全文获取类型
收费全文 | 299277篇 |
免费 | 8740篇 |
国内免费 | 1129篇 |
专业分类
耳鼻咽喉 | 3079篇 |
儿科学 | 8454篇 |
妇产科学 | 4878篇 |
基础医学 | 36603篇 |
口腔科学 | 4662篇 |
临床医学 | 24050篇 |
内科学 | 53037篇 |
皮肤病学 | 4705篇 |
神经病学 | 26566篇 |
特种医学 | 16055篇 |
外科学 | 44987篇 |
综合类 | 2830篇 |
现状与发展 | 3篇 |
一般理论 | 27篇 |
预防医学 | 24573篇 |
眼科学 | 5952篇 |
药学 | 20264篇 |
中国医学 | 2122篇 |
肿瘤学 | 26299篇 |
出版年
2023年 | 677篇 |
2022年 | 2697篇 |
2021年 | 4506篇 |
2020年 | 2159篇 |
2019年 | 3038篇 |
2018年 | 25150篇 |
2017年 | 19963篇 |
2016年 | 22945篇 |
2015年 | 6440篇 |
2014年 | 7382篇 |
2013年 | 8462篇 |
2012年 | 18225篇 |
2011年 | 31450篇 |
2010年 | 24636篇 |
2009年 | 16558篇 |
2008年 | 26682篇 |
2007年 | 28472篇 |
2006年 | 7058篇 |
2005年 | 8207篇 |
2004年 | 8595篇 |
2003年 | 8866篇 |
2002年 | 6403篇 |
2001年 | 3302篇 |
2000年 | 3209篇 |
1999年 | 2294篇 |
1998年 | 1114篇 |
1997年 | 877篇 |
1996年 | 599篇 |
1995年 | 558篇 |
1994年 | 487篇 |
1993年 | 392篇 |
1992年 | 789篇 |
1991年 | 782篇 |
1990年 | 761篇 |
1989年 | 632篇 |
1988年 | 517篇 |
1987年 | 505篇 |
1986年 | 359篇 |
1985年 | 398篇 |
1984年 | 283篇 |
1983年 | 212篇 |
1982年 | 161篇 |
1981年 | 168篇 |
1980年 | 168篇 |
1979年 | 224篇 |
1978年 | 170篇 |
1976年 | 144篇 |
1975年 | 125篇 |
1974年 | 159篇 |
1973年 | 122篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
991.
Fredrik Ghosh Karl Engelsberg Robert V. English Robert M. Petters 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(6):835-846
Background The purpose of this study was to explore neuroretinal transplantation in a large animal model of severe retinitis pigmentosa
and to establish graft development, long-term survival, graft-host integration, and effects on the host retina.
Methods Rhodopsin transgenic pigs, aged 6 months, received in one eye a fetal full-thickness neuroretinal sheet in the subretinal
space by means of vitrectomy and retinotomy. Six months postoperatively, eyes were studied in the light microscope and with
immunohistochemical markers. Full-field electroretinography (ERG) was performed at 4 and 6 months.
Results Laminated grafts with well-organized photoreceptors, rod bipolar cells, and Müller cells were found in five of six eyes. Neuronal
connections between graft and host retina were not seen. In the five eyes containing a graft, the number of surviving rods
in the host retina was significantly higher compared with unoperated eyes. The ERG did not reveal any significant difference
in b-wave amplitude between operated and control eyes, but the cone-derived response in operated eyes increased significantly
from 4 to 6 months while the rod response in control eyes decreased significantly.
Conclusions Fetal full-thickness neuroretina can be transplanted safely to an eye with severe retinal degeneration. In their major part,
the transplants develop a normal laminated morphology and survive for at least 6 months. Graft and host retinal neurons do
not form connections. Retinal function in the host is reduced initially by the surgical trauma, but the presence of a well-laminated
graft counteracts this effect and rescues rods from degeneration.
Supported by The Foundation Fighting Blindness (grant# C-NC02-798-0078), The Faculty of Medicine, University of Lund, The
Swedish Research Council, The Princess Margaretas Foundation for Blind Children, The 2nd ONCE International Award for New
Technologies for the Blind. 相似文献
992.
993.
Antonio Fea Andrea Grosso Marilena Rabbione Federico Grignolo 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(2):315-317
Background Optic disc anomalies are frequently associated with Alagille syndrome. We report here the first case of a patient with Alagille
syndrome combined with optic pit and serous macular detachment.
Methods A male patient with Alagille syndrome was referred from the pediatric hepatology department for investigation of visual loss
in the right eye. Anterior segment examination showed evidence of posterior embryotoxon, confirmed by gonioscopic evaluation.
Dilated fundus examination revealed serous macular detachment and optic pit.
Results OCT 3 scans confirmed the clinical findings.
Conclusions Optic pit is uncommon and should prompt a search for genetic disorders or development abnormalities. The association between
the two syndromes in this patient might be due to failure of correct neuroectodermal development, for which a common genetic
pathway is likely. 相似文献
994.
Background
January 1, 2002, copayment for outpatient female sterilization in Norwegian public hospitals increased from 33 euros to 750 euros after a revision of the health care system. The aim of the present study was to investigate the effect of the new copayment system on female sterilization epidemiology. 相似文献995.
Peter Christian Ruokonen Thomas Schwenteck Jörg Draeger 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(9):1259-1265
BACKGROUND: Two new tonometers have been introduced that are based on the impedance principle. Both the TGDc-01 (transpalpebral measurement) and the iCare (corneal measurement) do not require corneal anaesthesia. The present work presents an evaluation of both devices. METHODS: Comparative measurements using one of the new tonometers and applanation tonometry were performed by one investigator according to the international standard for ocular tonometer (ISO 8612). Measurements were performed on 445 eyes without corneal pathology from 243 patients. Six measurements were performed for iCare and 3 for TGDc, immediately followed by 3 applanation tonometry measurements. RESULTS: The correlation coefficient with respect to applanation tonometry was 0.81 for TGDc and 0.95 for iCare. TGDc-01 measurements showed an average deviation of 3.1 +/- 2.6 mmHg to those of Perkins applanation tonometry. The maximum difference was 28.7 mmHg below and 9.8 mmHg above the results of applanation tonometry. iCare showed an average deviation of 2.5 +/- 1.1 mmHg to Goldmann tonometry. The maximum difference was 14.5 mmHg below and 9.8 mmHg above. CONCLUSIONS: The results of both new tonometers showed a good correlation with the reference applanation tonometric methods, but the strict requirements of ISO 8612 are not fulfilled by either tonometer at present. Additionally, transpalpebral measurements with the TGDc-01 showed unacceptably high variability. 相似文献
996.
997.
Claudia KY Lai 《BMC nursing》2007,6(1):5
Background
To date, the literature has provided an abundance of evidence on the adverse outcomes of restraint use on patients. Reportedly, nurses are often the personnel who initiate restraint use and attribute its use to ensuring the safety of the restrained and the others. A clinical trial using staff education and administrative input as the key components of a restraint reduction program was conducted in a rehabilitation setting to examine whether there were any significant differences in the prevalence of restraint use pre- and post-intervention. Subsequent to the implementation of the intervention program, focus group interviews were conducted to determine the perspective of the nursing staff on the use of restraints and their opinions of appropriate means to reduce their use. 相似文献998.
999.
1000.