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111.
David H Peters Manish Kohli Maya Mascarenhas Krishna Rao 《International journal for quality in health care》2006,18(6):437-445
OBJECTIVE: The objective was to test whether a decision support technology for non-physicians can increase health care utilization and quality. DESIGN: Before and after measurements were taken from a systematic random sample of patients and staff at randomly assigned intervention and control facilities. SETTING: The study took place at primary health facilities in rural Tamil Nadu, India. PARTICIPANTS: One thousand two hundred and eighty-six patients and 82 staff were interviewed. INTERVENTION: A computer-assisted decision support technology was introduced to assist with patient screening. MAIN OUTCOME MEASURES: Outcome measures included new patient visits per month, a Global Patient Assessment of Care Index, and health worker attitude variables. RESULTS: There was a difference of difference of 430 new patient visits per month at the intervention sites (P = 0.005), an increase from baseline of 18% at intervention sites compared with a decline of 5% at control sites. The intervention was associated with significant improvements in a Global Patient Assessment of Care Index (mean difference of difference 7.9, P < 0.001). The largest gains were made in patient communication, technical quality, and general satisfaction with care. The attitudes of public health workers toward the new technology and their jobs did not change. CONCLUSIONS: Decision support technologies have considerable potential to improve coverage and quality of health care for the poor and where there is no doctor, but the unreceptive attitude of public health workers would need to be overcome. Application of these technologies should take advantage of their popularity with patients and the opportunity to work through the private sector. 相似文献
112.
Gupta S Seith A Sud K Kohli HS Singh SK Sakhuja V Suri S 《Acta radiologica (Stockholm, Sweden : 1987)》2000,41(3):280-284
Purpose: We retrospectively reviewed the CT findings in 24 cases of autosomal dominant polycystic kidney disease (ADPKD) to assess the role of CT in the diagnostic work-up of patients with complicated ADPKD.Material and Methods: Twenty-four patients with ADPKD underwent unenhanced and contrast-enhanced CT for flank pain, haematuria, or fever. The images were retrospectively reviewed for presence of complicated cysts, their morphological features and associated findings in the perinephric space/retroperitoneum.Results: Cyst haemorrhage was present in all patients, seen as high-density cysts, which were mostly bilateral. Most of these cysts had sharply outlined contours, sharp interfaces with adjacent renal parenchyma, imperceptible walls, and homogeneous density, and did not enhance following i.v. contrast administration. However, a few haemorrhagic cysts (9 cysts in 6 patients) showed inhomogeneous density (n=7), dependent layering of high-density blood leading to fluid-fluid level (n=2), and contour irregularity (n=3).CT revealed presence of cyst infection in 6 cases; the involved cysts were larger (average size 4.2 cm) than adjacent cysts, had only a mildly increased or near water density, and showed wall thickening and enhancement. Other findings included air within the infected cyst (n=1), thickening and enhancement of peri- and paranephric fasciae (n=5), and abscesses in the posterior paranephric space and adjoining psoas muscle (n=2). In 2 other patients, although CT suggested cyst infection because of presence of wall enhancement, diagnostic needle aspiration revealed only sterile haemorrhagic fluid. In 1 case, CT revealed a soft tissue density enhancing mass in one of the cysts; this proved to be a renal cell carcinoma by fine-needle biopsy. Calculi were observed in 7 patients, and cyst wall calcification in 11 cases.Conclusion: A combination of unenhanced and contrast-enhanced CT allows correct diagnosis and differentiation amongst the various complications affecting patients with ADPKD. However, in a small subgroup of patients, it may not be possible to differentiate between haemorrhage and infection; such cases require diagnostic needle aspiration for diagnosis. 相似文献
113.
114.
Mucormycosis is a rare fungal infection of childhood, occurring mainly in
patients with chronic illnesses such as diabetes and malignancies. The
fungus seldom grows in culture and confirmation of the diagnosis depends on
histologic examination of infected tissues. To date, the reported natural
history of the disease has been rapid progression and a fatal outcome.
Therefore, the importance of early diagnosis by tissue biopsy and early
treatment with surgical debridement and systemic antifungal therapy cannot
be overemphasized. The pulmonary system is the most common site for
mucormycosis in patients with leukemia. We report what we believe to be the
first successfully treated case of isolated muscular mucormycosis occurring
in a child with biphenotypic acute leukemia. The diagnosis was made
promptly by tissue examination at the time of surgical debridement. The
patient was also given systemic amphotericin-B therapy.
相似文献
115.
B. C. Chhaparwal G. Kohli J. N. Pohowalla S. D. Singh 《Indian journal of pediatrics》1971,38(5):241-245
Summary Magnesium levels in the serum and in the C.S.F. in 100 children presenting with febrile convulsions were determined. This
was repeated in 36 children after 2 weeks, of which 23 could be re-examined after a further period of 2 weeks. Nearly one-half
of the cases on admission had magnesium levels in the serum lower than the average observed in normal children in this region
and in over two-thirds of the cases the levels in the C.S.F. were lower than the average in the same region. The C.S.F. magnesium
levels rose after 2–4 weeks. This was not found in the case of serum levels.
These findings bear out the suggestion made in a pervious communication that there is some aetiological relationship between
the magnesium levels in these two body fluids on the one hand and febrile convulsions on the other.
From the Department of Pediatrics, M.G.M. Medical College and M.Y. Hospital, Indore. (M.P.) 相似文献
116.
117.
BACKGROUND: Because mitochondria are abundant in white cells and are also present in platelets, polymorphic sequences in mitochondrial DNA (mtDNA) represent a unique target for polymerase chain reaction (PCR)- based detection of donor material. STUDY DESIGN AND METHODS: A PCR assay was developed that uses sequence-specific primers (SSP) focused on two continent-specific mtDNA polymorphisms. Results were validated by the use of informative restriction endonucleases. Three commercially available methods to extract mtDNA from white cell-reduced human platelets was compared. In preparation for in vivo studies, in vitro mixing studies designed to mimic transfusion were conducted to investigate the performance of the SSP-PCR assay. RESULTS: The gene sequences of two representative examples of amplicons obtained with the new SSP-PCR matched the sequence expected from the published genetic code. Fifteen individuals were classified as either positive (n = 6) or negative (n = 9) for the Asian polymorphism by the use of published primers known to flank the polymorphic site followed by digestion with appropriate restriction enzymes. Results with SSP-PCR were nearly perfectly concordant with those of restriction enzyme analysis. Although the use of three DNA extraction methods allowed the preparation of mtDNA that was suitable for PCR, large and consistent differences (ranging from 10- to 1000-fold) in endpoint sensitivity were found. In vitro mixing studies reproducibly documented that the SSP-PCR assay could detect as little as 1 percent of donor platelets mixed with recipient blood. CONCLUSION: PCR-SSP can be reliably used to identify human mtDNA polymorphisms. By optimization of the method of mtDNA extraction, the sensitivity of PCR-SSP assay was greatly increased. This assay should prove useful in investigations of allogeneic platelet transfusions without cell labeling. It may also be applied to studies of the donor cell microchimerism that follows transfusion or transplantation. 相似文献
118.
KM FOCK JY KANG HS NG TM NG KA GWEE CC LIM 《Journal of gastroenterology and hepatology》1995,10(4):379-382
Roxatidine acetate, a new H2 receptor antagonist, was compared with ranitidine in the treatment of duodenal ulcers in a double-blind multicentre study. Eighty-four patients with endoscopically proven duodenal ulcer were randomized to receive 150 mg roxatidine acetate or 300 mg ranitidine at bedtime. Repeat endoscopy was performed after 4 weeks (25–33 days) and if the ulcer had not healed, another endoscopy was performed after a further 4 weeks of treatment. Using per protocol analysis 73.6% of ulcers treated with roxatidine healed at 4 weeks compared to 72.2% of ulcers treated with ranitidine (P=NS). The healing rates at 8 weeks were 92% with roxatidine and 83.3% with ranitidine (P=NS). Using equivalence tests, the healing rate of roxatidine was found to be equivalent to that of ranitidine within a 20% region. Roxatidine users took significantly less antacids than ranitidine users (P < 0.05). There were no significant adverse effects due to roxatidine or ranitidine. Roxatidine is a safe effective drug in the treatment of duodenal ulcers with a healing rate comparable to that of ranitidine. 相似文献
119.
120.