全文获取类型
收费全文 | 2429篇 |
免费 | 160篇 |
国内免费 | 23篇 |
专业分类
儿科学 | 64篇 |
妇产科学 | 21篇 |
基础医学 | 234篇 |
口腔科学 | 24篇 |
临床医学 | 237篇 |
内科学 | 392篇 |
皮肤病学 | 26篇 |
神经病学 | 181篇 |
特种医学 | 310篇 |
外国民族医学 | 1篇 |
外科学 | 296篇 |
综合类 | 41篇 |
一般理论 | 3篇 |
预防医学 | 67篇 |
眼科学 | 519篇 |
药学 | 119篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2022年 | 16篇 |
2021年 | 29篇 |
2020年 | 20篇 |
2019年 | 22篇 |
2018年 | 41篇 |
2017年 | 36篇 |
2016年 | 47篇 |
2015年 | 42篇 |
2014年 | 67篇 |
2013年 | 78篇 |
2012年 | 93篇 |
2011年 | 124篇 |
2010年 | 90篇 |
2009年 | 67篇 |
2008年 | 108篇 |
2007年 | 115篇 |
2006年 | 107篇 |
2005年 | 100篇 |
2004年 | 98篇 |
2003年 | 105篇 |
2002年 | 76篇 |
2001年 | 51篇 |
2000年 | 63篇 |
1999年 | 74篇 |
1998年 | 62篇 |
1997年 | 70篇 |
1996年 | 53篇 |
1995年 | 54篇 |
1994年 | 35篇 |
1993年 | 38篇 |
1992年 | 40篇 |
1991年 | 52篇 |
1990年 | 49篇 |
1989年 | 35篇 |
1988年 | 50篇 |
1987年 | 47篇 |
1986年 | 40篇 |
1985年 | 32篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 26篇 |
1981年 | 20篇 |
1980年 | 27篇 |
1979年 | 21篇 |
1978年 | 15篇 |
1977年 | 29篇 |
1976年 | 18篇 |
1975年 | 18篇 |
1973年 | 9篇 |
1972年 | 8篇 |
排序方式: 共有2612条查询结果,搜索用时 0 毫秒
991.
The hallmarks of the myoclonic epilepsy with ragged red fibers (MERRF) syndrome are myoclonic epilepsy, ataxia and ragged red fibres detected on muscle biopsy. We present a case of a 25-year-old male who first presented to his general practitioner at the age of 22 years with myoclonic jerks affecting the arms and legs, fatigue and mild ataxia. He was found to carry an A>G transition at nucleotide 8344 in mitochondrial DNA. This mutation is the most common cause of the MERRF syndrome, found in more than 80% of affected patients. Our patient had the diagnosis tattooed on his arm, both out of frustration at how few people had heard of it, and as a way of accepting that his condition was a part of who he was. Although the MERRF syndrome is one of the more common forms of mitochondrial encephalomyopathy, with a prevalence estimated at between 0.25 and 0.39 per 100,000, it is still a rare disorder. We are always striving to increase the public's understanding of these important conditions. Our patient has perhaps helped more than most towards this aspiration. 相似文献
992.
Véronique Marsaud Guergana Tchakarska Geoffroy Andrieux Jian-Miao Liu Doulaye Dembele Bernard Jost Joanna Wdzieczak-Bakala Jack-Michel Renoir Brigitte Sola 《Molecular cancer》2010,9(1):103
Background
Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b. Both isoforms are present in MM cell lines and primary cells but their relative role in the tumorigenic process is still elusive. 相似文献993.
Y90‐Ibritumomab tiuxetan (Y90‐IT) and high‐dose melphalan as conditioning regimen before autologous stem cell transplantation for elderly patients with lymphoma in relapse or resistant to chemotherapy: a feasibility trial (SAKK 37/05)
下载免费PDF全文
![点击此处可从《Hematological oncology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Michèle Voegeli Stephanie Rondeau Simona Berardi Vilei Erika Lerch Luciano Wannesson Thomas Pabst Jochen Rentschler Mario Bargetzi Lorenz Jost Nicolas Ketterer Angelika Bischof Delaloye Michele Ghielmini 《Hematological oncology》2017,35(4):576-583
Standard conditioning regimens for autologous stem cell transplantation (ASCT) are often not tolerated by elderly patients, on one hand. Single high‐dose melphalan, on the other hand, has been shown to be safe and active as a pretransplant preparative regimen in elderly patients. Y90‐Ibritumomab tiuxetan (Y90‐IT) is well tolerated and feasible in the transplantation setting. We therefore investigated the combination of high‐dose melphalan and Y90‐IT as a conditioning regimen for patients ≥65 years of age. Patients with relapsed or resistant CD20‐positive lymphoma in remission after salvage chemotherapy could be enrolled. High‐dose therapy consisted of standard dose Y90‐IT (0.4‐mCi/kg body weight) followed by melphalan at escalating doses (100, 140, 170 and 200 mg/m2) and ASCT. The primary objective was to identify the maximum tolerated dose; secondary end points were complete response (CR) rate 100 days after transplantation and toxicity. Twenty patients (median age 72 years) were included. No DLT occurred at any dose level. Thirteen patients completed the treatment, 11 were evaluable for response. Seven patients did not complete treatment because of mobilization failure (n = 3), progressive disease (n = 2), worsening of cardiac function (n = 1), and grade 3 dyspnea (n = 1). Seven patients achieved a CR/complete remission/unconfirmed (CRu) and 2 had stable disease. Five out of 7 responding patients were still alive more than 3 years after transplantation. The 2 patients with SD had a long‐term survival of 3 and 5 years, respectively. Nonhematological grade 3 or higher treatment related adverse events (AEs) were infection (n = 6), including 2 cases of febrile neutropenia, diarrhea (n = 3), mucositis, anorexia, viral hepatitis, hypokalemia, dehydration, and multiorgan failure (n = 1 for each). The combination of Y90‐IT and high‐dose melphalan is feasible before ASCT for elderly patients, with promising activity and manageable toxicity. 相似文献
994.
Kaifie A. Isfort S. Gattermann N. Hollburg W. Klausmann M. Wolf D. Maintz C. Hänel M. Goekkurt E. Göthert J. R. Platzbecker U. Geer T. Parmentier S. Jost E. Serve H. Ehninger G. Berdel W. E. Brümmendorf T. H. Koschmieder Steffen 《Annals of hematology》2016,95(9):1399-1410
Annals of Hematology - Philadelphia-negative myeloproliferative neoplasms (MPN) comprise a heterogeneous group of chronic hematological malignancies with significant variations in clinical... 相似文献
995.
Left coronary artery compression syndrome is an uncommon entity and characterized by compression of the LMCA in-between the aorta and an enlarged main pulmonary arterial trunk. It is usually associated with a congenital cardiac defect. Cardiac 64-slice MDCT provides a non-invasive and an accurate method for assessing the degree of dynamic LMCA compression throughout the cardiac cycle, its angulation relative to the left sinus of Valsalva and depiction of pulmonary pathology, making it a valuable tool in the workup of patients suspected of left coronary artery compression. 相似文献
996.
U. Meyding-Lamadé E. M. Craemer E. K. Lamadé B. Bassa K. Enk H. Ilsen C. Jacobi V. Jost M. W. Lorenz C. Mohs C. Schwark B. Zimmerlein T. Gottschalk W. Hacke B. Kress 《Der Nervenarzt》2017,88(2):141-147
Background
Specialized neurological treatment decreases the mortality and morbidity of stroke patients. In many regions of the world an extensive coverage is not available. The cooperation between the Krankenhaus Nordwest (KHNW, Frankfurt, Germany) and the Government of Brunei Darussalam describes the set-up process of a specialized neurological center, including stroke unit, science and rehabilitation center.Aim
The aim of this project called to teach to treat – to treat to teach was to set up a center of excellence in neurology in Brunei Darussalam over a distance of 12,000?km. Treatment options were elucidated by teaching and taught by case examples.Material and methods
The construction of the Brunei Neuroscience Stroke and Rehabilitation Center (BNSRC) began in July 2010. To overcome the large distance between the department of neurology and neuroradiology at the KHNW and the BNSRC, a telemedical network was established. We provided daily teleteaching for all professions involved in patient care as well as 24/7 availability of teleneurological services from Germany to support the local team on site.Results
In the BNSRC unit over 1000 patients with ischemic and hemorrhagic stroke and all the various acute neurological conditions were treated from July 2010 until July 2016 as inpatients and over 5000 were treated as outpatients. Since 2010, a total of 52 patients with stroke were treated by thrombolysis within the thrombolytic window and 81 hemicraniectomies were performed.Conclusion
The project has shown that it is possible to convey specialized neurological knowledge over large distances to provide significant benefits for patients and caregivers.997.
998.
999.
For detection of left ventricular (LV) systolic dysfunction in the outpatient setting, simultaneous electrocardiographic and heart sound data have been shown to be helpful. In 161 patients with suspected or known cardiac disease, echocardiography and acoustic cardiography were performed. Acoustic cardiographic parameters correlated to echocardiography included: presence or absence of S3, electromechanical activation time (EMAT), LV systolic time (LVST), and EMAT/LVST. LV ejection fraction was >or=50% in 82 patients (S3 present in 9.8%) and <50% in 79 patients (S3 present in 30.4%; the <50% group also had a greater EMAT, EMAT/LVST, and lower mean LVST [p<0.05]). Patients with an S3 had a lower ejection fraction, larger mean left atrial and LV dimensions, and an increased proportion of diastolic dysfunction. Acoustic cardiography allows reliable detection of the S3, which correlates with echocardiographic evidence of impaired LV function, and the EMAT/LVST ratio reflects reduced ejection fraction, providing an affordable, accessible means to assess LV dysfunction in the outpatient setting. 相似文献
1000.
Anticoagulation practices in adults with congenital heart disease and atrial arrhythmias in Switzerland
下载免费PDF全文
![点击此处可从《Congenital heart disease》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ketina Arslani Lukas Notz Marzena Zurek Matthias Greutmann Markus Schwerzmann Judith Bouchardy Reto Engel Christine Attenhofer Jost Daniel Tobler 《Congenital heart disease》2018,13(5):678-684
Background: In adults with congenital heart disease (CHD) and atrial arrhythmias, recommendations for thromboprophylaxis are vague and evidence is lacking. We aimed to identify factors that
influence decision-making in daily practice.
Methods: From the Swiss Adult Congenital HEart disease Registry (SACHER) we identified 241 patients with either atrial fibrillation (Afib) or atrial flutter/intraatrial reentrant tachycardia (Aflut/ IART). The mode of anticoagulation was reviewed. Logistic regression models were used to assess factors that were associated with oral anticoagulation therapy.
Results: Compared with patients with Aflut/IART, patients with Afib were older (51 ± 16.1 vs 37 ± 16 years, P < .001) and had a higher CHA2DS2-VASc (P < .001) and HAS-BLED scores (P = .005). Patients with Afib were more likely on oral anticoagulation than patients with Aflut/IART (67% vs 43%, P < .001). In a multivariate logistic regression model, age [odds ratio (OR) 1.03 per year, 95%CI (1.01-1.05), P = .019], atrial fibrillation [OR 2.75, 95%CI (1.30-5.08), P = .007], nonparoxysmal atrial arrhythmias [OR 5.33, 95%CI (2.21-12.85)], CHA2DS2-VASc-Score >1 [OR 2.93, 95%CI (1.87-4.61), P < .001], and Fontan palliation [OR 17.5, 95%CI (5.57-54.97), P < .001] were independently associated with oral anticoagulation treatment, whereas a HAS-BLED score >1 was associated with absence of thromboprophylaxis [OR 0.32, 95%CI (0.17-0.60), P < .001].
Conclusions: In this multicenter study, age, type, and duration of atrial arrhythmias, CHA2DS2- VASc and HAS-BLED scores as well as a Fontan palliation had an impact on the use of thromboprophylaxis in adult CHD patients with atrial arrhythmias. In daily practice, anticoagulation strategies differ between patients with Afib and those with Aflut/IART. Prospective observational studies are necessary to clarify whether this attitude is justified. 相似文献
Methods: From the Swiss Adult Congenital HEart disease Registry (SACHER) we identified 241 patients with either atrial fibrillation (Afib) or atrial flutter/intraatrial reentrant tachycardia (Aflut/ IART). The mode of anticoagulation was reviewed. Logistic regression models were used to assess factors that were associated with oral anticoagulation therapy.
Results: Compared with patients with Aflut/IART, patients with Afib were older (51 ± 16.1 vs 37 ± 16 years, P < .001) and had a higher CHA2DS2-VASc (P < .001) and HAS-BLED scores (P = .005). Patients with Afib were more likely on oral anticoagulation than patients with Aflut/IART (67% vs 43%, P < .001). In a multivariate logistic regression model, age [odds ratio (OR) 1.03 per year, 95%CI (1.01-1.05), P = .019], atrial fibrillation [OR 2.75, 95%CI (1.30-5.08), P = .007], nonparoxysmal atrial arrhythmias [OR 5.33, 95%CI (2.21-12.85)], CHA2DS2-VASc-Score >1 [OR 2.93, 95%CI (1.87-4.61), P < .001], and Fontan palliation [OR 17.5, 95%CI (5.57-54.97), P < .001] were independently associated with oral anticoagulation treatment, whereas a HAS-BLED score >1 was associated with absence of thromboprophylaxis [OR 0.32, 95%CI (0.17-0.60), P < .001].
Conclusions: In this multicenter study, age, type, and duration of atrial arrhythmias, CHA2DS2- VASc and HAS-BLED scores as well as a Fontan palliation had an impact on the use of thromboprophylaxis in adult CHD patients with atrial arrhythmias. In daily practice, anticoagulation strategies differ between patients with Afib and those with Aflut/IART. Prospective observational studies are necessary to clarify whether this attitude is justified. 相似文献