The impact of a brief induction on short-term continuation in a therapeutic community

Continuation in substance abuse treatment is one of the strongest predictors of successful post-treatment outcomes across all major treatment modalities. However, since rates of attrition are highest within the first month of treatment, many clients drop out before these positive outcomes are realized. The impact of organizational and therapeutic factors on treatment continuation in therapeutic communities has received little attention in the literature. This study was conducted to determine whether a brief induction to treatment was associated with improved treatment continuation in a therapeutic community. Multivariable logistic regression analysis indicated that induction was associated with 30-day continuation. Prior treatment and court-mandated treatment were also associated with continuation.     

Changes in nonstructural protein 3 are associated with attenuation in avian coronavirus infectious bronchitis virus

Full-length genome sequencing of pathogenic and attenuated (for chickens) avian coronavirus infectious bronchitis virus (IBV) strains of the same serotype was conducted to identify genetic differences between the pathotypes. Analysis of the consensus full-length genome for three different IBV serotypes (Ark, GA98, and Mass41) showed that passage in embryonated eggs, to attenuate the viruses for chickens, resulted in 34.75-43.66% of all the amino acid changes occurring in nsp 3 within a virus type, whereas changes in the spike glycoprotein, thought to be the most variable protein in IBV, ranged from 5.8 to 13.4% of all changes. The attenuated viruses did not cause any clinical signs of disease and had lower replication rates than the pathogenic viruses of the same serotype in chickens. However, both attenuated and pathogenic viruses of the same serotype replicated similarly in embryonated eggs, suggesting that mutations in nsp 3, which is involved in replication of the virus, might play an important role in the reduced replication observed in chickens leading to the attenuated phenotype.