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91.
92.
Management of adrenal metastasis from hepatocellular carcinoma 总被引:9,自引:0,他引:9
Momoi H Shimahara Y Terajima H Iimuro Y Yamamoto N Yamamoto Y Ikai I Yamaoka Y 《Surgery today》2002,32(12):1035-1041
Purpose: Although the adrenal gland is a common site of extrahepatic metastasis from hepatocellular carcinoma (HCC), there are no
definitive guidelines for the treatment of adrenal metastasis. This study examines the effectiveness of various treatments
for this disease.
Methods: We retrospectively analyzed 20 patients treated for adrenal metastasis of HCC by adrenalectomy (n = 13), transarterial chemoembolization (TACE), or percutaneous ethanol injection therapy (PEIT) (n = 7).
Results: There were no significant differences in cumulative survival rates between patients given adrenalectomy and those given TACE
or PEIT, either after completing treatment for primary HCC or after the first treatment for adrenal metastasis. Six of seven
patients with tumor thrombi in the inferior vena cava (IVC) from adrenal metastasis underwent adrenalectomy combined with
intracaval thrombectomy, five of whom survived for more than 1 year after surgery, and two of whom are still alive without
any recurrence more than 3 years after surgery. PEIT showed good results for small adrenal metastasis.
Conclusion: These findings suggest that therapeutic modalities should be chosen according to the clinical features of each individual,
including the size of the metastatic tumor, whether there is invasion into the IVC, the function of the remaining liver, and
the existence of intra- and/or nonadrenal extrahepatic lesions. Furthermore, intracaval tumor thrombectomy could be indicated
for patients with IVC thrombus if they are suitable candidates for surgery.
Received: July 9, 2001 / Accepted: July 2, 2002
Reprint requests to: Y. Shimahara 相似文献
93.
Hayashi K Sato J Fujiwara N Kajita M Fukuharu M Hu X Kuriki K Hoshino H Kato R Tokudome S Sato Y 《Environmental health and preventive medicine》2002,7(3):123-128
Objectives To evaluate the physical strength, cerebral function, and mental health conditions in elderly persons, and to examine the
correlation between these functions.
Methods The subjects were 151 independent-living elderly Japanese women, mean age 70 +/-5 years (+/-SD; range, 60 to 80 years), with
normal abilities in daily life. The health check-up was conducted from April to May 1997. Physical strength was estimated
by measuring seven activities. Cerebral functions were assessed by six sub-tests of the General Aptitude Test Battery (GATB).
Their mental health status was measured by four sub-scales of the General Health Questionnaire (GHQ)-28.
Results The physical strenght and almost all of the cerebral functions decreased with age. Social dysfunction and severe depression
on the GHQ sub-scales also worsened with age. Physical strength was strongly correlated with cerebral functions after adjusting
for the confounding effect of aging. There were also interrelations between physical strength and mental health.
Conclusions This study provided important information on the correlation between physical and mental status in elderly women. Future longitudinal
studies with the intervention of physical training are required to determine whether a causal relationship exists between
these factors. 相似文献
94.
Taste bud cells (TBCs) on soft palates differ from those on tongues in innervation and chemosensitivity. We investigated voltage-gated channels involved in the taste responses of TBCs on mouse soft palates under in-situ tight-seal voltage/current-clamp conditions. Under the cell-attached mode, TBCs spontaneously fired action currents, which were blocked by application of 1 microM TTX to TBC basolateral membranes. Firing frequencies increased in response to taste substances applied to TBC receptor membranes. Under the whole-cell clamp mode, as expected, TBCs produced various voltage-gated currents such as TTX-sensitive Na+ currents (INa), outward currents (Iout) including TEA-sensitive and insensitive currents, inward rectifier K+ currents (Iir), and Ca2+ currents including T-type, P/Q-type, and L-type Ca2+ currents. We classified TBCs into three types based on the magnitude of their voltage-gated Na+ currents and membrane capacitance. HEX type (60% of TBCs examined) was significantly larger in Na+ current magnitude and smaller in membrane capacitance than LEX type (23%). NEX type (17%) had no Na+ currents. HEX type was equally distributed within single taste buds, while LEX type was centrally distributed, and NEX type was peripherally distributed. There were correlations between these electrophysiological cell types and morphological cell types determined by three-dimensional reconstruction. The present results show that soft palate taste buds contain TBCs with different electrophysiological properties, and suggest that their co-operation is required in taste transduction. 相似文献
95.
Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice 总被引:13,自引:0,他引:13
Fujii H Hirose T Oe S Yasuchika K Azuma H Fujikawa T Nagao M Yamaoka Y 《Journal of hepatology》2002,36(5):653-659
BACKGROUND/AIMS: We examined whether bone marrow (BM) cells can commit to liver-consisting cells during liver regeneration after partial hepatectomy, using mice transplanted with green fluorescent protein (GFP) positive BM from GFP transgenic mice. METHODS: Partial hepatectomy or sham operation was performed. Lineage marker analysis of GFP positive liver cells was by immunostaining and flow cytometry. DiI-labeled acetylated low-density lipoprotein uptake or microsphere phagocytosis was examined in vitro. Lineage marker expression in BM and peripheral blood (PB) cells, and the vascular endothelial growth factor (VEGF) concentration in the liver were also examined. RESULTS: In hepatectomized mice, significantly more GFP positive cells participated in liver sinusoid than in sham-operated mice, expressing CD31 but not albumin. The percentage of cells that incorporated acetylated low-density lipoprotein but not microspheres was 69.5+/-3.4%, while 28.3+/-2.6% incorporated both, revealing sinusoidal endothelial and Kupffer cells, respectively. Increased expression of the CD31 and CD16/CD32 on GFP positive liver cells was also detected. The elevation of the VEGF concentration during liver regeneration and the increase in the CD34 and Flk-1 expression in the liver, BM, and PB cells suggested endothelial progenitor cell mobilization. CONCLUSIONS: GFP cell-marking provided direct evidence of the BM cells participation in liver regeneration after hepatectomy, where the majority was committed to sinusoidal endothelial cells probably through endothelial progenitor cell mobilization. 相似文献
96.
Kataoka M Togashi K Koyama T Yamaoka T Iwasa Y Fujii S Konishi J 《Journal of computer assisted tomography》2002,26(4):532-537
This report describes MR findings of müllerian mucinous borderline tumors, pathologically proven to have arisen from endometriotic cysts, in three patients. They were unilocular or paucilocular masses with mural nodules. Cystic components showed hyperintensity on both T1- and T2-weighted images, simulating clear cell or endometrioid carcinomas arising from endometriotic cysts. Mural nodules showed prominent high signal intensity on T2-weighted images. Correlation with pathologic findings suggests that this hyperintensity reflects intraluminal mucinous material and stromal edema. 相似文献
97.
98.
Mammalian circadian pacemaker is located in suprachiasmatic nuclei (SCN) of the hypothalamus. The pacemaker is entrained by light-dark cycle; the photic information is transmitted primarily via the retino-hypothalamic tract (RHT). The main neurotransmitter of the tract is glutamate. RHT fibers end on the ventrolateral part of the nucleus, where vasoactive intestinal peptide (VIP)-immunopositive neurons are localized. They send their axons into dorsomedial SCN, where most of the vasopressinergic (AVP) neurones are located. The AVP neurons retain the clock-like properties in vitro. Vasopressin release from the cultured neurons shows circadian rhythm peaking in the middle of subjective day. VIP induces phase-shifts of the rhythm, magnitude and direction of the shift depending on timing of the application. VIP applied 6-12 h before the peak of vasopressin rhythm induces advances, application 4-8 h after the peak induces delays. The lowest concentration required to induce the phase-shift is 30 nM, further increase of the concentration does not affect the magnitude of the shift. In contrast, glutamate has no effect on the phase of vasopressin rhythm, although in high concentrations it transiently stimulates vasopressin release. The data indicate that the vasopressinergic cells in the SCN contain circadian oscillators, whose rhythms run mutually synchronized in our cultures. VIP acts directly on the vasopressinergic cells to shift the phase of their pacemakers; glutamate has no such effect presumably because in vivo it acts through the VIP-ergic cells but the neuronal network is altered after the dissociation of the cells. 相似文献
99.
Eigo Otsuji Toshiharu Yamaguchi Nobuki Yamaoka Makoto Kato Tatsuya Kotani Kazuya Kitamura Nozomi Yamaguchi Toshio Takahashi 《Cancer science》1993,84(8):914-920
Much recent research has been directed toward the use of monoclonal antibodies (MAb) for the inimunodetection of solid tumors. In pancreatic cancer, the results of conventional immunoscintigraphy using intact MAb remain disappointing. Clear immunoseintigrapliy with radiolabeled MAb requires a high tumor tissue/blood ratio of radioactivity and a low normal tissue/blood ratio of radioactivity. In this study, 125 I-labeled Fab fragments produced by papain digestion of MAb A7 were injected intravenously into nude mice bearing a human pancreatic cancer (HPC-YS) xenograft previously shown to react specifically with MAb A7. The radioactivity of tumors and normal organs was subsequently measured. The tumor tissue/blood ratio of 125 I-labeled Fab fragments of MAb A7 was 1.00±0.24 and 9.68±2.54 at 2 and 24 h after injection, respectively. The tumor tissue/blood ratio of radioactivity was significantly higher than those of normal organs at 24 h after injection. Moreover, the tumor tissue/blood ratio of 125 I-labeled Fab fragments of MAb A7 was greater than that of intact MAb A7, although the 125 I-labeled Fab accumulation level was much less than that of 125 I-labeled intact MAb A7 in the tumor. When mice bearing tumors which did not react with MAb A7 were studied, 125 I-labeled Fab fragments did not specifically localize to the tumors. These results suggest that Fab fragments of MAb A7 may be suitable carriers of radionuclides for the immunodetection of human pancreatic cancer. 相似文献
100.
Novel drug delivery system using autologous fibrin glue--release properties of anti-cancer drugs 总被引:7,自引:0,他引:7
To clarify the release properties of anti-cancer drugs from fibrin glue, a study was performed using several anti-cancer drugs with remarkably different physical properties. Concentrated fibrinogen, fibronectin, and coagulation factor XIII were prepared from healthy human plasma according to the cryoprecipitate method. Fibrin glue containing anti-cancer drugs was prepared as follows; the cryoprecipitate was mixed with each anti-cancer drug and aprotinin, then thrombin was added. These glues were incubated in PBS containing plasminogen and urokinase at 37 degrees C for seven days, and the medium was then sampled several times after centrifugation. The drug concentration in each sample was measured using HPLC. Fibrin glue without aprotinin was quickly hemolyzed and disappeared after 2--4 h. That with aprotinin was only slightly hemolyzed and more than half remained after 7 days. Mitomycin C and fluorouracil were quickly released from the glue regardless of the presence or absence of aprotinin. However, enocitabine was gradually released from glue with aprotinin although quickly released from that without. The rate of release of each drug from the glue with aprotinin correlated well with its hydrophobicity. Thus, to establish a sustained release system using fibrin glue, one should use the more lipophilic anti-cancer drugs and a fibrinolytic enzyme inhibitor. 相似文献