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101.
In a prospective, randomized, double-blind study, 49 patients underwent lumbar myelography using iotrol (24 patients) or metrizamide (25 patients). The diagnostic imaging adequacy of iotrol was comparable with that of metrizamide. After iotrol myelography, adverse reactions were fewer, less severe, and of shorter duration than were those following metrizamide myelography. Thirteen of 24 patients (54%) receiving iotrol reported some adverse reactions compared with 24 of 25 patients (96%) receiving metrizamide. Five moderate and one severe adverse reaction occurred in the group receiving iotrol. Fourteen moderate and eight severe adverse reactions occurred in the group receiving metrizamide. Thirty-eight patients underwent electroencephalography both before and after myelography (19 iotrol and 19 metrizamide). None of the EEGs obtained after iotrol myelography changed from baseline, while seven of the EEGs obtained after metrizamide myelography showed changes from baseline. Iotrol was judged superior to metrizamide as a contrast medium in this patient population. 相似文献
102.
103.
Raoul JL; Bourguet P; Bretagne JF; Duvauferrier R; Coornaert S; Darnault P; Ramee A; Herry JY; Gastard J 《Radiology》1988,168(2):541-545
Biodistribution of iodine-131-labeled Lipiodol Ultra-Fluide (I-131 LUF) injected into the hepatic artery was studied scintigraphically in 47 patients with hepatocellular carcinoma (n = 23), hepatic metastases (n = 14), or normal livers (n = 10). The investigation was extremely well tolerated. I-131 LUF concentrated mainly in the liver (L) and the lungs (l), with L/L + l activity ratios greater than 75% for all three groups of patients. I-131 LUF distribution was homogeneous in normal livers and heterogeneous in cirrhotic livers. I-131 LUF concentrated in the tumor with a tumorous (T) to nontumorous (NT) activity ratio (T/NT) of 4.3 +/- 3.6 for hepatocellular carcinoma and 2.4 +/- 0.7 for hepatic metastases. The effective half-life of I-131 LUF is more than 4.5 days for the three groups. It was eliminated mainly through the urine. Clearance from tumor is slower than from normal liver, as shown by the increase in T/NT at day 18. Biodistribution did not change in patients who had a second injection, which indicates that there is no saturation phenomenon. The results of this study suggest that LUF may be considered as a potential carrier vehicle for therapeutic agents. 相似文献
104.
105.
Diabetes, oxidative stress, and platelet activation 总被引:1,自引:0,他引:1
106.
The nuclear concentration of kin17, a mouse protein that binds to curved DNA, increases during cell proliferation and after UV irradiation 总被引:2,自引:1,他引:1
Kannouche P; Pinon-Lataillade G; Tissier A; Chevalier-Lagente O; Sarasin A; Mezzina M; Angulo JF 《Carcinogenesis》1998,19(5):781-789
UV-irradiation induces, in mammalian cells, the expression of a set of
genes known as the 'UV-response', which may be reminiscent of the bacterial
response, called SOS system. The multifunctional protein RecA controls the
expression of the SOS genes. We report the expression profile of a mouse
gene conserved among mammals, called Kin17, that codes a DNA-binding
protein of undetermined biochemical activity and which shares epitopes with
the bacterial RecA protein. We demonstrate that the level of Kin17 RNA was
5-fold higher in mid-S phase of serum- stimulated BALB/c 3T3 fibroblasts
than in quiescent cells. Cells in S- phase displayed a high level of kin17
protein with a marked nuclear localisation. The maximal level of Kin17 RNA
was observed 18 h after serum stimulation, indicating that Kin17 gene is a
new member of the late growth-related genes. The accumulation of kin17
protein during cell proliferation follows the increase in Kin17 RNA and
correlates with DNA synthesis, which suggests a possible role of kin17
protein in a transaction related to DNA-replication. In quiescent
fibroblasts, a 3- fold increase in Kin17 RNA was seen 13 h after UV
irradiation. In parallel, kin17 protein accumulated in the nucleus, which
suggests that it might be required after the stress produced by UV
irradiation.
相似文献
107.
108.
109.
Patients with the syndrome of chronic daily headache often report migrainous symptoms and consequently are diagnosed as having a primary headache syndrome. We report two cases of idiopathic intracranial hypertension causing chronic daily headache with migrainous features in the absence of associated papilledema. 相似文献
110.
The efficacy of concurrent radiochemotherapy should be evaluated in term of therapeutic ratio. The aims of treatment are increasing local control and possibly overall survival. Acute toxicity should be reported using the WHO recommendations, while late toxicity is reported using the scales recommended by the EORTC and RTOC Radiotherapy Groups. Moreover, functional, esthetic and quality of life considerations should be introduced. The application of these treatments needs a well-designed multidisciplinary staff. 相似文献