全文获取类型
收费全文 | 1771133篇 |
免费 | 126822篇 |
国内免费 | 10910篇 |
专业分类
耳鼻咽喉 | 23748篇 |
儿科学 | 55017篇 |
妇产科学 | 44639篇 |
基础医学 | 260061篇 |
口腔科学 | 48523篇 |
临床医学 | 164339篇 |
内科学 | 327049篇 |
皮肤病学 | 38918篇 |
神经病学 | 128002篇 |
特种医学 | 67884篇 |
外国民族医学 | 341篇 |
外科学 | 259465篇 |
综合类 | 57028篇 |
现状与发展 | 32篇 |
一般理论 | 415篇 |
预防医学 | 127248篇 |
眼科学 | 41571篇 |
药学 | 144074篇 |
130篇 | |
中国医学 | 12461篇 |
肿瘤学 | 107920篇 |
出版年
2021年 | 19065篇 |
2019年 | 16748篇 |
2018年 | 22271篇 |
2017年 | 18124篇 |
2016年 | 19531篇 |
2015年 | 23338篇 |
2014年 | 31061篇 |
2013年 | 42141篇 |
2012年 | 57443篇 |
2011年 | 60719篇 |
2010年 | 36969篇 |
2009年 | 33716篇 |
2008年 | 53495篇 |
2007年 | 56860篇 |
2006年 | 57037篇 |
2005年 | 53649篇 |
2004年 | 50604篇 |
2003年 | 48611篇 |
2002年 | 46499篇 |
2001年 | 89420篇 |
2000年 | 90855篇 |
1999年 | 75713篇 |
1998年 | 20266篇 |
1997年 | 17935篇 |
1996年 | 17623篇 |
1995年 | 16698篇 |
1994年 | 15152篇 |
1993年 | 13996篇 |
1992年 | 56066篇 |
1991年 | 54715篇 |
1990年 | 53597篇 |
1989年 | 51944篇 |
1988年 | 46998篇 |
1987年 | 45673篇 |
1986年 | 43227篇 |
1985年 | 40510篇 |
1984年 | 29613篇 |
1983年 | 25047篇 |
1982年 | 13921篇 |
1979年 | 26688篇 |
1978年 | 18343篇 |
1977年 | 16072篇 |
1976年 | 14504篇 |
1975年 | 16361篇 |
1974年 | 19071篇 |
1973年 | 18360篇 |
1972年 | 17439篇 |
1971年 | 16351篇 |
1970年 | 15301篇 |
1969年 | 14500篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Ludefu Su Yu Liu Yanhong Tang Mingmin Zhou Liang Xiong Congxin Huang 《International journal of clinical and experimental pathology》2021,14(4):408
Background and objective: Myocardial infarction (MI) is a common critical disease of the cardiovascular system. The process of MI is often accompanied by the excessive activation of cardiac sympathetic nerves, which leads to arrhythmia. Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. However, whether RTX can reduce the occurrence of arrhythmia and exert a cardioprotective effect by inhibiting the sympathetic reflex during MI is still unknown. Methods: The left anterior descending artery of cardiac was clamped to construct a model of MI. RTX (50 μg/ml) was used by epicardial application in MI rats. Ventricular electrophysiologic properties were continuously monitored by a body surface ECG. Yrosine hydroxylase (TH) and growth associated protein 43 (GAP43) were detected by Immunofluorescence staining. Connexin43 and transforming growth factor beta receptor 1 (TGF-β1) were detected by western blot. Norepinephrine (NE) and BNP levels in blood and tissue were determined by ELISA. Cardiac function was assessed by echocardiography. Results: The ERP, APD90, QRS, QT and the Tend-Tpeak intervals in MI rats were all prolonged, but decreased after RTX treatment (n = 3, P<0.05). In contrast, the RR interval was shortened in the MI group, but prolonged in the MI+RTX group (n = 3, P<0.05). RTX treatment significantly reduced ventricular arrhythmias after MI. TH- and GAP43-positive nerve densities and TGF-β1, and cx-43 protein expression were up-regulated in the MI group compared to the sham group, and they were decreased in the MI+RTX group compared to the MI group (n = 3, P<0.05). RTX can decrease serum and tissue NE and BNP levels (n = 3, P<0.05). RTX pretreatment significantly decreased heart rate, HW/BW ratio and LVIDS, and increased LVEF andLVFS values (n = 3, P<0.05). Conclusion: RTX improved cardiac dysfunction, ventricular electrophysiologic properties, and sympathetic nerve remodeling in rats with MI by inhibiting the excessive cardiac sympathetic drive. 相似文献
13.
Hannah C. Nordhues Anjali Bhagra Natya N. Stroud Jennifer A. Vencill Carol L. Kuhle 《Mayo Clinic proceedings. Mayo Clinic》2021,96(7):1907-1920
The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less susceptible to severe illness. However, sex-disaggregated data are incomplete, leaving room for misinterpretation, and focusing only on biologic sex underestimates the gendered impact of the pandemic on women. This narrative review summarizes what is known about gender disparities during the COVID-19 pandemic and the economic, domestic, and health burdens along with overlapping vulnerabilities related to the pandemic. In addition, this review outlines recommended strategies that advocacy groups, community leaders, and policymakers should implement to mitigate the widening gender disparities related to COVID-19. 相似文献
14.
15.
16.
17.
IntroductionHip displacement is common in cerebral palsy (CP) and is related to the severity of neurological and functional impairment. It is a silent, but progressive disease, and can result in significant morbidity and decreased quality of life, if left untreated. The pathophysiology of hip displacement in CP is a combination of hip flexor-adductor muscle spasticity, abductor muscle weakness, and delayed weight-bearing, resulting in proximal femoral deformities and progressive acetabular dysplasia. Due to a lack of symptoms in the early stages of hip displacement, the diagnosis is easily missed. Awareness of this condition and regular surveillance by clinical examination and serial radiographs of the hips are the key to early diagnosis and treatment.Hip surveillance programmesSeveral population-based studies from around the world have demonstrated that universal hip surveillance in children with CP allows early detection of hip displacement and appropriate early intervention, with a resultant decrease in painful dislocations. Global hip surveillance models are based upon the patients’ age, functional level determined by the Gross Motor Function Classification system (GMFCS), gait classification, standardized clinical exam, and radiographic indices such as the migration percentage (MP), as critical indicators of progressive hip displacement.ConclusionDespite 25 years of evidence showing the efficacy of established hip surveillance programmes, there is poor awareness among healthcare professionals in India about the importance of regular hip surveillance in children with CP. There is a need for professional organizations to develop evidence-based guidelines for hip surveillance which are relevant to the Indian context. 相似文献
18.
19.
Jesus K Yamamoto-Furusho Norma N Parra-Holgu n 《World journal of gastroenterology : WJG》2021,27(48):8242-8261
Inflammatory bowel disease (IBD) is a chronic disease that requires chronic treatment throughout the evolution of the disease, with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn´s disease. The anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment, so there is a need to develop new therapies and markers of treatment response. Various pathways involved in the development of the disease are known and the new therapies have focused on blocking the inflammatory process at the gastrointestinal level by oral, intravenous, subcutaneous, and topical route. All these new therapies can lead to more personalized treatments with higher success rates and fewer relapses. These treatments have not only focused on clinical remission, but also on achieving macroscopic changes at the endoscopic level and microscopic changes by achieving mucosal healing. These treatments are mainly based on modifying signaling pathways, by blocking receptors or ligands, reducing cell migration and maintaining the integrity of the epithelial barrier. Therefore, this review presents the efficacy and safety of the new treatments that are currently under study and the advances that have been made in this area in recent years. 相似文献