全文获取类型
收费全文 | 855篇 |
免费 | 43篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 35篇 |
妇产科学 | 21篇 |
基础医学 | 137篇 |
口腔科学 | 11篇 |
临床医学 | 57篇 |
内科学 | 159篇 |
皮肤病学 | 15篇 |
神经病学 | 61篇 |
特种医学 | 27篇 |
外科学 | 54篇 |
综合类 | 20篇 |
预防医学 | 89篇 |
眼科学 | 87篇 |
药学 | 72篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 5篇 |
2022年 | 12篇 |
2021年 | 29篇 |
2020年 | 16篇 |
2019年 | 23篇 |
2018年 | 23篇 |
2017年 | 24篇 |
2016年 | 17篇 |
2015年 | 32篇 |
2014年 | 34篇 |
2013年 | 59篇 |
2012年 | 65篇 |
2011年 | 99篇 |
2010年 | 42篇 |
2009年 | 36篇 |
2008年 | 59篇 |
2007年 | 62篇 |
2006年 | 58篇 |
2005年 | 50篇 |
2004年 | 46篇 |
2003年 | 33篇 |
2002年 | 27篇 |
2001年 | 9篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有900条查询结果,搜索用时 62 毫秒
41.
Parag K. Shah V. Narendran N. Kalpana Clare Gilbert 《Indian journal of pediatrics》2009,76(8):801-804
Objective
To describe the characteristics of babies with severe retinopathy of prematurity (ROP) attending a tertiary referral eye hospital in South India. 相似文献42.
Subrata Mallick Satyanarayan Pattnaik Kalpana Swain Pintu K De Arindam Saha Gaurisankar Ghoshal Arijit Mondal 《European journal of pharmaceutics and biopharmaceutics》2008,68(2):346-351
Ibuprofen was milled in the solid state with kaolin (hydrated aluminium silicate) in different ratio to examine the extent of transformation from crystalline to amorphous state. The physical stability of the resultant drug was also investigated. X-ray powder diffractometry (XRD) and birefringence by Scanning Electron Microscopy (SEM) studies indicated almost complete amorphization of the drug on ball milling with kaolin at 1:2 ratio. Fourier transform infrared spectroscopy (FTIR) data showed a reduction in the absorbance of the free and the hydrogen-bonded acid carbonyl peak of carboxylic acid group accompanied by a corresponding increase in the absorbance of the carboxylate peak, indicating an acid-base reaction between the carboxylic acid containing ibuprofen and kaolin on milling. The extent of amorphization and reduction in the carbonyl peak and increase in carboxylate peak was a function of kaolin concentration in the milled powder. On storage of milled powder (at 40 degrees C and 75% RH for 10 weeks), XRD and birefringence of SEM study showed the absence of reversion to the crystalline state and FTIR data revealed continued reduction of carbonyl peak, whereas, ibuprofen converted from its crystalline acid form to amorphous salt form on milling with kaolin. Kaolin-bound state of ibuprofen was physically stable during storage. In-vitro dissolution studies revealed that percent release of ibuprofen from the kaolin co-milled powder is in the order: 1:2>1:1>1:0.5>1:0.1>milled alone ibuprofen>crystalline ibuprofen. 相似文献
43.
Influence of Systemic Chemotherapy on Anti-P-glycoprotein Antibody-dependent Cell-mediated Cytotoxicity in Patients with Small Cell Lung Cancer 总被引:3,自引:0,他引:3
Nabioullin Roustem; Yanagawa Hiroaki; Haku Takashi; Hiramatsu Keiji; Yano Seiji; Hanibuchi Masaki; Pai Kalpana; Tsuruo Takashi; Sone Saburo 《Japanese journal of clinical oncology》1995,25(4):124-130
Anti-P-glycoprotein antibody (MRK-16)-dependent cell-mediatedcytotoxicity (ADCC by blood mononuclear cells (MNC was examinedin patients with small cell lung cancer (SCLC) before and aftersystemic chemotherapy. The effect of in vitro treatment of MNCwith interleukin (IL)-2 and macrophage-colony-stimulating factor(M-CSF) was also examined. The ADCC reaction was assessed bya 6 h 51 Cr-release assay using a multidrug-resistant (MDR)SCLC cell line (H69/VP cells). The MRK-16 monoclonal antibodywas able to augment spontaneous cytotoxicity by MNC, even inSCLC patients. Pretreatment of MNC with IL-2 significantly augmentedtheir ADCC ability in SCLC patients, while M-CSF had no effecton ADCC activity. After the first cycle of systemic chemotherapy,the ADCC activity tended to decline, but ADCC of MNC pretreatedwith IL-2 was not affected. The results suggest that anti-P-glycoproteinantibody, in combination with a cytokine such as IL-2, may betherapeutically useful against human SCLC resistant to chemotherapeuticdrugs. 相似文献
44.
Hyperhomocysteinemia,and low intakes of folic acid and vitamin B12 in urban North India 总被引:2,自引:0,他引:2
Misra A Vikram NK Pandey RM Dwivedi M Ahmad FU Luthra K Jain K Khanna N Devi JR Sharma R Guleria R 《European journal of nutrition》2002,41(2):68-77
Summary
Background and Aim An adverse coronary risk profile has been reported amongst rural-to-urban migrant population living in urban slums undergoing
stressful socio-economic transition. These individuals are likely to have low intakes of folic acid and vitamin B12, which
may have an adverse impact on serum levels of homocysteine (Hcy). To test this hypothesis, we studied serum levels of Hcy
in subjects living in an urban slum of North India and healthy subjects from urban non-slum area. Methods Group I consisted of 46 subjects (22 males and 24 females) living in an urban slum, while group II consisted of healthy subjects
(n = 26, 13 males and 13 females) living in the adjacent non-slum area. Anthropometric measurements, biochemical profile (fasting
blood glucose, total cholesterol, serum triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol)
and fasting serum levels of Hcy were measured. Dietary intakes of folic acid, vitamin B12, vitamin B1, and iron were calculated
by the 24-hour dietary recall method. Serum levels of Hcy were correlated with dietary intakes of nutrients, anthropometry,
and metabolic variables. Results Sex-adjusted serum levels of Hcy in mmol/L (Mean ± SD) were high, though statistically comparable, in both the groups (group
I: 20.8 ± 5.9 and group II: 23.2 ± 5.9). Overall, higher than normal serum levels of Hcy (> 15 μmol/L) were recorded in 84
% of the subjects. A substantial proportion of subjects in both groups had daily nutrient intakes below that recommended for
the Asian Indian population (folic acid: 93.4 % in group I and 96.7 % in group II, vitamin B12: 76.1 % in group I and 88.4
% in group II). However, between the two groups, average daily dietary intakes of both the nutrients were statistically comparable.
As compared to non-vegetarians, vegetarians showed lower intakes of folic acid (p < 0.01) and vitamin B12 (p < 0.01) in both
groups. On multivariate linear regression analysis with serum Hcy as the response variable and vegetarian/non-vegetarian status
and sex (male/female) as predictor variables, higher serum levels of Hcy were observed in vegetarians vs non-vegetarians (β
= 4.6, p < 0.05) and males vs females (β = 5.3, p < 0.01). Conclusions Low intakes of folic acid and vitamin B12, and hyperhomocysteinemia, in both the healthy population living in urban slums
and adjacent urban non-slum areas, are important observations for the prevention of nutritional and cardiovascular diseases
in the Indian subcontinent.
Received: 30 October 2001, Accepted: 14 January 2002 相似文献
45.
A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India
Bellinger DC Hu H Kalaniti K Thomas N Rajan P Sambandam S Ramaswamy P Balakrishnan K 《International journal of occupational and environmental health》2005,11(2):138-143
The relationship between blood lead level and neurodevelopment was assessed in a pilot cross-sectional study of 74 4-14-year-old children in Chennai, India. Mean blood lead level was 11.1 microg/dL (2.5-38.3). The Binet-Kamath IQ test and the Wide Range Assessment of Visual Motor Activity (WRAVMA) were administered to 58 children. Teachers completed the Connor's Behavioral Rating Scale. Excluding two outliers, IQ and WRAVMA composite scores were inversely related to blood lead level, with an effect size of approximately 6 points decline for a 10-microg/dL increase in blood lead. Children in the highest and lowest blood lead quartiles had mean IQs of 95.6+/-13.3 and 102.0+/-22.5, respectively. Behavior ratings were not associated with blood lead level. Lead exposure is a significant problem among Indian children, with many having blood lead levels associated with increased neurodevelopmental risk. 相似文献
46.
Gosavi A Kulkarni M Sulhyan K Agashe S 《Indian journal of pathology & microbiology》2005,48(2):208-210
A case of intrathyroid parathyroid adenoma which clinically and cytologically mimicked thyroid tumor is presented. The patient was normocalcemic inspite of clinical and radiological features suggestive of hyperparathyroid bone disease. The adenoma showed an area of infarction presumably accounting for the normocalcemic primary hyperparathyroidism. The case is reported for its unusual presentation. 相似文献
47.
Lanz TA Fici GJ Merchant KM 《The Journal of pharmacology and experimental therapeutics》2005,312(1):399-406
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile. The objective of the present studies was to compare the efficacy of a subset of NSAIDs with previously reported classical gamma-secretase inhibitors LY-411575 [N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]and DAPT [N-[N- (3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester] in Tg2576 mice. Flurbiprofen (10 and 25 mg/kg/day) was overtly toxic and elicited significant (but nonselective) reductions in both Abeta(1-40) and Abeta(1-42) in the plasma in one of two studies. Flurbiprofen also produced a small reduction in Abeta(1-40) in the cortex at 25 mg/kg/day but did not affect Abeta levels in hippocampus or cerebrospinal fluid. Ibuprofen and sulindac sulfide were neither overtly toxic nor efficacious at doses up to 50 mg/kg/day. The effects of NSAIDs LY-411575 and DAPT were tested in guinea pig embryonic neuronal cultures to determine whether the selective reductions in Abeta(1-42) observed in cell lines overexpressing human mutant APP can be reproduced in a neuronal model of physiological Abeta production and secretion. Flurbiprofen and sulindac nonselectively reduced Abeta(1-40) and Abeta(1-42) at concentrations > or =125 microM, although cytotoxicity was noted at > or =250 microM sulindac. Ibuprofen had no effect at concentrations up to 500 microM. In contrast, DAPT and LY-411575 potently and completely inhibited Abeta(1-40), Abeta(1-42), and Abeta(1-38) in the absence of cytotoxicity. The divergence of the present data from published reports raises the need to examine the conditions necessary to perceive selective Abeta(1-42) reduction by NSAIDs in neuronal tissue. 相似文献
48.
OBJECTIVES: Minority women are less likely to use hormone replacement therapy (HRT), and the health characteristics associated with HRT use in this population are not well studied. We sought to examine the sociodemographic characteristics, health and preventive practices associated with HRT use among minority women. DESIGN: Survey SETTING: Inpatient and outpatient units of a teaching hospital. PARTICIPANTS: A convenience sample of 333 minority women aged 50 and above. VARIABLES: HRT use, demographic and lifestyle characteristics, and selected preventive practices. RESULTS: 14% of the study population, all minority women were using HRT. Regular exercise (p=0.03), and good perceived health status (p=0.02) were significant predictors of HRT use. None of the cancer screening measures studied were associated with HRT use. CONCLUSIONS: Only a small proportion of minority women were using HRT. Regular exercise and perceived good health were significant predictors of HRT use. 相似文献
49.
Pigmentary demarcation lines in pregnancy 总被引:2,自引:0,他引:2
50.
Fibrodysplasia ossificans progressiva 总被引:1,自引:0,他引:1
Subramanyam L Gowrishankar K Shivbalan S Balachandran A 《Indian journal of pediatrics》2004,71(6):563-564
A 2-year-old boy presented with low-grade fever and multiple progressive painful swellings over upper dorsal trunk and supraclavicular
region with progressive stiffening of skin for the last 2 months. Examination revealed dysmorphic face, proximally placed
thumb and bilateral hallux valgus. Hence, a diagnosis of Fibrodysplasia Ossificans Progressiva was entertained 相似文献