全文获取类型
收费全文 | 53531篇 |
免费 | 3132篇 |
国内免费 | 256篇 |
专业分类
耳鼻咽喉 | 649篇 |
儿科学 | 1207篇 |
妇产科学 | 1255篇 |
基础医学 | 7607篇 |
口腔科学 | 1522篇 |
临床医学 | 5752篇 |
内科学 | 11685篇 |
皮肤病学 | 849篇 |
神经病学 | 5213篇 |
特种医学 | 1874篇 |
外科学 | 6566篇 |
综合类 | 345篇 |
一般理论 | 44篇 |
预防医学 | 3813篇 |
眼科学 | 819篇 |
药学 | 3649篇 |
1篇 | |
中国医学 | 66篇 |
肿瘤学 | 4003篇 |
出版年
2023年 | 338篇 |
2022年 | 697篇 |
2021年 | 1247篇 |
2020年 | 795篇 |
2019年 | 1038篇 |
2018年 | 1256篇 |
2017年 | 1127篇 |
2016年 | 1320篇 |
2015年 | 1388篇 |
2014年 | 1832篇 |
2013年 | 2636篇 |
2012年 | 4003篇 |
2011年 | 4209篇 |
2010年 | 2509篇 |
2009年 | 2234篇 |
2008年 | 3456篇 |
2007年 | 3749篇 |
2006年 | 3345篇 |
2005年 | 3398篇 |
2004年 | 3119篇 |
2003年 | 2903篇 |
2002年 | 2659篇 |
2001年 | 444篇 |
2000年 | 360篇 |
1999年 | 508篇 |
1998年 | 571篇 |
1997年 | 471篇 |
1996年 | 412篇 |
1995年 | 356篇 |
1994年 | 312篇 |
1993年 | 316篇 |
1992年 | 253篇 |
1991年 | 238篇 |
1990年 | 226篇 |
1989年 | 228篇 |
1988年 | 207篇 |
1987年 | 178篇 |
1986年 | 183篇 |
1985年 | 223篇 |
1984年 | 192篇 |
1983年 | 173篇 |
1982年 | 203篇 |
1981年 | 166篇 |
1980年 | 144篇 |
1979年 | 126篇 |
1978年 | 131篇 |
1977年 | 141篇 |
1976年 | 95篇 |
1975年 | 113篇 |
1974年 | 95篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
52.
Helena Malmgren Karl-Henrik Gustavson Jan Wahlstrm Ingrid Arpi-Henriksson Jurgen Bensch Ulf Pettersson Niklas Dahl 《American journal of medical genetics. Part A》1992,44(6):830-833
Twenty-two members of 18 families with autism have been examined for the presence of mutations and abnormal methylation in the FMR-1 region at Xq27.3. All patients fulfilled diagnostic criteria of infantile autism. A characteristic pattern of insertion and methylation were detected after Southern blot analysis in 7 autistic individuals expressing the fragile site at Xq27.3. Normal DNA patterns were observed in 15 autistic boys cytogenetically negative for the fragile site. The results indicate a lack of involvement of the FMR-1 region in infantile autists negative for fragile X expression. © 1992 Wiley-Liss, Inc. 相似文献
53.
TomJ. Snijders Frank-Erik Leeuw UrsulaM.H. Klumpers L.Jaap Kappelle Jan Gijn 《Journal of neurology》1992,239(Z2):S1-S3
Oral session 1: General neurology 相似文献
54.
Jan Lycke Bo Svennerholm Anders Svenningsson Walter Muranyi Rolf M. Flügel Oluf Andersen 《Journal of neurology》1994,241(4):204-209
The role of human spumaretrovirus (HSRV) infections in the pathogenesis of multiple sclerosis (MS) was investigated with recombinant HSRV env-specific enzyme-linked immunosorbent assay. The presence of HSRV antibodies was determined in pairs of serum and cerebrospinal fluid (CSF) samples from 60 MS patients. In 7 of these patients serial serum and CSF samples were obtained in relation to the clinical activity of the disease during a period of 2 years. No increased antibody reactivity was demonstrable in the MS population compared with 14 aseptic meningitis patients, 50 blood donors and 16 healthy controls. Slightly elevated levels of antibodies were demonstrable in serum and/or CSF in 4 MS patients but also in 1 patient with aseptic meningitis, 1 blood donor and 1 child. No marked serum or CSF HSRV antibody fluctuation was observed in the MS patients followed longitudinally. Thus, this study does not support the involvement of HSRV in the pathogenesis of MS. 相似文献
55.
Hein Heidbüchel Domenico Corrado Allessandro Biffi Ellen Hoffmann Nicole Panhuyzen-Goedkoop Jan Hoogsteen Pietro Delise Per Ivar Hoff Antonio Pelliccia 《European journal of cardiovascular prevention and rehabilitation》2006,13(5):676-686
This consensus paper on behalf of the Study Group on Sports Cardiology of the European Society of Cardiology follows a previous one on guidelines for sports participation in competitive and recreational athletes with supraventricular arrhythmias and pacemakers. The question of imminent life-threatening arrhythmias is especially relevant when some form of ventricular rhythm disorder is documented, or when the patient is diagnosed to have inherited a pro-arrhythmogenic disorder. Frequent ventricular premature beats or nonsustained ventricular tachycardia may be a hallmark of underlying pathology and increased risk. Their finding should prompt a thorough cardiac evaluation, including both imaging modalities and electrophysiological techniques. This should allow distinguishing idiopathic rhythm disorders from underlying disease that carries a more ominous prognosis. Recommendations on sports participation in inherited arrhythmogenic conditions and asymptomatic gene carriers are also discussed: congenital and acquired long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy and other familial electrical disease of unknown origin. If an implantable cardioverter defibrillator is indicated, it is no substitute for the guidelines relating to the underlying pathology. Moreover, some particular recommendations for patients/athletes with an implantable cardioverter defibrillator are to be observed. 相似文献
56.
Elke Wezenberg Robert Jan Verkes Ge S F Ruigt Wouter Hulstijn Bernard G C Sabbe 《Neuropsychopharmacology》2007,32(6):1272-1283
Ampakines act as positive allosteric modulators of AMPA-type glutamate receptors and facilitate hippocampal long-term potentiation (LTP), a mechanism associated with memory storage and consolidation. The present study investigated the acute effects of farampator, 1-(benzofurazan-5-ylcarbonyl) piperidine, on memory and information processes in healthy elderly volunteers. A double-blind, placebo-controlled, randomized, cross-over study was performed in 16 healthy, elderly volunteers (eight male, eight female; mean age 66.1, SD 4.5 years). All subjects received farampator (500 mg) and placebo. Testing took place 1 h after drug intake, which was around Tmax for farampator. Subjects performed tasks assessing episodic memory (wordlist learning and picture memory), working and short-term memory (N-back, symbol recall) and motor learning (maze task, pursuit rotor). Information processing was assessed with a tangled lines task, the symbol digit substitution test (SDST) and the continuous trail making test (CTMT). Farampator (500 mg) unequivocally improved short-term memory but appeared to impair episodic memory. Furthermore, it tended to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs had significantly higher plasma levels of farampator than subjects without SEs. Additional analyses revealed that in the farampator condition the group without SEs showed a significantly superior memory performance relative to the group with SEs. The positive results on short-term memory and the favorable trends in the trail making test (CTMT) are interesting in view of the development of ampakines in the treatment of Alzheimer's disease and schizophrenia. 相似文献
57.
58.
Christopher G. Petr Ph.D. John Pierpont MSW 《The journal of behavioral health services & research》1992,19(2):195-206
The objectives of this study were to identify the strengths and weaknesses of Minnesota’s Comprehensive Children’s Mental Health Act of 1989 and its early implementation in Hennepin County, Minn. Data were collected from official documents and key informants relative to three implementation criteria: (1) community-based and family-centered values; (2) the range, coordination, and affordability of services; and (3) process, outcome, and consumer accountability. Findings suggest that the state law is a laudable, yet seriously limited, attempt to reform the system of care for children with emotional disorders. While the law is strong in its intent regarding community-based value, range, and coordination of services as well as process accountability, implementation has been hampered by weaker intent with respect to other criteria and by a lack of a comprehensive financing plan. Despite these limitations in the state law, Hennepin County has moved to use the law as leverage to improve the local system of care. Implications for reformers in other states center on the issues of state/county relationships, scope of initial efforts, choice of organizational structure, and the interplay of financing and accountability issues. 相似文献
59.
Nearly a billion dollars were made available to state health departments through federal grants in the spring of 2002 for public health emergency preparedness plans. Twenty-one states had already been participating for some years in The Robert Wood Johnson Foundation's Turning Point Initiative. This article illustrates how earlier practice and experience in developing cross-sector collaborations and institutionalizing a model of broad-based partnerships for public health decision making can increase effectiveness and efficiency in responding to a call for action around an emergency. 相似文献
60.
Jan McGregor Hepburn 《British Journal of Psychotherapy》1992,9(1):24-32
ABSTRACT. This paper is an attempt to think about a process and experience which is essentially before thinking in its origins; that is to say, the maternal experience of holding the baby in mind and the baby's experience of being held. I have looked at the issue subjectively and anecdotally, for which in the end I make no apology as I can see no other way to proceed, at least in the first instance; and I want to think about how this thinking applies to the practice of psychoanalytic psychotherapy. 相似文献