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排序方式: 共有220条查询结果,搜索用时 31 毫秒
201.
Imaging of tumoral calcinosis: new observations 总被引:7,自引:0,他引:7
Five patients with tumoral calcinosis were evaluated with radiography, bone scintigraphy, computed tomography (CT), and magnetic resonance (MR) imaging. The arthropathy of calcium pyrophosphate dihydrate deposition disease was seen in two of the patients and pseudoxanthoma elasticum-like syndrome in three. Identification of calcific particular masses on radiographs is characteristic of tumoral calcinosis. Marrow lesions could be identified as patchy areas of calcification (calcific myelitis) in long bones and the calvarium. Bone scintigraphy appears to be the best modality for detection of the masses and marrow lesions and for monitoring therapy. At CT the masses demonstrated a varied appearance, from small and solid to large and cystic. The marrow abnormality appears as an area of increased attenuation and spotty calcification that in the skull may be associated with dural and vascular calcifications. MR imaging of the particular masses was remarkable in that the masses displayed high signal intensity on T2-weighted images despite a large calcific component. Marrow lesions also showed increased signal intensity on T2-weighted images. When calcified particular masses are present the diagnosis is rarely in question. The diagnosis may be overlooked, however, when calcific myelitis is the only manifestation. 相似文献
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A human gonadotrophin releasing hormone (GnRH) upstream promoter/luciferase
reporter gene construct (H2 construct) was generated by inserting a 1.7 kb
XbaI/AflII fragment containing the human GnRH upstream promoter region only
into a promoter-less luciferase reporter vector. When JEG-3 cells were
transiently transfected with this construct and treated with cortisol or
its synthetic analogue dexamethasone, a stimulatory effect on the upstream
promoter activity was observed. This stimulation was dependent on the
cotransfection of a glucocorticoid receptor (GR) cDNA expression vector due
to the low level of GR in JEG-3 cells and could be completely abolished by
RU486, a glucocorticoid antagonist. Moreover, the cortisol actions could be
modulated to a different extent by oestradiol. Thus, since the human
placenta contains GRs and the increase in cortisol metabolism near term is
regulated by oestrogen, the current findings suggest that cortisol may be
physiologically involved in the regulation of GnRH gene expression in the
human placenta.
相似文献
204.
P Christiansen J Müller S Buhl OR Hansen N Hobolth BB Jacobsen PH Jørgensen KW Kastrup K Nielsen LB Nielsen L Pedersen-Bjergaard KE Petersen SA Petersen E Thamdrup E Thisted L Tranebjærg NE Skakkebæk 《Acta paediatrica (Oslo, Norway : 1992)》1992,81(8):605-608
In a modified, double-blind controlled study, 163 prepubertal boys (aged 1.8-13.0 years) with bilateral and 94 (aged 1.5-13.1 years) with unilateral cryptorchidism were allocated to treatment with either human chorionic gonadotrophin (im), gonadotrophin releasing hormone (intranasally) or placebo (intranasally). In individuals with the bilateral condition treatment with human chorionic gonadotrophin resulted in complete descent of both testes in 23% of patients. Treatment with human chorionic gonadotrophin in unilateral cryptorchidism resulted in complete descent in 19% of patients; all results were significantly better than those obtained with gonadotrophin releasing hormone or placebo. Linear and logistic regression analysis of the results obtained by treatment of bilateral disease showed that all treatments were more successful the younger the age of the boys. The data indicated that bilateral and unilateral cryptorchidism respond differently to hormonal treatment. We suggest that human chorionic gonadotrophin should be the first choice of treatment for prepubertal boys older than one year. 相似文献
205.
Winnie KW So PhD RN Gigi CC Ling MN RN Kai‐chow Choi PhD Carman WH Chan PhD RN Rayman WM Wan MN RN Suzanne SS Mak MN RN Janet WH Sit PhD RN 《International journal of nursing practice》2013,19(3):306-317
The purpose of this study is to compare health‐related quality of life (HRQoL) and emotional distress among diverse cancer survivors who had completed all treatment within the previous year. A convenience sample of 353 cancers survivors (lung, head and neck, breast and prostate cancers) were recruited to complete a survey, which consisted of (i) Hospital Anxiety and Depression Scales; (ii) Chinese version of the Functional Assessment of Cancer Therapy—General version; and (iii) demographic and clinical data. The HRQoL scores were similar among the four types of survivors. Mild anxiety and depression levels were reported, but no significant difference was noted. Younger females with financial burdens and uncertain prognosis were particularly associated with HRQoL and emotional distress. Further studies are essential to identify specific problems that cancer patients experience after cancer diagnosis that might lead to the early detection of those most at risk of ongoing problems. 相似文献
206.
William Z Morris Raymond W Liu Elena Chen Harry KW Kim 《Journal of orthopaedic research》2019,37(8):1784-1789
Legg–Calve–Perthes disease is characterized by the capital femoral epiphyseal collapse, which occurs more reliably in the anterior quadrant than the more weight‐bearing lateral quadrant. The purpose of this study was to determine whether there is a vascular or microstructural predisposition for anterior femoral epiphyseal collapse in Perthes disease. Thirty‐two cadaveric proximal femoral epiphyses from 17 subjects (age 4–14 years old) underwent micro‐computed tomography at 10‐μm resolution. Each quadrant was analyzed for four markers of trabecular architecture: bone volume fraction (BV/TV), trabecular thickness, trabecular separation (TbSp), and trabecular number (TbN). Vascular channels were then mapped in each quadrant, identified by correlating surface topography with cross‐sectional imaging. One‐way analysis of variance revealed an overall difference between quadrants (p < 0.001) in BV/TV, TbN, and TbSp. However, post hoc analysis revealed there was no significant difference between the anterior and lateral quadrants for any of the four markers of trabecular architecture. Vascular channel mapping illustrated a predominance of vessels in the posterior half of the epiphysis compared to the anterior half (8.7 ± 4.0 vs. 3.4 ± 3.1 vascular channels, p < 0.001). The lack of microstructural differences between the anterior and lateral quadrants, and the predominance of vascular channels in the posterior half of the epiphysis with posteriorly‐based medial femoral circumflex and ligamentum teres vessels suggests that the anterior femoral epiphysis may be a relative vascular watershed region, which predisposes it to collapse after the vascular insult of Perthes disease. Clinical significance: Improved understanding of the pathophysiology of anterior femoral epiphyseal collapse may inform future treatments aimed at revascularization. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1784–1789, 2019 相似文献
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The catechol‐O‐methyltransferase (COMT) Val158Met genotype modulates working memory‐related dorsolateral prefrontal response and performance in bipolar disorder
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