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51.
Jost Jaeger 《Journal of cancer research and clinical oncology》1954,59(6):623-639
Zusammenfassung Mittels der modifizierten Imprägnationsmethode nachBodian gelang es, argyrophile Körnchen in den epithelialen Zellen zweier Bronchuskarzinoide darzustellen, in einem der Fälle auch in hämatogenen Fernmetastasen. Man kann in diesem Befund eine weitere Analogie zwischen den Bronchus- und Darmkarzinoiden erblicken, denen die Bronchuskarzinoide auch sonst in Struktur (s. Abb. 3a und b) und klinischem Verhalten weitgehend entsprechen. Die Bezeichnung Karzinoid ist also treffender als die Bezeichnung Bronchialadenom, eventuell unter Beifügung vom karzinoiden Typ. Anhangseeise wird eine Übersicht über die in der Literatur mitgeteilten Fälle von Bronchuskarzinoiden gegeben.Mit 5 Textabbildungen 相似文献
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Lauren G. Kanapka R. Paul Wadwa Marc D. Breton Katrina J. Ruedy Laya Ekhlaspour Gregory P. Forlenza Eda Cengiz Melissa J. Schoelwer Emily Jost Lori Carria Emma Emory Liana J. Hsu Stuart A. Weinzimer Mark D. DeBoer Bruce A. Buckingham Mary Oliveri Craig Kollman Betsy B. Dokken Daniel Cheravvsky Roy W. Beck 《Diabetes care》2021,44(2):473
OBJECTIVETo further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes.RESEARCH DESIGN AND METHODSAfter a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented pump (SAP) therapy in 101 children 6–13 years old with type 1 diabetes, 22 participants in the SAP group initiated use of the CLC system (referred to as SAP-CLC cohort), and 78 participants in the CLC group continued use of CLC (CLC-CLC cohort) for 12 weeks.RESULTSIn the SAP-CLC cohort, mean percentage of time in range 70–180 mg/dL (TIR) increased from 55 ± 13% using SAP during the RCT to 65 ± 10% using CLC (P < 0.001), with 36% of the cohort achieving TIR >70% plus time <54 mg/dL <1% compared with 14% when using SAP (P = 0.03). Substantial improvement in TIR was seen after the 1st day of CLC. Time <70 mg/dL decreased from 1.80% to 1.34% (P < 0.001). In the CLC-CLC cohort, mean TIR increased from 53 ± 17% prerandomization to 67 ± 10% during the RCT and remained reasonably stable at 66 ± 10% through the 12 weeks post-RCT. No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either cohort.CONCLUSIONSThis further evaluation of the Control-IQ CLC system supports the findings of the preceding RCT that use of a closed-loop system can safely improve glycemic control in children 6–13 years old with type 1 diabetes from the 1st day of use and demonstrates that these improvements can be sustained through 28 weeks of use. 相似文献
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Background
Age-related macular degeneration (AMD) is one of the most common causes of irreversible blindness worldwide. We assessed its epidemiology and related factors in China.Methods
Through population-based studies and clinical investigations, we assessed prevalence, incidence, and associated factors of AMD. The population-based investigations included several epidemiological surveys of ophthalmological and systemic diseases in China. The clinical studies consisted of biochemical examinations of aqueous humour samples obtained from patients undergoing intraocular surgery.Findings
In the Beijing Eye Public Health Care Study, by use of a telemedicine approach, macular degeneration was identified to have caused visual impairment in 2700 (0·48%) of 562 788 elderly study participants (aged 55–85 years). In the Beijing Eye Study study, including 4439 participants and surveys done three times in 5-year intervals over a total period of 10 years, the prevalence of early AMD was 1·4%, late AMD was 0·20%, and exudative AMD was 0·10% per individual. Factors linearly association with AMD prevalence were older age (OR 1·06, 95% CI 1·04–1·08; p<0·0001), hyperopic refractive error (OR 1·16, 1·04–1·28; p=0·008), residence in a rural region (OR 0·33, 0·17–0·49; p<0·0001), and a lower level of education (OR 1·36, 1·07–1·65; p=0·01). The 5-year incidence of early AMD was 4·2% (SD 0·4, 95% CI 3·5–5·0), late AMD was 0·1% (SD 0·1, 0·0–0·2), and neovascular AMD was 0·1% (SD 0·1, 0·0–0·2). 5-year incidence was correlated with older age (odds ratio [OR] 1·03, 95% CI 1·01–1·06; p=0·01) and hyperopic refractive error (OR 1·15, 1·03–1·33; p=0·03). In participants with exudative AMD, as compared with control participants, intraocular concentrations of intercellular adhesion molecule-1 (844 pg/mL [SD 2073] vs 246 pg/mL [SD 206]; p=0·001) and soluble vascular cell adhesion molecule-1 (7978 pg/mL [SD 7120] vs 2999 pg/mL [SD 1426]; p=0·001) were significantly elevated. The concentration of MCP-1 decreased (p=0·009) with the type of subfoveal neovascular membrane (classic membrane type, occult membrane, retinal pigment epithelium detachment; p=0·009). In control participants, as compared with patients with neovascular AMD, the concentration of vascular endothelial growth factor (VEGF) was correlated with significantly shorter axial length (r ?0·58; p=0·008).Interpretation
Besides older age, hyperopic refractive error was the most important risk factor for prevalence and incidence of AMD in Chinese adults. The intraocular concentration of VEGF as a major AMD-associated growth factor decreased with increased axial length. The marked increase in myopia in the generation now aged younger than 30 years in China might be assumed to have a protective effect against AMD in the future.Funding
National Natural Science Foundation of China. 相似文献55.
56.
B. Bett M. McLaws C. Jost L. Schoonman F. Unger J. Poole M. L. Lapar E. S. Siregar M. Azhar M. M. Hidayat S. E. Dunkle J. Mariner 《Transboundary and Emerging Diseases》2015,62(2):163-173
We conducted an operational research study involving backyard and semicommercial farms on Java Island, Indonesia, between April 2008 and September 2009 to evaluate the effectiveness of two preventive mass vaccination strategies against highly pathogenic avian influenza (HPAI). One regimen used Legok 2003 H5N1 vaccine, while the other used both Legok 2003 H5N1 and HB1 Newcastle disease (ND) vaccine. A total of 16 districts were involved in the study. The sample size was estimated using a formal power calculation technique that assumed a detectable effect of treatment as a 50% reduction in the baseline number of HPAI‐compatible outbreaks. Within each district, candidate treatment blocks with village poultry populations ranging from 80 000 to 120 000 were created along subdistrict boundary lines. Subsequently, four of these blocks were randomly selected and assigned one treatment from a list that comprised control, vaccination against HPAI, vaccination against HPAI + ND. Four rounds of vaccination were administered at quarterly intervals beginning in July 2008. A vaccination campaign involved vaccinating 100 000 birds in a treatment block, followed by another 100 000 vaccinations 3 weeks later as a booster dose. Data on disease incidence and vaccination coverage were also collected at quarterly intervals using participatory epidemiological techniques. Compared with the unvaccinated (control) group, the incidence of HPAI‐compatible events declined by 32% (P = 0.24) in the HPAI‐vaccinated group and by 73% (P = 0.00) in the HPAI‐ and ND‐vaccinated group. The effect of treatment did not vary with time or district. Similarly, an analysis of secondary data from the participatory disease and response (PDSR) database revealed that the incidence of HPAI declined by 12% in the HPAI‐vaccinated group and by 24% in the HPAI + ND‐vaccinated group. The results suggest that the HPAI + ND vaccination significantly reduced the incidence of HPAI‐compatible events in mixed populations of semicommercial and backyard poultry. 相似文献
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59.
Kyoko Ohno-Matsui Pei-Chang Wu Kenji Yamashiro Kritchai Vutipongsatorn Yuxin Fang Chui Ming Gemmy Cheung Timothy Y. Y. Lai Yasushi Ikuno Salomon Yves Cohen Alain Gaudric Jost B. Jonas 《Investigative ophthalmology & visual science》2021,62(5)
Pathologic myopia is a major cause of visual impairment worldwide. Pathologic myopia is distinctly different from high myopia. High myopia is a high degree of myopic refractive error, whereas pathologic myopia is defined by a presence of typical complications in the fundus (posterior staphyloma or myopic maculopathy equal to or more serious than diffuse choroidal atrophy). Pathologic myopia often occurs in eyes with high myopia, however its complications especially posterior staphyloma can also occur in eyes without high myopia.Owing to a recent advance in ocular imaging, an objective and accurate diagnosis of pathologic myopia has become possible. Especially, optical coherence tomography has revealed novel lesions like dome-shaped macula and myopic traction maculopathy. Wide-field optical coherence tomography has succeeded in visualizing the entire extent of large staphylomas. The effectiveness of new therapies for complications have been shown, such as anti-VEGF therapies for myopic macular neovascularization and vitreoretinal surgery for myopic traction maculopathy.Myopia, especially childhood myopia, has been increasing rapidly in the world. In parallel with an increase in myopia, the prevalence of high myopia has also been increasing. However, it remains unclear whether or not pathologic myopia will increase in parallel with an increase of myopia itself. In addition, it has remained unclear whether genes responsible for pathologic myopia are the same as those for myopia in general, or whether pathologic myopia is genetically different from other myopia. 相似文献
60.
Diener Raphael Treder Maximilian Lauermann Jost Lennart Eter Nicole Alnawaiseh Maged 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2021,259(4):1061-1070
Graefe's Archive for Clinical and Experimental Ophthalmology - The present retrospective study was designed to test the hypothesis that the postoperative posterior to preoperative anterior... 相似文献