.C (ed.), Inflammatory
Bowel Disease: From Bench to Bedside. Williams and Wilkins, Baltimore].
Genetic epidemiological studies, the occurrence of rare syndromes
associated with IBD, and animal models suggest that inherited factors play
significant roles in the susceptibility to both forms of IBD [Yang, H.-Y.
and Rotter, J.I. (1995) In Kirsner, J.B. and Shorter, R.G. (eds). Genetic
Aspects of Idiopathic Inflammatory Bowel Disease. Williams and Wilkins,
Baltimore, pp.301-331]. Recently, a genome-wide search on European families
with multiple affected members with CD identified a putative susceptibility
locus in the centromeric region of chromosome 16 [Hugot, J.-P. et al.
(1996) Nature, 379, 821- 823]. We have now tested this region in an
independent set of US families, confirmed that this region is likely to
contain a gene predisposing to CD, and further refined the chromosomal
location of this gene. Most importantly with respect to this locus, our
data also seem to indicate that there is heterogeneity both within the CD
group, and between the CD and UC groups with respect to this locus. The
susceptibility locus appears to be involved only in non-Jewish CD sibpairs
and not in our Ashkenazi Jewish CD sibpairs. Additionally, we have tested
sibpairs having either only UC or both UC and CD for involvement of this
locus, and have found no evidence that this region predisposes to IBD in
these patients.
相似文献
129.
Avascular necrosis of the vertebral body: MR imaging 总被引:14,自引:0,他引:14
Five patients with plain radiographic evidence of a compressed vertebra containing an intravertebral vacuum cleft indicative of avascular necrosis underwent magnetic resonance (MR) imaging. In these patients, the T2-weighted images revealed a distinct appearance consisting of marked and discrete hyperintensity at the location of the intravertebral cleft. T1-weighted images were hypointense in this region. Recognition of this pattern is important in the MR imaging evaluation of compression fractures of the vertebral body so that confusion with malignancy or infection may be avoided, thereby obviating additional diagnostic studies. 相似文献
130.