全文获取类型
收费全文 | 50431篇 |
免费 | 3169篇 |
国内免费 | 166篇 |
专业分类
耳鼻咽喉 | 666篇 |
儿科学 | 1214篇 |
妇产科学 | 1036篇 |
基础医学 | 6902篇 |
口腔科学 | 3087篇 |
临床医学 | 3661篇 |
内科学 | 11572篇 |
皮肤病学 | 1190篇 |
神经病学 | 4019篇 |
特种医学 | 1175篇 |
外国民族医学 | 1篇 |
外科学 | 6307篇 |
综合类 | 296篇 |
一般理论 | 16篇 |
预防医学 | 4712篇 |
眼科学 | 1112篇 |
药学 | 3544篇 |
中国医学 | 351篇 |
肿瘤学 | 2905篇 |
出版年
2023年 | 380篇 |
2022年 | 745篇 |
2021年 | 1772篇 |
2020年 | 1079篇 |
2019年 | 1465篇 |
2018年 | 1784篇 |
2017年 | 1233篇 |
2016年 | 1303篇 |
2015年 | 1580篇 |
2014年 | 1963篇 |
2013年 | 2594篇 |
2012年 | 3752篇 |
2011年 | 4112篇 |
2010年 | 2207篇 |
2009年 | 1905篇 |
2008年 | 3161篇 |
2007年 | 3125篇 |
2006年 | 2876篇 |
2005年 | 2581篇 |
2004年 | 2208篇 |
2003年 | 2057篇 |
2002年 | 1821篇 |
2001年 | 911篇 |
2000年 | 820篇 |
1999年 | 738篇 |
1998年 | 360篇 |
1997年 | 288篇 |
1996年 | 260篇 |
1995年 | 214篇 |
1994年 | 214篇 |
1993年 | 179篇 |
1992年 | 395篇 |
1991年 | 354篇 |
1990年 | 306篇 |
1989年 | 281篇 |
1988年 | 254篇 |
1987年 | 194篇 |
1986年 | 225篇 |
1985年 | 190篇 |
1984年 | 174篇 |
1983年 | 139篇 |
1982年 | 118篇 |
1981年 | 114篇 |
1980年 | 95篇 |
1979年 | 163篇 |
1978年 | 105篇 |
1977年 | 99篇 |
1976年 | 101篇 |
1975年 | 85篇 |
1973年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
11.
J. Oliveira-Santos R. Santos C. Moreira S. Abreu L. Lopes C. Agostinis-Sobrinho G. Stratton J. Mota 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2019,29(8):783-792
Background and aimsThe long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers indicative of low-grade inflammation, insulin resistance and lipid profiles in adolescence.Methods and resultsRetrospective school-based study with 415 Portuguese adolescents (220 girls), mean age of 14.08 ± 1.6 years old. Anthropometric data from birth to 6 years old was extracted from individual child health book records. Actual weight and height were measured and BMI calculated. Participants were classified at each time point as normal weight or overweight according to WHO reference values. Biomarkers were obtained from venous blood samples. Linear regressions were used to explore the associations between the biomarkers and early life anthropometric indicators. From 2 years onwards, BMI associated positively with the inflammatory score and HOMA-IR in adolescence. Children who were overweight/obese from 2 to 6 years of age presented significantly higher inflammatory score and HOMA-IR later in adolescence. TC/HDL ratio was also positively associated with BMI from the age of 5 years onwards. The associations between BMI and cardiometabolic outcomes remained positive in adolescence, with overweight adolescents presenting a higher inflammatory score, HOMA-IR and TC/HDL than normal weight adolescents.ConclusionA high BMI from an early age was consistently associated with worse inflammatory and lipid profiles and insulin resistance in adolescence. No associations were found between BW and the same studied outcomes. 相似文献
12.
Sissa Brito dos Santos Aurélia Bertholet-Thomas Marine Butin Laurence Dubourg Alain Fouilhoux Justine Bacchetta 《Archives de pédiatrie》2021,28(4):338-341
The main clinical features of tyrosinemia type 1 usually appear in the first months of life, including fever, diarrhea, vomiting, liver involvement, growth failure, and renal proximal tubulopathy with subsequent hypophosphatemic rickets. An early diagnosis is crucial in order to provide specific management and to prevent complications. Here, we report on two cases referred primarily to pediatric nephrologists for the diagnosis of “neonatal tubulopathy” and management of “X-linked hypophosphatemia (XLH),” respectively. Our aim is to emphasize that (1) even a mixed tubulopathy can reveal tyrosinemia, and (2) tyrosinemia is a classic differential diagnosis of XLH that should not be forgotten, especially in the era of the anti-FGF23 burosumab. 相似文献
13.
14.
15.
16.
Carlos Robles-Medranda Manuel Valero Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Miguel Soria-Alc var Haydee Alvarado-Escobar Hannah Pitanga-Lukashok 《World journal of gastrointestinal endoscopy》2020,12(1):23-32
BACKGROUND Accurate detection of gastric infection by Helicobacter pylori(H.pylori) and premalignant lesions are important for effective provision of treatment,preventing the development of gastric neoplasia.Optical enhancement systems with optical magnification improved the identification of mucosal superficial and vascular patterns in patients with dyspepsia.AIM To evaluate an optical enhancement system with high-definition magnification,for diagnosis of normal gastric mucosa,H.pylori-associated gastritis,and gastric atrophy.METHODS A cross-sectional,nonrandomized study from November 2015 to April 2016 performed in a single-tertiary academic center from Ecuador.Seventy-two consecutive patients with functional dyspepsia according to the Rome III criteria,were tested for H.pylori using a stool antigen test and were assigned to an Hp+group or an Hp-control group.Esophagogastroduodenoscopy with highdefinition optical magnification and digital chromoendoscopy was performed,and patients were classified into 4 groups,in accordance to the microvasculararchitecture pattern of the mucosa.Interobserver and intraobserver agreement among operators were calculated.RESULTS Of the 72 participants,35 were Hp+ and 37 were Hp-.Among 10 patients with normal mucosal histology in biopsy samples,90% had a Type I pattern of microvascular architecture by endoscopy.Among participants with type IIa and type IIb patterns,significantly more were Hp+ than Hp-(32 vs 8),and most(31 out of 40) had histological diagnoses of chronic active gastritis.Two of the three participants with a histological diagnosis of atrophy had a type III microvascular pattern.The type I pattern predicted normal mucosa,type IIa–IIb predicted H.pylori infection,and type III predicted atrophy with sensitivities of 90.0%,91.4%,and 66.7%,respectively.The intraobserver and interobserver agreements had kappa values of 0.91 and 0.89,respectively.CONCLUSION High-definition optical magnification with digital chromoendoscopy is useful for diagnosis of normal gastric mucosa and H.pylori-associated gastritis with high accuracy,but further studies are needed to determine whether endoscopic diagnosis of gastric atrophy is feasible. 相似文献
17.
18.
19.
Thaís dos Santos Fontes Pereira Carolina Cavalieri Gomes Peter A Brennan Felipe Paiva Fonseca Ricardo Santiago Gomez 《Journal of oral pathology & medicine》2019,48(1):3-9
Fibrous dysplasia is a non‐neoplastic developmental process that affects the craniofacial bones, characterized by painless enlargement as a result of bone substitution by abnormal fibrous tissue. Postzygotic somatic activating mutations in the GNAS1 gene cause fibrous dysplasia and have been extensively investigated, as well as being helpful in the differential diagnosis of the disease. Fibrous dysplasia may involve one (monostotic) or multiple bones (polyostotic), sporadically or in association with McCune‐Albright syndrome, Jeffe‐Lichenstein syndrome, or Mazabreud syndrome. This review summarizes the current knowledge on fibrous dysplasia, emphasizing the value of integrating the understanding of its molecular pathogenesis with the clinical, radiological, and histopathological features. In addition, we address important aspects related to the differential diagnosis and patient management. 相似文献
20.