全文获取类型
收费全文 | 1835篇 |
免费 | 109篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 43篇 |
妇产科学 | 55篇 |
基础医学 | 229篇 |
口腔科学 | 55篇 |
临床医学 | 159篇 |
内科学 | 540篇 |
皮肤病学 | 63篇 |
神经病学 | 146篇 |
特种医学 | 31篇 |
外科学 | 170篇 |
综合类 | 5篇 |
一般理论 | 3篇 |
预防医学 | 206篇 |
眼科学 | 22篇 |
药学 | 96篇 |
中国医学 | 9篇 |
肿瘤学 | 123篇 |
出版年
2023年 | 19篇 |
2022年 | 29篇 |
2021年 | 90篇 |
2020年 | 46篇 |
2019年 | 74篇 |
2018年 | 71篇 |
2017年 | 51篇 |
2016年 | 36篇 |
2015年 | 73篇 |
2014年 | 69篇 |
2013年 | 109篇 |
2012年 | 165篇 |
2011年 | 176篇 |
2010年 | 91篇 |
2009年 | 95篇 |
2008年 | 137篇 |
2007年 | 110篇 |
2006年 | 112篇 |
2005年 | 89篇 |
2004年 | 96篇 |
2003年 | 67篇 |
2002年 | 59篇 |
2001年 | 11篇 |
2000年 | 8篇 |
1999年 | 12篇 |
1998年 | 14篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有1956条查询结果,搜索用时 46 毫秒
61.
Marina Pérez Redondo Sara Alcántara Carmona Inmaculada Fernández Simón Héctor Villanueva Fernández Alfonso Ortega López Cándido Pardo Rey Jorge Duerto Álvarez Inés Lipperheide Vallhonrat Manuel González Romero Daniel Ballesteros Ortega Francisco del Río Gallegos Juan José Rubio Muñoz 《Clinical transplantation》2020,34(8):e13899
Normothermic regional perfusion (NRP) in controlled donation after circulatory death is becoming a popular method due to the favorable results of the grafts procured under this technique. This procedure requires experience, and, sometimes, the availability of extracorporeal membrane oxygenation (ECMO) machines to implement NRP is limited to tertiary hospitals. In order to provide support with NRP in controlled donation after circulatory death across the different hospitals of the Autonomous Community of Madrid, a mobile NRP team was created. In the first 18 months since its creation, the mobile NRP team participated in 33 procurements across nine different hospitals, representing 72% of all controlled donations after circulatory death in the Autonomous Community of Madrid. NRP was successfully performed in 29 (88%) cases, with a mean duration of 69 ± 27 minutes. A total of 39 kidneys, 12 livers, and 5 bilateral lungs were recovered and transplanted. None of the livers were discarded due to an elevation in transaminases during NRP. A mobile NRP team is a feasible option and, in our series, aided in the optimization and recovery of organs from donors after controlled circulatory death in centers where ECMO technology was not available. 相似文献
62.
63.
González de Requena D Gallego O de Mendoza C Corral A Jiménez-Nácher I Soriano V 《AIDS research and human retroviruses》2003,19(6):457-459
Virological failure under protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of resistance mutations. The role of low indinavir (IDV) plasma levels in treatment failure was assessed in 46 subjects experiencing early virological failure to a first-line IDV-containing triple combination. Overall, 69% of patients showed subtherapeutic IDV plasma levels (it was not detected at all in 75% of them). Subjects with detectable but suboptimal IDV levels developed more IDV resistance mutations. Thus, drug monitoring may be useful to assess treatment adherence and risk of drug resistance in early virological failures. This information may be crucial for choosing the most appropriate rescue intervention. 相似文献
64.
Baltazar JC Ancheta CA Aban IB Fernando RE Baquilod MM 《Diabetes research and clinical practice》2004,64(2):107-115
Recognizing the problem posed by diabetes mellitus, the National Diabetes Commission was created by Republic Act 8191 in 1996. The Commission identified the need for a Second National Diabetes Survey to have an updated estimate of the magnitude of the disease in the country and to have the needed information for developing a diabetes prevention and control program. This paper reports the prevalence of diabetes mellitus and impaired glucose tolerance (IGT) in adults and the factors associated with the prevalence of these conditions. A cross-sectional population-based study assessed the occurrence of diabetes and impaired glucose tolerance among a random sample of 7044 adults, aged 20-65 years who were residents of urban and rural areas in Luzon. Blood glucose level was measured by OGTT using the current WHO criteria. The crude diabetes prevalence of 5.1% represented a 54% increase over the figure (3.3%) for a similar population in Luzon in 1982. An increase was also noted in the magnitude of IGT which almost doubled from 4.1% in 1982 to 8.1% in the present survey. Only one in three diabetics reported that they had diabetes. The frequency of diabetes and IGT in urban and rural areas were about the same, although a substantial increase from the earlier survey was noted in rural areas. Women registered a higher prevalence for both conditions than men. Aside from age and gender, the other correlates of diabetes mellitus were hypertension, family history of diabetes, WHR, BMI, and physical inactivity. IGT had similar correlates as diabetes except physical inactivity. The present findings which are consistent with those of other studies underscore the role of lifestyle behaviors in diabetes and should be the target of intervention to prevent further increase in disease frequency. 相似文献
65.
M. Inmaculada Poveda García M. Dolores del Pino y Pino Raquel Alarcón Rodriguez Cristian Rodelo-Haad Tesifón Parrón Carreño 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2019,39(1):67-72
Introduction
We aimed to assess the effectiveness of ambulatory blood pressure monitoring (ABPM) and subclinical target organ damage parameters for diagnosis of resistant hypertension (RH).Methods
We assessed demographic and anthropometric variables, the incidence of cardiovascular events and subclinical target organ damage (n = 112). We also studied the relationship between these variables and the ABPM results.Results
Of the 112 patients referred from primary care with a diagnosis of RH, 69 (61.6%) were confirmed by ABPM. We found statistically significant differences (P < .001) between patients with RH and pseudo-resistant hypertension in the appearance of subclinical target organ damage. A percentage of 84 of the patients had microalbuminuria: 66.25 ± 30.7 mg/dl); 44.9% had stage 3 chronic kidney disease: the average glomerular filtration was 59 ml/min/1.73 m2; and 56.5% had left ventricular hypertrophy on echocardiography. Fundoscopy revealed that 64% of the patients had hypertensive retinopathy. Three variables were associated with an increased HR risk: microalbuminuria, hypertensive retinopathy and left ventricular hypertrophy (OR 5.7, 6.2 and 11.2, respectively).Conclusions
This study shows that the systematic testing for target organ damage, particularly in terms of albuminuria, is a simple and inexpensive tool, with a high predictive value for RH (85%), which could be useful for prioritising patients who need ABPM. 相似文献66.
Maria Foraster Xavier Basaga?a Inmaculada Aguilera Marcela Rivera David Agis Laura Bouso Alexandre Deltell Jaume Marrugat Rafel Ramos Jordi Sunyer Joan Vila Roberto Elosua Nino Künzli 《Environmental health perspectives》2014,122(4):404-411
Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure to traffic noise and biased due to inappropriate control for use of BP-lowering medications.Objectives: We evaluated the associations of long-term traffic-related air pollution with BP and prevalent hypertension, adjusting for transportation noise and assessing different methodologies to control for BP-lowering medications.Methods: We measured systolic (SBP) and diastolic BP (DBP) at baseline (years 2003–2005) in 3,700 participants, 35–83 years of age, from a population-based cohort in Spain. We estimated home outdoor annual average concentrations of nitrogen dioxide (NO2) with a land-use regression model. We used multivariate linear and logistic regression.Results: A 10-μg/m3 increase in NO2 levels was associated with 1.34 mmHg (95% CI: 0.14, 2.55) higher SBP in nonmedicated individuals, after adjusting for transportation noise. Results were similar in the entire population after adjusting for medication, as commonly done, but weaker when other methods were used to account for medication use. For example, when 10 mmHg were added to the measured SBP levels of medicated participants, the association was β = 0.78 (95% CI: –0.43, 2.00). NO2 was not associated with hypertension. Associations of NO2 with SBP and DBP were stronger in participants with cardiovascular disease, and the association with SBP was stronger in those exposed to high traffic density and traffic noise levels ≥ 55 dB(A).Conclusions: We observed a positive association between long-term exposure to NO2 and SBP, after adjustment for transportation noise, which was sensitive to the methodology used to account for medication.Citation: Foraster M, Basagaña X, Aguilera I, Rivera M, Agis D, Bouso L, Deltell A, Marrugat J, Ramos R, Sunyer J, Vila J, Elosua R, Künzli N. 2014. Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population–based cohort in Spain (the REGICOR study). Environ Health Perspect 122:404–411; http://dx.doi.org/10.1289/ehp.1306497 相似文献
67.
68.
Victoria Pueyo Inés García-Ormaechea Inmaculada González Concepción Ferrer Guillermo de la Mata María Duplá Pedro Orós Eva Andres 《Early human development》2014
Background
Visual cognitive functions of preverbal infants are evaluated by means of a behavioral assessment. Parents or primary caregivers may be appropriate to certify the acquisition of certain abilities.Aims
To develop the PreViAs (Preverbal Visual Assessment) questionnaire to assess visual behavior of infants under 24 months of age and to assess the normative outcomes for each item at each age.Study design
The process was divided into three phases: scale development (items and domains generation), pilot testing, and exploratory analysis.Results
The final version of the PreViAs questionnaire consisted of 30 items, each related to one or more of four domains (visual attention, visual communication, visual–motor coordination, and visual processing). For the exploratory analysis, 298 children (159 boys and 139 girls) were recruited. Their ages ranged from 0.1 to 24 months (mean, 11.2 months). Internal consistency of the questionnaire was high for all domains (Cronbach's α coefficients of 0.85–0.94).Conclusions
The PreViAs questionnaire is a useful scale for assessing visual cognitive abilities of infants under 24 months of age. It is easy and feasible to complete by primary caregivers. 相似文献69.
Manuel Toledano Fátima S. Aguilera Salvatore Sauro Inmaculada Cabello Estrella Osorio Raquel Osorio 《Dental materials》2014
Objectives
The purpose of this study was to evaluate if mechanical loading promotes bioactivity at the resin interface after bonding with three different adhesive approaches.Methods
Dentin surfaces were subjected to three different treatments: demineralisation by (1) 37% phosphoric acid (PA) followed by application of an etch-and-rinse dentin adhesive Single Bond (SB) (PA + SB), (2) by 0.5 M ethylenediaminetetraacetic acid (EDTA) followed by SB (EDTA + SB), (3) application of a self-etch dentin adhesive: Clearfil SE Bond (SEB). Bonded interfaces were stored in simulated body fluid during 24 h or 3 w. One half of each tooth was submitted to mechanical loading. Remineralisation of the bonded interfaces was assessed by AFM imaging/nano-indentation, Raman spectroscopy/cluster analysis, dye assisted confocal microscopy evaluation (CLSM) and Masson's trichrome staining.Results
Loading cycling for 3 w promoted an increase of mechanical properties at the resin–dentin interface. Cluster analysis demonstrated an augmentation of the mineral–matrix ratio in SB-loaded specimens. CLSM showed an absent micropermeability and nanoleakage after loading EDTA + SB and SEB specimens. Trichrome staining reflected a narrow demineralised dentin matrix after loading, almost not observable in EDTA + SB and SEB.Significance
In vitro mechanical loading promoted mineralization in the resin–dentin interfaces, at 24 h and 3 w of storage. 相似文献70.
Esther Carramolino-Cuéllar Inmaculada Tomás Yolanda Jiménez-Soriano 《Medicina oral, patología oral y cirugía bucal》2014,19(3):e289-e294
The components of the human body are closely interdependent; as a result, disease conditions in some organs or components can influence the development of disease in other body locations. The effect of oral health upon health in general has been investigated for decades by many epidemiological studies. In this context, there appears to be a clear relationship between deficient oral hygiene and different systemic disorders such as cardiovascular disease and metabolic syndrome. The precise relationship between them is the subject of ongoing research, and a variety of theories have been proposed, though most of them postulate the mediation of an inflammatory response. This association between the oral cavity and disease in general requires further study, and health professionals should be made aware of the importance of adopting measures destined to promote correct oral health.
The present study conducts a Medline search with the purpose of offering an update on the relationship between oral diseases and cardiovascular diseases, together with an evaluation of the bidirectional relationship between metabolic syndrome and periodontal disease.
Most authors effectively describe a moderate association between the oral cavity and cardiovascular diseases, though they also report a lack of scientific evidence that oral alterations constitute an independent cause of cardiovascular diseases, or that their adequate treatment can contribute to prevent such diseases.
In the case of metabolic syndrome, obesity and particularly diabetes mellitus may be associated to an increased susceptibility to periodontitis. However, it is not clear whether periodontal treatment is able to improve the systemic conditions of these patients.
Key words:Cardiovascular diseases, periodontitis, metabolic syndrome, obesity, diabetes mellitus. 相似文献