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91.
1. Boyden chambers were used to investigate the effects of indomethacin on fibroblast chemotaxis to a conditioned medium. 2. It was determined that indomethacin did not inhibit, but enhanced fibroblast chemotaxis at a concentration of 10(-4) (91%)-10(-6) M (79%). 3. No significant difference was found between controls and cells treated with 10(-8)-10(-10) M indomethacin. 相似文献
92.
93.
Scalp cooling in the prevention of alopecia in patients receiving depilating chemotherapy 总被引:2,自引:0,他引:2
I. G. Ron M.D. Y. Kalmus B.A. Z. Kalmus R.N. M. Inbar M.D. S. Chaitchik M.D. 《Supportive care in cancer》1997,5(2):136-138
To assess any difference in the incidence of alopecia during treatment and of skull metastases during follow-up among breast cancer patients undergoing scalp cooling during chemotherapy and those treated at ambient temperatures. A series of 35 breast cancer patients receiving adjuvant chemotherapy were consecutively assigned either to a scalp cooling regimen (19 patients) or to an ambient temperature regimen (16 patients). Hypothermia was administered with electrically cooled caps (SCS 11: Amit Technology, Jerusalem) for 30 min before, during, and for 1 h after treatment. A significant difference (P=0.014) was detected in the incidence of alopoecia: 48% (9 patients) of those who had undergone cooling suffered alopoecia, while 81% (13 patients) of the group who had not undergone cooling lost scalp hair. Patient comfort levels were high. Follow-up (median time 14 months) has disclosed no scalp metastases. The implementation of routine scalp hypothermia as part of adjuvant chemotherapy treatment, especially in cancers without tendencies to bone metastases, should be seriously considered. 相似文献
94.
The effects of the vasodilator hydralazine (HYD) on microcirculatory function and hyperthermic response were studied in early generation isotransplants of a spontaneous C3Hf/Sed mouse fibrosarcoma (FSall). Red blood cell flux (RBC flux) in superficial tumor regions was assessed using laser Doppler flowmetry. A differential microcirculatory response was seen between tumor and normal skin after 0.25 micrograms/g i.p. HYD, the tumor showing a transient increase in flow and the skin remaining almost stable. At 1.0 micrograms/g i.p., the differential response continued, this time with a transient fall in tumor blood flow but again no change in skin flow. High dose hydralazine (10.0 micrograms/g i.p.) was associated with a dramatic and prolonged decrease in tumor blood flow but a lesser and only transient decline in skin flow. Identical doses of hydralazine were given 30 min prior to heat treatment (43.5 degrees C for 15, 30, or 60 min). Tumor growth was measured daily and compared to controls (HT without hydralazine). Hydralazine at 0.25 micrograms/g i.p. did not affect heat induced growth delay. At 1.0 micrograms/g i.p., it significantly increased growth delay upon heat exposures of 15 min, but not after 30 or 60 min HT. Hydralazine at 10 micrograms/g i.p. increased growth delay for all heat doses (P less than 0.05). Hydralazine alone had no influence on growth delay of sham-heated tumors. The results obtained clearly indicate that tumor and normal tissues have microcirculatory differences in the time-course, degree and/or direction of response after hydralazine, and that hydralazine has potential for increasing the response of tumor to HT. 相似文献
95.
John W. Boyd BS Gerhard W. Kalmus PhD Sam N. Pennington PhD 《Alcoholism, clinical and experimental research》1984,8(4):343-346
Retarded fetal brain growth is associated with a high incidence of mental retardation among the offspring of chronic alcoholic mothers. Research using an embryonic chick model suggests that ethanol exposure suppresses fetal development including suppression of brain growth. Total brain cyclic AMP content and endogenous brain protein kinase specific activity are not altered by ethanol; however, ethanol exposure does significantly stimulate kinase catalytic activity measured in the presence of saturating amounts of exogenous cyclic AMP. 相似文献
96.
Romanese Elbel Schrader Einar Sjövall Breitenecker Wilcke B. Mueller K. Rintelen v. Neureiter Bergemann O. Schmidt Gerstel Kalmus Franz G. Beyer Zieglwallner Weimann v. Marenholtz Frhr. v. Marenholtz Portius Mayser Gebele Cristofoletti Alfred Saal 《International journal of legal medicine》1938,29(5):426-430
Ohne Zusammenfassung 相似文献
97.
Brieger Ziemke Kalmus Karl M. Walthard Hans Strauss Helmut Scharfetter F. Stern Maas Liguori-Hohenauer Jahnel Neustadt Imber S. Kalischer Henneberg Jendralski Kurt Mendel Fr. Wohlwill Pinéas Ziemke Josef Wilder Heinz Lossen E. Glass Joseph A. Meyer H. Merkel Matwejeff 《International journal of legal medicine》1931,17(4-5):216-229
Ohne Zusammenfassung 相似文献
98.
A. Lorenz Timm Keim Schwarzacher F. Fränkel W. Misch H. Merkel Weimann Bettzieche G. Strassmann O. Schmidt S. Talwik Jochims Junius Behrens Wietrich Ziemke Vorkastner Josef Wilder Lahm Prinzing J. Vas Teleky Rasor Kalmus Schönberg O. Seifert Wilcke Ganter Marx Kalmus v. Neureiter H. Scholz Albert Meyerstein R. Schoen Jastrowitz Kastan Foerster Albrecht P. F. Richter Pieper 《International journal of legal medicine》1930,14(3):103-116
99.
100.
Kalmus Reuter K. Raecke Leibbrand Tbben Roemer Hans Prinzing Flade Ganter Strassmann G. Loewenstein Georg Autoreferat 《International journal of legal medicine》1928,12(6):121-125
International Journal of Legal Medicine - 相似文献