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101.
Yamaguchi Kohei Hara Koji Nakagawa Kazuharu Namiki Chizuru Ariya Chantaramanee Yoshimi Kanako Nakane Ayako Kubota Kazumasa Furuya Junichi Tohara Haruka 《Clinical oral investigations》2020,24(11):3881-3888
Clinical Oral Investigations - This study aimed to investigate the relationship between aging and tooth loss on masseter muscle quantity and quality. This cross-sectional study was conducted among... 相似文献
102.
Kuwada Kohei Kawase Satoshi Nakata Karin Shinya Nodoka Narukawa Yuji Fuchino Hiroyuki Kawahara Nobuo Kiuchi Fumiyuki 《Journal of natural medicines》2020,74(1):135-141
Journal of Natural Medicines - LC–MS analyses of saponin fractions of Achyranthes roots in the Japanese market revealed that there were three patterns for the saponin fraction of their water... 相似文献
103.
Batsukh Zolboo Toume Kazufumi Javzan Batkhuu Kazuma Kohei Cai Shao-Qing Hayashi Shigeki Kawahara Nobuo Maruyama Takuro Komatsu Katsuko 《Journal of natural medicines》2020,74(1):170-188
Journal of Natural Medicines - Saposhnikoviae Radix (SR) is a commonly used crude drug that is obtained from the root and rhizome of Saposhnikovia divaricata which is distributed throughout China,... 相似文献
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Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin
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Ryuzo Kawamori Kohei Kaku Toshiaki Hanafusa Katsuhisa Ioriya Shigeru Kageyama Nigishi Hotta 《Journal of diabetes investigation.》2016,7(2):253-259
Aims/Introduction
The aim of the present study was to evaluate the long‐term efficacy and safety of adding repaglinide in patients with type 2 diabetes mellitus whose blood glucose levels were not sufficiently controlled by treatment with a dipeptidyl peptidase‐4 inhibitor, sitagliptin, in addition to diet and exercise therapies.Materials and Methods
This was a multicenter, uncontrolled, dose‐titration study with a treatment period of 52 weeks. The primary end‐point was the change in glycated hemoglobin levels from baseline.Results
The glycated hemoglobin level was 7.43 ± 0.57% (mean ± standard deviation) at baseline, and decreased to 6.93 ± 0.91% at the end of the study. The mean changes in glycated hemoglobin levels at 4 weeks and at the end of the study were −0.44 ± 0.28% and −0.50 ± 0.82%, respectively. The glycated hemoglobin‐lowering effect was maintained for 52 weeks. The rate of adverse events was 86.0% (86/100), and there were 352 adverse events. The rate of adverse drug reactions was 21.0% (21/100). Hypoglycemia was reported in 5.0% (5/100) of patients, but there was no incidence of ‘major hypoglycemia’.Conclusions
Combination therapy with repaglinide and sitagliptin was considered effective for a long term without clinical safety problems in patients with type 2 diabetes mellitus. 相似文献108.
109.
Takamitsu Hattori Darson Lai Irina S. Dementieva Sherwin P. Monta?o Kohei Kurosawa Yupeng Zheng Louesa R. Akin Kalina M. ?wist-Rosowska Adrian T. Grzybowski Akiko Koide Krzysztof Krajewski Brian D. Strahl Neil L. Kelleher Alexander J. Ruthenburg Shohei Koide 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(8):2092-2097
110.
Hitomi Hosoya Andrey S. Dobroff Wouter H. P. Driessen Vittorio Cristini Lina M. Brinker Fernanda I. Staquicini Marina Cardó-Vila Sara D’Angelo Fortunato Ferrara Bettina Proneth Yu-Shen Lin Darren R. Dunphy Prashant Dogra Marites P. Melancon R. Jason Stafford Kohei Miyazono Juri G. Gelovani Kazunori Kataoka C. Jeffrey Brinker Richard L. Sidman Wadih Arap Renata Pasqualini 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(7):1877-1882
A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.A long-term goal in contemporary cancer nanomedicine has been to design and generate drug delivery systems that improve the narrow therapeutic window associated with conventional chemotherapeutics (1, 2). Conceptually, several nanotechnology-based entity candidates, including protocells (3), biosynthetic nanoparticles (NPs), viruses, and liposome-based nanoparticles, could be targeted for active delivery through a defined cell surface ligand receptor system and/or physically triggered for finely tuned cargo release (2, 4, 5).Numerous efforts have been made to functionalize NPs by combining them with antibodies, aptamers, peptides, vitamins, or carbohydrates (6–8), but the majority of studies involve untargeted nanoplatforms (4, 9). In practice, targeting NPs is far from trivial, and ongoing challenges include synthesis and purification, selection of an appropriate ligand receptor, and specific composition for NP conjugation. Even the conjugation reaction itself may alter the binding of the tumor-targeting moiety to its receptor through conformational changes, steric freedom restriction, or orientation distortion (10, 11). Unfortunately, the cost-to-benefit ratio of these modifications often elevate the complexity of the NP synthesis, complicating regulatory hurdles because of formulations that are heterogeneous or difficult to reproduce (10, 12, 13).To minimize such drawbacks, NPs can be functionalized via virus-based nanoplatforms as an alternative for targeted cargo delivery (14–16). In particular, filamentous bacteriophage (phage)—a prokaryotic virus—is an attractive candidate to develop a bionanomedicine for cancer therapeutics because phage particles are cost-effectively produced with biological uniformity, as well as being physically robust and stable under harsh conditions (17). Notably, phage-based nanoplatforms are biocompatible and nonpathogenic with eukaryotic organisms and are able to preserve the desired cell targeting and internalization (18). Moreover, phage particles are ideal for incorporating other NPs, which can be released after reaching the tumor site. An admixture of colloidal gold NP (AuNP) with phage particles spontaneously organizes into hydrogel network-like fractal structures (19, 20). These hydrogel networks offer convenient multifunctional integration within a single entity for tumor targeting, enhanced fluorescence and dark-field microscopy, near-infrared (NIR) photon-to-heat conversion, and surface-enhanced Raman scattering (SERS)-based detection (20, 21).In the present work, we developed a tumor targeting theranostic (meaning a combination of therapeutics and diagnostics) hydrogel-based nanoplatform that enables ligand-directed tumor targeting, multimodal imaging capability, and triggered therapeutic cargo release. Our data suggest that targeted hydrogel photothermal therapy represents a functional theranostic approach (fostering “see and treat, treat and see”) in the diagnosis and management of tumors. 相似文献