全文获取类型
收费全文 | 6991篇 |
免费 | 343篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 138篇 |
儿科学 | 114篇 |
妇产科学 | 75篇 |
基础医学 | 958篇 |
口腔科学 | 179篇 |
临床医学 | 470篇 |
内科学 | 1869篇 |
皮肤病学 | 60篇 |
神经病学 | 472篇 |
特种医学 | 281篇 |
外科学 | 994篇 |
综合类 | 29篇 |
预防医学 | 192篇 |
眼科学 | 254篇 |
药学 | 626篇 |
中国医学 | 9篇 |
肿瘤学 | 645篇 |
出版年
2023年 | 46篇 |
2022年 | 72篇 |
2021年 | 103篇 |
2020年 | 67篇 |
2019年 | 87篇 |
2018年 | 95篇 |
2017年 | 60篇 |
2016年 | 125篇 |
2015年 | 113篇 |
2014年 | 140篇 |
2013年 | 167篇 |
2012年 | 247篇 |
2011年 | 275篇 |
2010年 | 185篇 |
2009年 | 138篇 |
2008年 | 291篇 |
2007年 | 281篇 |
2006年 | 279篇 |
2005年 | 318篇 |
2004年 | 312篇 |
2003年 | 308篇 |
2002年 | 298篇 |
2001年 | 307篇 |
2000年 | 300篇 |
1999年 | 254篇 |
1998年 | 91篇 |
1997年 | 65篇 |
1996年 | 67篇 |
1995年 | 55篇 |
1994年 | 51篇 |
1993年 | 40篇 |
1992年 | 200篇 |
1991年 | 161篇 |
1990年 | 169篇 |
1989年 | 163篇 |
1988年 | 158篇 |
1987年 | 148篇 |
1986年 | 128篇 |
1985年 | 109篇 |
1984年 | 95篇 |
1983年 | 69篇 |
1982年 | 42篇 |
1981年 | 39篇 |
1979年 | 75篇 |
1978年 | 54篇 |
1976年 | 44篇 |
1972年 | 44篇 |
1971年 | 41篇 |
1970年 | 42篇 |
1968年 | 45篇 |
排序方式: 共有7365条查询结果,搜索用时 0 毫秒
31.
Hirotsugu Kojima Syunji Sasaki Tetsuya Tamaki Hiroshi Kameda Satoru Yamasaki Michio Kimura 《Medical Electron Microscopy》1994,27(2):149-158
An ultrastructural study was undertaken concerning morphological changes within the autografted patellar tendon (PT) after
being transplanted to the anterior cruciate ligament (ACL) in mongrel dogs. After 4 weeks, the arrangements of both large
and small collagen fibrils in the PT graft became disordered, and the number of inflammatory cells increased. However, the
same PT grafts revealed postsurgical signs of newly-produced collagen fibrils around activated fibroblasts at 12 to 24 weeks.
At 52 weeks after the transplantation, small collagen fibrils increased in both number and density, showing a remarkable morphological
similarity to the collagen fibrils of normal ACL. These data indicate that the characteristics of the PT graft eventually
resemble those of a normal ACL.
This paper was presented in part at the Combined Meeting of the Orthopedic Research Societies of the USA, Japan and Canada
in Banff, Alberta, Canada, October, 1991. 相似文献
32.
33.
T Aoyagi T Aoyama F Kojima N Matsuda M Maruyama M Hamada T Takeuchi 《The Journal of antibiotics》1992,45(9):1385-1390
Benastatins have been isolated as part of a program designed to find microorganism-produced inhibitors of glutathione S-transferase from Streptomyces sp. MI384-DF12. They were purified by chromatography of reversed-phase silica gel, silica gel and Capcell Pak C18 (HPLC) followed by solvent extraction and then isolated as yellow powders. Benastatins A and B have the molecular formulae, C30H28O7 and C30H30O7, respectively. They were competitive with 3,4-dichloronitrobenzene as the substrate, and the inhibition constants (Ki) of benastatins A and B were 5.0 x 10(-6) and 3.7 x 10(-6), respectively. 相似文献
34.
Tatsuo Uchida Takahiko Tokumaru Hiroshi Kojima Katsura Nakagawaji Munehisa Imaizumi Toshio Abe 《Surgery today》1992,22(3):265-268
A 36 year old woman was admitted to our department because of a chest X-ray which showed multiple developing shadows. She underwent bilateral exploratory thoracotomies and a total 5 tumors were resected and pathologically diagnosed as benign metastasizing leiomyoma, the largest of which was positive for the progesterone receptor and negative for the estrogen receptor. A histogram of this tumor using a flow cytometer showed a diploid pattern and 4.6 percent of the S phase which was not more than that of a leiomyoma of the uterus from another patient. Two months later, she underwent a hysterectomy and bilateral salpingo-oophorectomy for treatment of the positive progesterone receptor in the pulmonary lesions. The resected uterine myoma and normal myometrium showed positive estrogen and progesterone receptors. For the subsequent 28 months she has been free of any further symptoms. Benign metastasizing leiomyoma of the uterus is a rare disease and very interesting because of its histological benignity and hormonal dependency. However, according to the literature, it is often confused in entity due to the fact that normal lung tissue also possesses hormone receptors. Considering our data on hormone receptors, it is rational to think that multiple leiomyomatous lesions in the lung should only be diagnosed as benign metastasizing leiomyomas when they possess positive estrogen and progesterone receptors. 相似文献
35.
A 72-year-old male was admitted because of right lower quadrant pain, Barium enema and total colonoscopy disclosed multiple colon cancers and sequentially, a subtotal colectomy was performed. The resected specimen demonstrated 3 advanced carcinomas and an adenomatous cancer with additional multiple polyps. Investigation of his family history revealed that his mother and his elder sister had died of uterine cancer, and that his elder brother, his nephew, and his niece had been operated on for colorectal cancer. We thus supposed a case of "Cancer Family Syndrome" presenting multiple neoplasms of the colon. 相似文献
36.
Electron microscopic and immunohistochemical studies were carried out on materials obtained from three patients of gamma heavy chain disease ( λ -HCD). Electron microscopically, proliferating cells showed various stages of maturation from immunoblast to plasma cell, and the majority of proliferating cells were proplasmacytes and plasma cells. From the intracytoplasmic immunoglobulin studies by immunoperoxidase method (PAP method) and electron microscopical enzyme-labeled antibody technique, proliferating cells, such as the immunoblast, plasmablast, proplasmacyte, and plasma cell, showed positive reaction to anti- λ -heavy chain serum and anti-Fc fragment (IgG) serum, and also in a third case with Bence Jones protein, proliferating cells showed positive reaction to anti-K light chain serum. We would conclude that proliferating cells in λ -HCD might be a single clone proliferation of B-cell synthesizing λ -HCD protein, and the predominant proliferation cells are proplasmacytes and plasma cells situated near mature plasma cells in the B-cell line. 相似文献
37.
Yoshida C Suzukawa K Katsura Y Shimizu S Mukai HY Hasegawa Y Imagawa S Kojima H Nagasawa T 《Cancer Genetics and Cytogenetics》2004,150(1):62-65
We describe the case of a 40-year-old man whose disease was initially diagnosed as acute myelocytic leukemia. The patient achieved remission with chemotherapy, but relapsed shortly afterwards with an acute T-cell lymphoblastic leukemia. He died of intracranial bleeding. Karyotyping analysis showed a del(9p?) as a common abnormality in the leukemic cells at onset and relapse. Fluorescence in situ hybridization analysis demonstrated allelic loss of the CDKN2A gene in cells from both stages of the disease. At relapse the leukemia cells had additional abnormalities such as add(1)(p36) and del(12)(p11). We postulate that the loss of CDKN2A is involved in leukemogenesis but does not determine the lineage of the leukemic cells. Instead, abnormalities of genes at 1p36, 12p11, or both may be involved in driving a lymphoid phenotype. 相似文献
38.
39.
Detection of tumour necrosis factor/cachectin in pleural effusion of patients with lung cancer. 总被引:1,自引:0,他引:1 下载免费PDF全文
Y Ishii Y Uchiyama S Hasegawa T Kinoshita K Mitsui H Kojima T Fujita 《Clinical and experimental immunology》1990,80(3):350-353
We have found that the pleural effusion obtained from a patient with lung cancer (adenocarcinoma) has cytotoxic activity against the patient's lung cancer cells. This finding occurred in the course of establishing a lung cancer cell line from the patient's pleural effusion. The cytotoxic factor was partially purified from the pleural effusion and characterized. It had cytotoxicity against L-929 mouse fibroblasts in the standard 18-h killing assay of tumour necrosis factor (TNF). By molecular sieving chromatography, the activity appeared at molecular weight of 50,000. This activity was completely blocked by a monoclonal antibody to TNF. From these results, we conclude that the cytotoxic factor in the pleural effusion is TNF. The concentration of TNF in the pleural effusion was 34.5 pg/ml by radioimmunoassay. In addition, we detected TNF activity and protein in two other cases of carcinomatous pleural effusion. Therefore, it would appear that in vivo TNF displays cytotoxic activity against cancer cells. 相似文献
40.