全文获取类型
收费全文 | 8228篇 |
免费 | 479篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 123篇 |
儿科学 | 226篇 |
妇产科学 | 237篇 |
基础医学 | 1476篇 |
口腔科学 | 279篇 |
临床医学 | 848篇 |
内科学 | 1392篇 |
皮肤病学 | 215篇 |
神经病学 | 827篇 |
特种医学 | 371篇 |
外科学 | 908篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 529篇 |
眼科学 | 120篇 |
药学 | 541篇 |
中国医学 | 10篇 |
肿瘤学 | 594篇 |
出版年
2023年 | 61篇 |
2022年 | 81篇 |
2021年 | 172篇 |
2020年 | 129篇 |
2019年 | 136篇 |
2018年 | 166篇 |
2017年 | 137篇 |
2016年 | 201篇 |
2015年 | 196篇 |
2014年 | 263篇 |
2013年 | 360篇 |
2012年 | 532篇 |
2011年 | 564篇 |
2010年 | 354篇 |
2009年 | 344篇 |
2008年 | 496篇 |
2007年 | 509篇 |
2006年 | 432篇 |
2005年 | 453篇 |
2004年 | 439篇 |
2003年 | 420篇 |
2002年 | 392篇 |
2001年 | 135篇 |
2000年 | 104篇 |
1999年 | 139篇 |
1998年 | 107篇 |
1997年 | 77篇 |
1996年 | 52篇 |
1995年 | 67篇 |
1994年 | 50篇 |
1993年 | 47篇 |
1992年 | 99篇 |
1991年 | 55篇 |
1990年 | 67篇 |
1989年 | 61篇 |
1988年 | 39篇 |
1987年 | 43篇 |
1986年 | 44篇 |
1985年 | 54篇 |
1984年 | 41篇 |
1983年 | 26篇 |
1982年 | 40篇 |
1981年 | 22篇 |
1978年 | 34篇 |
1977年 | 27篇 |
1976年 | 28篇 |
1974年 | 25篇 |
1973年 | 21篇 |
1972年 | 32篇 |
1971年 | 29篇 |
排序方式: 共有8734条查询结果,搜索用时 9 毫秒
81.
Kerstin Kempf Martin Rhling Winfried Banzer Klaus Michael Braumann Martin Halle David McCarthy Hans Georg Predel Isabelle Schenkenberger Susanne Tan Hermann Toplak Aloys Berg Stephan Martin 《Nutrients》2021,13(5)
Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the international multicentre randomised controlled ACOORH (Almased Concept against Overweight and Obesity and Related Health Risk) trial, overweight or obese persons who meet the criteria for metabolic syndrome (n = 463) were randomised into two groups. Both groups received nutritional advice focusing on carbohydrate restriction and the use of telemonitoring devices. The intervention group substituted all three main meals per day in week 1, two meals per day in weeks 2–4, and one meal per day in weeks 5–26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline and after 1, 3, 6 and 12 months. All datasets providing insulin data (n = 446) were included in this predefined subanalysis. Significantly higher reductions in insulin (−3.3 ± 8.7 µU/mL vs. −1.6 ± 9.8 µU/mL), weight (−6.1 ± 5.2 kg vs. −3.2 ± 4.6 kg), and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and the highest amount of weight loss (−7.6 ± 4.9 kg) was observed in those participants with an insulin decrease > 2 µU/mL. These results underline the potential for meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin levels may serve as an indicator for adherence to carbohydrate restriction. 相似文献
82.
Ezgi Dogan-Sander Roland Mergl Anja Willenberg Ronny Baber Kerstin Wirkner Steffi G. Riedel-Heller Susanne Rhr Frank M. Schmidt Georg Schomerus Christian Sander 《Nutrients》2021,13(6)
Depression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (IL-6 and CRP levels, WBC count) were quantified. Mediation analyses were performed using Hayes’ PROCESS macro and regression analyses were conducted to test moderation effects. There was a significant negative correlation between CES-D and 25(OH)D, and positive associations between inflammatory markers and CES-D scores. Only WBC partially mediated the association between 25(OH)D levels and depressive symptoms both in a simple mediation model (ab: −0.0042) and a model including covariates (ab: −0.0011). None of the inflammatory markers showed a moderation effect on the association between 25(OH)D levels and depressive symptoms. This present work highlighted the complex relationship between vitamin D, depressive symptoms and inflammation. Future studies are needed to examine the effect of vitamin D supplementation on inflammation and depressive symptomatology for causality assessment. 相似文献
83.
Bußkamp Annalena Vonstein Claudia Tillmann Judith Roßmann Christin De Bock Freia 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(5):560-567
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Wissenschaftliche Ergebnisse können eine Wissensquelle für kommunale Akteurinnen und Akteure der... 相似文献
84.
Rossmann Christin Bußkamp Annalena De Bock Freia 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(5):544-551
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Kommunale AkteurInnen erfahren bei der Entwicklung und Auswahl von Maßnahmen der Prävention und... 相似文献
85.
Spura Anke Reibling Nadine Thaiss Heidrun M. De Bock Freia 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(12):1481-1482
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - 相似文献
86.
Lorenz Ulrich Anna Michelitsch Nico Halwe Kerstin Wernike Donata Hoffmann Martin Beer 《Emerging infectious diseases》2021,27(4):1193
After experimental inoculation, severe acute respiratory syndrome coronavirus 2 infection was confirmed in bank voles by seroconversion within 8 days and detection of viral RNA in nasal tissue for up to 21 days. However, transmission to contact animals was not detected. Thus, bank voles are unlikely to establish effective transmission cycles in nature. 相似文献
87.
88.
Arturo Blazquez-Navarro Chantip Dang-Heine Patrizia Wehler Toralf Roch Chris Bauer Sindy Neumann Rodrigo Blazquez-Navarro Andriy Kurchenko Kerstin Wolk Robert Sabat Timm H. Westhoff Sven Olek Oliver Thomusch Harald Seitz Petra Reinke Christian Hugo Birgit Sawitzki Michal Or-Guil Nina Babel 《Transplant international》2021,34(9):1680-1688
Epstein–Barr virus (EBV) reactivation is a very common and potentially lethal complication of renal transplantation. However, its risk factors and effects on transplant outcome are not well known. Here, we have analysed a large, multi-centre cohort (N = 512) in which 18.4% of the patients experienced EBV reactivation during the first post-transplant year. The patients were characterized pre-transplant and two weeks post-transplant by a multi-level biomarker panel. EBV reactivation was episodic for most patients, only 12 patients showed prolonged viraemia for over four months. Pre-transplant EBV shedding and male sex were associated with significantly increased incidence of post-transplant EBV reactivation. Importantly, we also identified a significant association of post-transplant EBV with acute rejection and with decreased haemoglobin levels. No further severe complications associated with EBV, either episodic or chronic, could be detected. Our data suggest that despite relatively frequent EBV reactivation, it had no association with serious complications during the first post-transplantation year. EBV shedding prior to transplantation could be employed as biomarkers for personalized immunosuppressive therapy. In summary, our results support the employed immunosuppressive regimes as relatively safe with regard to EBV. However, long-term studies are paramount to support these conclusions. 相似文献
89.
90.
Rachel Wuerstlein Nadia Harbeck Eva-Maria Grischke Dirk Forstmeyer Raquel von Schumann Petra Krabisch Kerstin Lüdtke-Heckenkamp Andrea Stefek Oliver Stoetzer Andrea Grafe Gabriele Kaltenecker Helmut Forstbauer Doris Augustin Iris Schrader Joke Tio Ulrike Nitz Oleg Gluz Ronald E. Kates Monika Karla Graeser 《Breast care (Basel, Switzerland)》2021,16(1):50
BackgroundProtroca evaluated the efficacy and safety of primary and secondary prophylaxis of neutropenia with lipegfilgrastim (Lonquex®) in breast cancer patients receiving neoadjuvant or adjuvant chemotherapy (CT).Patients and MethodsOf the 255 patients enrolled, 248 patients were evaluable for the intent-to-treat (ITT) and 194 patients for the per-protocol set. Primary and secondary end points after lipegfilgrastim treatment were assessed.ResultsNine patients of the ITT set receiving lipegfilgrastim as primary prophylaxis (n = 222) had febrile neutropenia of grade 3–4 (5 patients) or infection of grade 3–4 (4 patients); 1/26 of those receiving secondary prophylaxis had an event. Dose reductions were performed in 9.5% of the patients. Postponement of cancer CT cycles for >3 days occurred in <15% of patients; 10.8% (92/851 AEs) and 8% (2/25 SAEs) of documented adverse events and serious adverse events, respectively, were related to lipegfilgrastim.ConclusionsApplication of lipegfilgrastim was effective as primary and secondary prophylaxis in the prevention of CT-induced neutropenia in breast cancer. 相似文献