全文获取类型
收费全文 | 3385篇 |
免费 | 206篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 72篇 |
妇产科学 | 70篇 |
基础医学 | 425篇 |
口腔科学 | 68篇 |
临床医学 | 227篇 |
内科学 | 977篇 |
皮肤病学 | 29篇 |
神经病学 | 221篇 |
特种医学 | 81篇 |
外科学 | 550篇 |
综合类 | 5篇 |
预防医学 | 108篇 |
眼科学 | 32篇 |
药学 | 311篇 |
中国医学 | 2篇 |
肿瘤学 | 408篇 |
出版年
2023年 | 63篇 |
2022年 | 126篇 |
2021年 | 202篇 |
2020年 | 101篇 |
2019年 | 111篇 |
2018年 | 144篇 |
2017年 | 85篇 |
2016年 | 117篇 |
2015年 | 101篇 |
2014年 | 116篇 |
2013年 | 158篇 |
2012年 | 213篇 |
2011年 | 207篇 |
2010年 | 117篇 |
2009年 | 74篇 |
2008年 | 186篇 |
2007年 | 176篇 |
2006年 | 137篇 |
2005年 | 135篇 |
2004年 | 112篇 |
2003年 | 111篇 |
2002年 | 85篇 |
2001年 | 56篇 |
2000年 | 59篇 |
1999年 | 69篇 |
1998年 | 25篇 |
1997年 | 16篇 |
1996年 | 22篇 |
1995年 | 24篇 |
1994年 | 14篇 |
1993年 | 21篇 |
1992年 | 50篇 |
1991年 | 36篇 |
1990年 | 28篇 |
1989年 | 30篇 |
1988年 | 31篇 |
1987年 | 31篇 |
1986年 | 31篇 |
1985年 | 30篇 |
1984年 | 15篇 |
1983年 | 15篇 |
1982年 | 10篇 |
1979年 | 15篇 |
1976年 | 8篇 |
1973年 | 10篇 |
1971年 | 12篇 |
1970年 | 12篇 |
1969年 | 11篇 |
1968年 | 8篇 |
1967年 | 8篇 |
排序方式: 共有3628条查询结果,搜索用时 15 毫秒
81.
Usefulness of sonourethrography for penile abscess as a result of xanthogranulomatous granuloma in the corpus cavernosum of an adult: A case report 下载免费PDF全文
Tomonori Minagawa Haruaki Kato Teruyuki Ogawa Takeshi Uehara Osamu Ishizuka 《International journal of urology》2015,22(8):788-790
A 75‐year‐old man presented with a 4‐month history of a swollen and painful penis. Computed tomography showed a round‐shaped mass measuring 3 × 2 cm in the corpus cavernosum. Percutaneous drainage of the penile mass was carried out and a course of antibiotics was prescribed. Viral, fungal and selective bacterial cultures were negative. Total penectomy and urethroperineal fistula formation were carried out because of penile pain. Histopathological diagnosis was xanthogranulomatous granuloma of the corpus cavernosum. Before surgery, sonourethrography was carried out under general anesthesia. Sonourethrography is an infrequently used modality to observe the male urethra under urinary micturition or injection of saline. We previously reported modified sonourethrography with retrograde jelly injection. In the present case, sonourethrography successfully showed the damaged and deformed urethra including the abscess cavity and fistula. Although xanthogranulomatous granuloma is rare, the findings reported here showed the usefulness of sonourethrography for morphological evaluation of the male urethra. 相似文献
82.
83.
84.
Kosuke Okuwaki Hironori Masutani Hiroshi Imaizumi Tsutomu Yoshida Mitsuhiro Kida Tomohisa Iwai Hiroshi Yamauchi Masayoshi Tadehara Kai Adachi Masafumi Watanabe Takahiro Kurosu Wasaburo Koizumi 《Pancreatology》2019,19(3):419-423
Background/Objectives
A breakthrough in chemotherapy for pancreatic ductal adenocarcinoma (PDAC) may be achieved using precision medicine, which involves identifying cases that are highly likely to respond to a certain treatment and then performing that treatment. BRCAness has been receiving attention as a novel predictor of anticancer drug sensitivity in PDAC, making the screening of BRCAness paramount.Methods
We conducted the first-ever examination of the feasibility of analyzing BRCAness using multiplex ligation-dependent probe amplification (MLPA). Formalin-fixed paraffin-embedded (FFPE) tissue samples obtained via endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) from 20 patients with the highest pancreatic carcinoma cell counts in tissue samples out of 40 consecutive PDAC patients who underwent EUS-FNAB at our hospital were analyzed by MLPA for BRCAness.Results
We were able to accurately analyze BRCAness in 75% of the 20 cases of PDAC using FFPE tissue obtained by EUS-FNAB. BRCAness was observed in one of the 20 cases.Conclusions
In PDAC, analyzing BRCAness by MLPA using FFPE tissue obtained by EUS-FNAB offers the remarkable benefit of yielding results in a short period of time and at a low cost. In addition, this method of BRCAness analysis may prove to be a feasible and effective approach for performing precision medicine. 相似文献85.
86.
Mitani Genya Takagaki Tomonori Hamahashi Kosuke Serigano Kenji Nakamura Yutaka Sato Masato Mochida Joji 《Journal of orthopaedic surgery and research》2015,10(1):1-6
Growth factors such as nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the healing process of nerve injury. Recent researches have also shown that oxytocin administration activates these growth factors of importance for the healing of nerve tissue. The objective of the present study was to evaluate the effects of oxytocin on peripheral nerve regeneration in rats. Twenty-four male Sprague-Dawley rats were underwent transection damage model on the right sciatic nerve and defective damage model on the left sciatic nerve. The animals were assigned to one of two groups: control group or treatment group (received 80 mg/kg oxytocin intraperitoneally for 12 weeks). The sciatic nerve was examined, both functionally (on the basis of climbing platform test) and histologically (on the basis of axon count), 3, 6, 9, and 12 weeks after the injury. Also, stereomicroscopic and electrophysiological evaluations were carried out. Significantly greater improvements in electrophysiological recordings and improved functional outcome measures were presented in the treatment group at 12-week follow-up. Stereomicroscopic examinations disclosed prominent increases in vascularization on proximal cut edges in the oxytocin group in comparison with the control group. Higher axon counts were also found in this group. Intraperitoneal oxytocin administration resulted in accelerated functional, histological, and electrophysiological recovery after different sciatic injury models in rats. 相似文献
87.
Dr. Yoshio Miura MD Yoshitaka Kato MD Rokuro Seiko MD Mari Nomura MD Kosuke Yamane MD Koichi Fujikawa MD Toshiyuki Iwamoto MD Kiyohiko Dohi MD 《Digestive diseases and sciences》1992,37(10):1619-1623
Summary A case of pancreatic arteriovenous malformation (AVM) with hepatocellular carcinoma is reported. The patient, a 56-year-old Japanese man, was asymptomatic. The pancreatic lesion was found incidentally during an evaluation for hepatocellular carcinoma. Celiac arteriogram demonstrated tortuous feeding arteries, a racemose intrapancreatic stain, which disappeared before the venous phase, and early portal filling. 相似文献
88.
89.
Miku Nakagawa Riko Kitazawa Takeshi Kondo Kosuke Ninomiya Masayoshi Okita Ryuma Haraguchi Sohei Kitazawa 《Virchows Archiv : an international journal of pathology》2014,464(3):253-256
Duodenal gastric heterotopia (DGH) is a benign asymptomatic condition assumed to be of congenital origin. Since DGH is often associated with fundic gland polyps (FGPs) that frequently carry a somatic β-catenin gene mutation, we examined whether DGH, either sporadic or FGP-associated, is attributable to alterations of the Wnt/β-catenin pathway. Genetic analysis revealed frequent somatic β-catenin gene mutations in DGH; some of which showed the same mutation pattern as coexisting FGPs. All missense mutations were confined to codons 32, 33, and 37. No such mutations were observed, however, in any of the specimens from focal gastric foveolar metaplasia (GFM). Therefore, DGH is not a mere congenital lesion due to aberrant migration of normal gastric mucosa or a simple reactive metaplasia after regenerative stimuli of the duodenal mucosa, but a distinct condition based upon molecular genetic changes in the Wnt/β-catenin pathway. 相似文献
90.
Kosuke Minaga Mamoru Takenaka Kentaro Yamao Ken Kamata Shunsuke Omoto Atsushi Nakai Tomohiro Yamazaki Ayana Okamoto Rei Ishikawa Tomoe Yoshikawa Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo 《World journal of gastroenterology : WJG》2020,26(9):947-959
BACKGROUND Although several techniques for endoscopic ultrasound-guided biliary drainage(EUS-BD)are available at present,an optimal treatment algorithm of EUS-BD has not yet been established.AIM To evaluate the clinical utility of treatment method conversion during single endoscopic sessions for difficult cases in initially planned EUS-BD.METHODS This was a single-center retrospective analysis using a prospectively accumulated database.Patients with biliary obstruction undergoing EUS-BD between May 2008 and April 2016 were included.The primary outcome was to evaluate the improvement in EUS-BD success rates by converting the treatment methods during a single endoscopic session.Secondary outcomes were clarification of the factors leading to the conversion from the initial EUS-BD and the assessment of efficacy and safety of the conversion as judged by technical success,clinical success,and adverse events(AEs).RESULTS A total of 208 patients underwent EUS-BD during the study period.For 18.8%(39/208)of the patients,the treatment methods were converted to another EUSBD technique from the initial plan.Biliary obstruction was caused by pancreatobiliary malignancies,other malignant lesions,biliary stones,and other benign lesions in 22,11,4,and 2 patients,respectively.The reasons for the difficulty with the initial EUS-BD were classified into the following 3 procedures:Target puncture(n=13),guidewire manipulation(n=18),and puncture tract dilation(n=8).Technical success was achieved in 97.4%(38/39)of the cases and clinical success was achieved in 89.5%of patients(34/38).AEs occurred in 10.3%of patients,including bile leakage(n=2),bleeding(n=1),and cholecystitis(n=1).The puncture target and drainage technique were altered in subsequent EUSBD procedures in 25 and 14 patients,respectively.The final technical success rate with 95%CI for all 208 cases was 97.1%(95%CI:93.8%-98.9%),while that of the initially planned EUS-BD was 78.8%(95%CI:72.6%-84.2%).CONCLUSION Among multi-step procedures in EUS-BD,guidewire manipulation appeared to be the most technically challenging.When initially planned EUS-BD is technically difficult,treatment method conversion in a single endoscopic session may result in successful EUS-BD without leading to severe AEs. 相似文献