Niet-reguliere behandelingsmiddelen: de leveranciers en hun produkten

Therapeutic and pharmaceutical aspects of so-called non-regular medical treatment (anthroposophy, homoeopathy, phytotherapy etc.) were investigated by means of an inquiry directed to the suppliers of non-regular drugs. Data of 17 respondents are condensed into two tables and discussed in the light of the Medicines Supply Act. It is concluded that the pharmacist has to inform himself carefully about the non-regular preparations before he decides to supply them to the patient. It is concluded that the Drug Authorities should enforce five requirements regarding these preparations.     

Reduction of contact sensitivity reactions to oxazolone in mite-infested mice.

Oxazolone-sensitized mite-infested (SWR-M) and mite-free (SWR-J) mice were challenged with oxazolone on the skin of the neck and shoulder. The migration of radioactively labeled cells to the site of contact sensitivity reaction to oxazolone was significantly less in SWR-M than in SWR-J mice. Serum obtained from SWR-M mice suppressed the extravasation of cells into the skin site of SWR-J mice challenged with oxazolone. The decrease in cellular influx in SWR-M mice occurred in areas of mite infestation (skin of neck and shoulder) as well as in areas not infested with mites (the ears). SWR-M mice also gave evidence of enhanced vascular permeability. A possible role for histamine in the inhibition of contact sensitivity in mite-infested mice is discussed.     

The development of the circulating blood volume of the chick embryo

Summary The circulating blood volume of the chick embryo was determined from the 4th up to the 18th day of hatching. In contrast to former studies, there was employed a radioisotope dilution method with albumin-bound I¹³¹. The findings are in close correspondence to those of the earlier studies. The blood volume does not display an entirely perfect curve of exponential growth, i.e., the doubling time increases steadily. The blood volume attains a peak value between the 16th and 18th day and decreases somewhat toward the end of the hatching period. There has been postulated a reduction of total red cell volume and hemoglobin caused by the involution of the extraembryonic circulatory system. The destruction of the erythrocytes seems to take place in the endodermal epithelium of the proximal yolk sac, where an accumulation of iron could be demonstrated on the 19th and 20th days.Head of Department: Prof. G. TönduryDissertation under the direction of Prof. J. Rickenbacher.     

Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors

Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. We have used a metabolite profiling approach to test the hypothesis that quantitative signatures of primary metabolites can be used to characterize molecular changes in ovarian tumor tissues. Sixty-six invasive ovarian carcinomas and nine borderline tumors of the ovary were analyzed by gas chromatography/time-of-flight mass spectrometry (GC-TOF MS) using a novel contamination-free injector system. After automated mass spectral deconvolution, 291 metabolites were detected, of which 114 (39.1%) were annotated as known compounds. By t test statistics with P < 0.01, 51 metabolites were significantly different between borderline tumors and carcinomas, with a false discovery rate of 7.8%, estimated with repeated permutation analysis. Principal component analysis (PCA) revealed four principal components that were significantly different between both groups, with the highest significance found for the second component (P = 0.00000009). PCA as well as additional supervised predictive models allowed a separation of 88% of the borderline tumors from the carcinomas. Our study shows for the first time that large-scale metabolic profiling using GC-TOF MS is suitable for analysis of fresh frozen human tumor samples, and that there is a consistent and significant change in primary metabolism of ovarian tumors, which can be detected using multivariate statistical approaches. We conclude that metabolomics is a promising high-throughput, automated approach in addition to functional genomics and proteomics for analyses of molecular changes in malignant tumors.     

Inhibition of IgE production of mice by non-specific suppressor T cells.

SWR adult normal splenic T lymphocytes injected into irradiated syngeneic mice along with immune spleen cells can suppress IgE formation by the immune cells. Spleen cells from 1- or 3-week-old mice, however, are not effective in abrogating IgE synthesis. The T lymphocytes which are induced to become suppressors for IgE are hydrocortisone-resistant and anti-thymocyte serum-sensitive. Normal SJL mice, a poor reagin-producing strain, do not appear to have more suppressor cells or cells which are more easily stimulated to become suppressor cells than a good reagin-producing strain (SWR).     

Psychische Störungen bei Hyperparathyreoidismus

Zusammenfassung Psychopathologische Erscheinungen als Folge eines Hyperparathyreoidismus haben bisher wenig Beachtung gefunden. Auf Grund einer Durchsicht der vorhandenen Literatur sowie der eigenen Erfahrungen an einer in psychiatrischer Hinsicht unausgelesenen Untersuchungsserie scheinen sie eher seltener zu sein, als bei vielen anderen Endokrinopathien. Beobachtet wurden bei einzelnen Kranken leichte emotionelle Verschiebungen und noch häufiger eine Störung einzelner elementarer Triebe, vor allem eine Herabsetzung des Nahrungsbedürfnisses bis zur Anorexie und eine Steigerung des Flüssigkeitsbedürfnisses zum starken Durst. Sie passen in den Rahmen des endokrinen Psychosyndroms M. Bleulers. Verhältnismäßig frühzeitig kann ein amnestisches Psychosyndrom auftreten, nicht selten durch Symptome des akuten exogenen Reaktionstypus nach Bonhoeffer kompliziert. Ein für den Hyperparathyreoidismus typisches psychopathologisches Syndrom läßt sich nicht herausarbeiten. Ein Unterschied zu vielen anderen Endocrinopathien scheint nur darin zu bestehen, daß psychopathologische Veränderungen eher seltener, amnestische Symptome aber eher bevorzugt vorkommen.