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91.
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation 总被引:1,自引:0,他引:1
Saito T Tsuchiya M Shikata C Yamaguchi H Miyata S Matsuo S Ishizawa S Yoshimura K 《Internal medicine (Tokyo, Japan)》2003,42(9):850-855
A 57-year-old woman was admitted to our hospital because of severe dyspnea due to pulmonary hemorrhage and rapidly progressive renal failure. The patient was positive for perinuclear pattern anti-neutrophil cytoplasmic antibody (p-ANCA) and was manifested with gastrointestinal bleeding and brain hemorrhage. Thus, she was diagnosed as having microscopic polyangiitis (MPA). Laboratory examination demonstrated severe thrombocytopenia, increased prothrombin time and a high concentration of fibrin degradation products. In addition, the elevated plasma levels of D-dimer, thrombin-antithrombin complex and plasmin-plasmin inhibitor complex led us to make a diagnosis of disseminated intravascular coagulation (DIC). Complication of DIC was considered to have caused further deterioration in bleeding tendency due to MPA in the present case. The patient was treated with plasma exchange, hemodialysis, administration of corticosteroid including pulse therapy and cyclophosphamide. Continuous infusion of gabexate mesilate proved effective for improvement of systemic bleeding tendency. However, she finally died of severe infectious diseases. In conclusion, it is suggested that ANCA-associated vasculitis could be accompanied by DIC and gabexate mesilate may be a useful therapeutic agent for these disorders. 相似文献
92.
Daisuke Hasegawa Ryota Sato Narut Prasitlumkum Kazuki Nishida Kunihiko Takahashi Tomoaki Yatabe Osamu Nishida 《Chest》2021,159(6):2289-2300
93.
Globoid Cell Leucodystrophy (Krabbe''s Disease): Deficiency of Galactocerebroside β-Galactosidase 下载免费PDF全文
Kunihiko Suzuki Yoshiyuki Suzuki 《Proceedings of the National Academy of Sciences of the United States of America》1970,66(2):302-309
Profound deficiency of a specific enzyme, galactocerebroside beta-galactosidase, has been demonstrated in the brains, liver, and spleen of three patients with Krabbe's globoid cell leucodystrophy. The activity of this enzyme was normal in a variety of other cerebral diseases, including those with similarly devasted white matter. The lack of enzyme activity was not due to an inhibitor in the tissue, nor is it due to a shift in the pH optimum. The deficiency of galactocerebroside beta-galactosidase as the primary enzymatic defect can account for the morphological and biochemical characteristics of this disease better than the previously reported deficiency of cerebroside-sulfatide sulfotransferase. 相似文献
94.
Tokio Wakabayashi Hideo Morimoto Kunihiko Suzuki Sen Tanabe Hiroshi Kida Goro Sugioka Mutsuyuki Kinoshita Norio Sawabu 《Journal of gastroenterology》1994,29(5):656-660
An aberrant hepatic duct directly connected to the main pancreatic duct with anomalous arrangement of the pancreato-biliary ductal system is reported here, the first report of such a case, to our knowledge. A 53-year-old woman was admitted to our hospital because of cholecystolithiasis with abdominal pain in the right upper quadrant. Endoscopic retrograde cholangiopancreatography (ERCP) showed that an aberrant hepatic duct, which independently drained the right posterior segment of the liver, connected to the main pancreatic duct at a high insertion site distal to the sphincter area of the major papilla. The common bile duct (containing stones), on the other hand, united with the main pancreatic duct in a normal fashion. Cholecystectomy and bile duct lithotomy were performed. The aberrant hepatic duct was separated from the main pancreatic duct just above the junction, and was anastomosed side-by-side to the common hepatic duct. The embryologic development of this lesion is not clear, but is discussed in this report. 相似文献
95.
96.
Pinós Tomàs Fuku Noriyuki Cámara Yolanda Arai Yasumichi Abe Yukiko Rodríguez-Romo Gabriel Garatachea Nuria Santos-Lozano Alejandro Miro-Casas Elisabet Ruiz-Meana Marisol Otaegui Imanol Murakami Haruka Miyachi Motohiko Garcia-Dorado David Hinohara Kunihiko Andreu Antoni L. Kimura Akinori Hirose Nobuyoshi Lucia Alejandro 《Age (Dordrecht, Netherlands)》2014,36(2):933-943
GeroScience - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery... 相似文献
97.
98.
Nakaichi Tetsu Yamashita Shozo Kawakami Wataru Yamamoto Haruki Sasaki Masayuki Yokoyama Kunihiko 《Annals of nuclear medicine》2020,34(8):583-594
Annals of Nuclear Medicine - This study aimed to evaluate the accuracy of six threshold-based segmentation methods with different target-to-background ratios (TBR), images with different voxel... 相似文献
99.
Masanori Atsukawa Akihito Tsubota Hidenori Toyoda Koichi Takaguchi Makoto Nakamuta Tsunamasa Watanabe Kojiro Michitaka Tadashi Ikegami Akito Nozaki Haruki Uojima Shinya Fukunishi Takuya Genda Hiroshi Abe Naoki Hotta Kunihiko Tsuji Chikara Ogawa Yoshihiko Tachi Toshihide Shima Noritomo Shimada Chisa Kondo Takehiro Akahane Yoshio Aizawa Yasuhito Tanaka Takashi Kumada Katsuhiko Iwakiri 《Alimentary pharmacology & therapeutics》2019,49(9):1230-1241
100.
Masayuki Shintaku Nao Toyooka Takashi Koyama Shunsuke Teraoka Mitsuru Tsudo 《Neuropathology》2014,34(6):547-553
The patient was a 70‐year‐old woman with lymphoplasmacytic lymphoma which showed a predominantly diffuse involvement of the bone marrow and kidney. Because atypical lymphocytes appeared in the cerebrospinal fluid, the intrathecal administration of methotrexate (MTX) and cytosine arabinoside (Ara‐C) was repeated several times. The patient developed flaccid paraplegia 8 months after the beginning of intrathecal administration, and died 4 months later. Autopsy demonstrated extensive transverse necrosis involving the lower thoracic cord and marked vacuolar degeneration of the white matter of the cervical, upper thoracic and lumbo‐sacral cord. Focal vacuolar degeneration of the white matter was also noted in the left parietal lobe. Although vacuolar degeneration of the white matter is a common feature in MTX myelopathy, extensive transverse necrosis is rare. In the present case, an overlapping of two mechanisms, that is, injury of vascular endothelial cells and the direct toxic effect of MTX and Ara‐C on the white matter, probably played a crucial role in the pathogenesis of severe myelopathy. Because severe myelopathy occurs infrequently, considering the large number of patients receiving the intrathecal administration of MTX, it is possible that a constitutional predisposition or abnormal sensitivity to MTX was involved in the pathogenesis in the present patient. 相似文献