全文获取类型
收费全文 | 1730篇 |
免费 | 116篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 71篇 |
妇产科学 | 84篇 |
基础医学 | 179篇 |
口腔科学 | 63篇 |
临床医学 | 171篇 |
内科学 | 382篇 |
皮肤病学 | 17篇 |
神经病学 | 96篇 |
特种医学 | 23篇 |
外科学 | 315篇 |
综合类 | 35篇 |
预防医学 | 67篇 |
眼科学 | 67篇 |
药学 | 114篇 |
中国医学 | 6篇 |
肿瘤学 | 151篇 |
出版年
2024年 | 2篇 |
2023年 | 9篇 |
2022年 | 16篇 |
2021年 | 35篇 |
2020年 | 23篇 |
2019年 | 40篇 |
2018年 | 44篇 |
2017年 | 31篇 |
2016年 | 38篇 |
2015年 | 52篇 |
2014年 | 52篇 |
2013年 | 75篇 |
2012年 | 103篇 |
2011年 | 133篇 |
2010年 | 90篇 |
2009年 | 76篇 |
2008年 | 117篇 |
2007年 | 91篇 |
2006年 | 90篇 |
2005年 | 114篇 |
2004年 | 101篇 |
2003年 | 87篇 |
2002年 | 72篇 |
2001年 | 55篇 |
2000年 | 59篇 |
1999年 | 46篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 21篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 21篇 |
1990年 | 24篇 |
1989年 | 22篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1970年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有1865条查询结果,搜索用时 15 毫秒
31.
32.
33.
Chi‐Yuan Chen Shih‐Hwa Chiou Chih‐Yang Huang Chia‐Ing Jan Shu‐Chun Lin Wen‐Yuan Hu Shiu‐Huey Chou Chung‐Ji Liu Jeng‐Fan Lo 《The Journal of pathology》2009,219(3):347-355
Human tumourous imaginal disc (Tid1), a human homologue of the Drosophila tumour suppressor protein Tid56, is involved in multiple intracellular signalling pathways such as apoptosis, cell proliferation, and cell survival. Here, we investigated the anti‐tumourigenic activity of Tid1 in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. Firstly, the clinical association between Tid1 expression and progression of HNSCC was explored. It was found that expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC patient tumour tissue. Secondly, ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage‐independent growth, and xenotransplantation tumourigenicity. Thirdly, we showed that overexpression of Tid1 attenuated EGFR activity and blocked the activation of AKT in HNSCC cells, which are known to be involved in the regulation of survival in HNSCC cells. On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression. Together, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
34.
35.
Toong Long Jeng Yi Chen Chiang Chia Chi Lai Ting Chen Liao Su Yue Lin Tzu Che Lin Jih Min Sung 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2015,23(3):399
Several studies have reported the therapeutic use of caffeoylquinic acid (CQA) derivatives in the management of hyperglycemia. This study used a simulated in vitro gastrointestinal digestion model to assess the inhibitory effects of CQA derivatives-rich sweet potato leaf extract (SPLE) and a commercially produced green coffee bean extract (GCBE), each with total polyphenols contents of 452 mg g−1 and 278 mg g−1, respectively, against starch digestion. The changes in the amounts of total polyphenols and total CQA derivatives during in vitro gastrointestinal digestion were also examined. The results indicated that both extracts contained substantial levels of CQA derivatives (136 mg g−1 and 83.5 mg g−1 of extract for SPLE and GCBE, respectively). The amounts of total polyphenols and total CQA derivatives in 20 mg of SPLE and GCBE samples decreased from 9.04 mg to 0.58 mg and from 5.56 mg to 0.58 mg, and from 2.72 mg to 0.16 mg and from 1.67 mg to 0.10 mg, respectively, following in vitro gastrointestinal digestion and subsequent dialysis. When SPLE and GCBE were accompanied with starch for in vitro digestion test, they both exhibited inhibitory effect against starch digestion during simulated intestinal digestion, with estimated half maximal inhibitory concentration (IC50) values of 4.91 mg and 6.06 mg polyphenols, respectively. The amount of glucose permeated through dialysis membrane also decreased significantly in comparison with the extract-negative control. Thus, both SPLE and GCBE were capable of modulating the release of glucose from starch digestion in simulated intestinal tract. The observed inhibitory effects against glucose release were presumably due in part to the presence of CQA derivatives in the tested extracts. The SPLE had higher inhibitory effect against in vitro starch digestion than the commercially prepared reference GCBE. Therefore, the SPLE might be used to manage hyperglycemia over the long term. 相似文献
36.
Hydroxychloroquine may be associated with reduced risk of coronary artery diseases in patients with rheumatoid arthritis: A nationwide population‐based cohort study 下载免费PDF全文
37.
Chu Yu-Ju Jeng Wen-Juei Pan Mei-Hung Hu Hui-Han Luo Wen-Sheng Su Chien-Yu Chiang Chen-Tse Jen Chin-Lan Chen Chien-Jen Yang Hwai-I 《Journal of gastroenterology》2022,57(6):423-432
Journal of Gastroenterology - In chronic hepatitis B virus (HBV) infection, earlier seroclearance of hepatitis B e antigen (HBeAg) is associated with more favorable outcomes. Soluble programmed... 相似文献
38.
BACKGROUND/AIMS: Early detection of post-surgical infection is important to decrease mortality in patients after operation. Both C-reactive protein test and gallium-67 scan (gallium scan) are sensitive examinations in the detection of infection. In this study, we compared the diagnostic accuracy of the two modalities in the detection of infection after abdominal surgery. METHODOLOGY: Forty-six patients undergoing abdominal surgery were enrolled in this study. All patients received blood examination for C-reactive protein test and were referred to our department for gallium scan because of unknown fever after surgery. RESULTS: Of the 46 patients with abdominal surgery, 22 (47.8%) were diagnosed to have infection including 6 intra-abdominal abscesses, 8 wound infection and 8 with both intra-abdominal abscesses and wound infection. To achieve better diagnostic results, C-reactive protein value of 2.8 mg/dL was chosen as cut-off value. The diagnostic sensitivities for both gallium scan and C-reactive protein test were 100%. The diagnostic specificity of gallium scan was superior to C-reactive protein test (83.3% vs. 54.2%). The overall diagnostic accuracy of gallium scan and C-reactive protein test were 92.6% and 76%, respectively. CONCLUSIONS: Both C-reactive protein test and gallium scan have good sensitivity in the detection of infection after abdominal surgery. Gallium scan has better diagnostic specificity than the C-reactive protein test. 相似文献
39.
40.
Interferon-alpha reduces insulin resistance and beta-cell secretion in responders among patients with chronic hepatitis B and C 总被引:3,自引:0,他引:3
Tai TY Lu JY Chen CL Lai MY Chen PJ Kao JH Lee CZ Lee HS Chuang LM Jeng YM 《The Journal of endocrinology》2003,178(3):457-465
This study aimed at elucidating the effects of interferon (IFN)-alpha on glucose metabolism in patients with chronic hepatitis B and C infections. Twenty-eight biopsy-proven patients with chronic hepatitis B (ten cases) and hepatitis C (18 cases) were given IFN-alpha for a total of 24 weeks. The patients received a 75 g oral glucose tolerance test (OGTT), glucagon stimulation test, tests for type 1 diabetes-related autoantibodies and an insulin suppression test before and after IFN-alpha therapy. Ten of the 28 patients responded to IFN-alpha therapy. Steady-state plasma glucose of the insulin suppression test decreased significantly in responders (13.32+/-1.48 (S.E.M.) vs 11.33+/-1.19 mmol/l, P=0.0501) but not in non-responders (12.29+/-1.24 vs 11.11+/-0.99 mmol/l, P=0.2110) immediately after completion of IFN-alpha treatment. In the oral glucose tolerance test, no significant difference was observed in plasma glucose in either responders (10.17+/-0.23 vs 10.03+/-0.22 mmol/l) or non-responders (10.11+/-0.22 vs 9.97+/-0.21 mmol/l) 3 Months after completion of IFN-alpha treatment. However, significant differences were noted in C-peptide in both responders (2.90+/-0.13 vs 2.20+/-0.09 nmol/l, P=0.0040) and non-responders (2.45+/-0.11 vs 2.22+/-0.08 nmol/l, P=0.0287) before vs after treatment. The changes of C-peptide in an OGTT between responders and non-responders were also significantly different (P=0.0028), with responders reporting a greater reduction in C-peptide. No case developed autoantibodies during the treatment. In patients who were successfully treated with IFN-alpha, insulin sensitivity improved and their plasma glucose stayed at the same level without secreting as much insulin from islet beta-cells. 相似文献