全文获取类型
收费全文 | 24375篇 |
免费 | 8403篇 |
国内免费 | 163篇 |
专业分类
耳鼻咽喉 | 223篇 |
儿科学 | 547篇 |
妇产科学 | 469篇 |
基础医学 | 4926篇 |
口腔科学 | 955篇 |
临床医学 | 3764篇 |
内科学 | 6117篇 |
皮肤病学 | 532篇 |
神经病学 | 1911篇 |
特种医学 | 1715篇 |
外科学 | 5861篇 |
综合类 | 277篇 |
一般理论 | 11篇 |
预防医学 | 2831篇 |
眼科学 | 416篇 |
药学 | 1262篇 |
1篇 | |
中国医学 | 11篇 |
肿瘤学 | 1112篇 |
出版年
2021年 | 348篇 |
2020年 | 260篇 |
2018年 | 333篇 |
2017年 | 365篇 |
2016年 | 535篇 |
2015年 | 860篇 |
2014年 | 1461篇 |
2013年 | 2092篇 |
2012年 | 630篇 |
2011年 | 534篇 |
2010年 | 1151篇 |
2009年 | 1256篇 |
2008年 | 494篇 |
2007年 | 296篇 |
2006年 | 423篇 |
2005年 | 347篇 |
2004年 | 308篇 |
2002年 | 291篇 |
2001年 | 439篇 |
2000年 | 353篇 |
1999年 | 559篇 |
1998年 | 793篇 |
1997年 | 759篇 |
1996年 | 805篇 |
1995年 | 768篇 |
1994年 | 654篇 |
1993年 | 605篇 |
1992年 | 592篇 |
1991年 | 565篇 |
1990年 | 504篇 |
1989年 | 594篇 |
1988年 | 620篇 |
1987年 | 606篇 |
1986年 | 562篇 |
1985年 | 598篇 |
1984年 | 536篇 |
1983年 | 524篇 |
1982年 | 585篇 |
1981年 | 548篇 |
1980年 | 528篇 |
1979年 | 507篇 |
1978年 | 500篇 |
1977年 | 502篇 |
1976年 | 436篇 |
1975年 | 391篇 |
1974年 | 354篇 |
1973年 | 333篇 |
1972年 | 335篇 |
1971年 | 304篇 |
1970年 | 256篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
961.
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: ten.tsacmoc@cvSxRcnO; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: ten.retrahc@ruofddaw.
Name: LenvatinibSynonyms: Lenvima; E7080 相似文献
962.
963.
964.
Francisco Rogerlandio Martins-Melo Marta Cristhiany Cunha Pinheiro Alberto Novaes Ramos Jr Carlos Henrique Alencar Fernando Schemelzer de Moraes Bezerra Jorg Heukelbach 《Emerging infectious diseases》2015,21(10):1820-1823
We analyzed spatiotemporal patterns of 8,756 schistosomiasis-related deaths in Brazil during 2000–2011 and identified high-risk clusters of deaths, mainly in highly schistosomiasis-endemic areas along the coast of Brazil’s Northeast Region. Schistosomiasis remains a neglected public health problem with a high number of deaths in disease-endemic and emerging focal areas. 相似文献
965.
Kwame Owusu-Edusei Jr. Harrell W. Chesson Thomas L. Gift Robert C. Brunham Gail Bolan 《Emerging infectious diseases》2015,21(6):960-968
We explored potential cost-effectiveness of a chlamydia vaccine for young women in the United States by using a compartmental heterosexual transmission model. We tracked health outcomes (acute infections and sequelae measured in quality-adjusted life-years [QALYs]) and determined incremental cost-effectiveness ratios (ICERs) over a 50-year analytic horizon. We assessed vaccination of 14-year-old girls and catch-up vaccination for 15–24-year-old women in the context of an existing chlamydia screening program and assumed 2 prevaccination prevalences of 3.2% by main analysis and 3.7% by additional analysis. Estimated ICERs of vaccinating 14-year-old girls were $35,300/QALY by main analysis and $16,200/QALY by additional analysis compared with only screening. Catch-up vaccination for 15–24-year-old women resulted in estimated ICERs of $53,200/QALY by main analysis and $26,300/QALY by additional analysis. The ICER was most sensitive to prevaccination prevalence for women, followed by cost of vaccination, duration of vaccine-conferred immunity, and vaccine efficacy. Our results suggest that a successful chlamydia vaccine could be cost-effective. 相似文献
966.
967.
Rodolfo Gonzalez Camargo Daniela Mendes dos Reis Riccardi Henrique Quintas Teixeira Ribeiro Luiz Carlos Carnevali Jr. Emidio Marques de Matos-Neto Lucas Enjiu Rodrigo Xavier Neves Joanna Darck Carola Correia Lima Raquel Galv?o Figuerêdo Paulo Sérgio Martins de Alcantara Linda Maximiano José Otoch Miguel Luiz Batista Jr. Gerhard Püschel Marilia Seelaender 《Nutrients》2015,7(6):4465-4479
968.
The essential trace element, selenium (Se), has multiple biological activities, which depend on the level of Se intake. Relatively low Se intakes determine the expression of selenoenzymes in which it serves as an essential constituent. Higher intakes have been shown to have anti-tumorigenic potential; and very high Se intakes can produce adverse effects. This hierarchy of biological activities calls for biomarkers informative at different levels of Se exposure. Some Se-biomarkers, such as the selenoproteins and particularly GPX3 and SEPP1, provide information about function directly and are of value in identifying nutritional Se deficiency and tracking responses of deficient individuals to Se-treatment. They are useful under conditions of Se intake within the range of regulated selenoprotein expression, e.g., for humans <55 μg/day and for animals <20 μg/kg diet. Other Se-biomarkers provide information indirectly through inferences based on Se levels of foods, tissues, urine or feces. They can indicate the likelihood of deficiency or adverse effects, but they do not provide direct evidence of either condition. Their value is in providing information about Se status over a wide range of Se intake, particularly from food forms. There is need for additional Se biomarkers particularly for assessing Se status in non-deficient individuals for whom the prospects of cancer risk reduction and adverse effects risk are the primary health considerations. This would include determining whether supranutritional intakes of Se may be required for maximal selenoprotein expression in immune surveillance cells. It would also include developing methods to determine low molecular weight Se-metabolites, i.e., selenoamino acids and methylated Se-metabolites, which to date have not been detectable in biological specimens. Recent analytical advances using tandem liquid chromatography-mass spectrometry suggest prospects for detecting these metabolites. 相似文献
969.
Synthesis of stable isotope‐labeled epothilone D using a degradation–reconstruction approach 下载免费PDF全文
Richard C. Burrell Wesley A. Turley Samuel J. Bonacorsi Jr. 《Journal of labelled compounds & radiopharmaceuticals》2015,58(9):361-369
The stabilization of microtubules using epothilones represents a novel mechanism of action to treat Alzheimer's disease. Epothilone D is one such microtubule‐stabilizing drug that has been investigated by Bristol‐Myers Squibb. An important step in the development process was the synthesis of a stable isotope‐labeled analog for use in bioanalytical assays to accurately quantify the concentration of the drug in biological samples. A novel synthetic route to stable isotope‐labeled epothilone D is described. The synthetic route was based on a strategy to degrade epothilone B and then use that key intermediate to reconstruct stable isotope‐labeled epothilone D. Epothilone B was treated with potassium osmate and sodium periodate. The thiazole moiety in epothilone B was efficiently cleaved to give (1S,3S,7S,10R,11S,12S,16R)‐3‐acetyl‐7,11‐dihydroxy‐8,8,10,12,16‐pentamethyl‐4,17‐dioxabicyclo[14.1.0]heptadecane‐5,9‐dione. The epoxide in the macrocyclic ring of that intermediate was cleanly removed by treatment with tungsten hexachloride and n‐butyllithium to give the corresponding olefin (4S,7R,8S,9S,16S,Z)‐16‐acetyl‐4,8‐dihydroxy‐5,5,7,9,13‐pentamethyloxacyclohexadec‐13‐ene‐2,6‐dione. Bis(triethylsilyl) protection produced (4S,7R,8S,9S,16S,Z)‐16‐acetyl‐5,5,7,9,13‐pentamethyl‐4,8‐bis(triethylsilyloxy)‐oxacyclohexadec‐13‐ene‐2,6‐dione. This intermediate was coupled to a stable isotope‐labeled thiazole using a Wittig reaction as the key step to provide 13C5, 15N‐labeled epothilone D. In summary, the synthesis was completed in nine total steps, only six of which involved isotopically labeled reagents. A total of 168 mg of 13C5, 15N‐labeled epothilone D was prepared in an 8% overall yield from 13C2, 15N‐labeled thioacetamide and 13C3‐labeled ethyl bromopyruvate. 相似文献
970.
Increased plasma levels of soluble TNF receptors 1 and 2 in bipolar depression and impact of lithium treatment 下载免费PDF全文