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排序方式: 共有598条查询结果,搜索用时 15 毫秒
591.
Janssen I Powell LH Jasielec MS Matthews KA Hollenberg SM Sutton-Tyrrell K Everson-Rose SA 《Annals of behavioral medicine》2012,43(1):39-49
Background
Black women experience higher rates of cardiovascular disease (CVD) than white women, though evidence for racial differences in subclinical CVD is mixed. Few studies have examined multiple roles (number, perceived stress, and/or reward) in relation to subclinical CVD, or whether those effects differ by race. 相似文献592.
593.
Aims/hypothesis The aim of this study was to investigate the association of glucose levels and variability of glucose, assessed by continuous
glucose monitoring, with mood in type 1 diabetic patients.
Materials and methods Thirty-six type 1 diabetic patients (77.8% male, age: 31.1 ± 10.0 years; disease duration: 14.7 ± 7.1 years, BMI: 26.7 ± 5.1 kg/m2, HbA1c 8.4 ±1.8%, 27.8% with continuous subcutaneous insulin infusion [CSII] therapy) used a continuous glucose monitoring system
for 48.8 h. During this time the patients rated their current mood states 14.6 times on average, using the University of Wales
Institute of Science and Technology Mood Adjective Checklist and hand-held computers.
Results Sensor performance was satisfactory, with a mean absolute difference from reference laboratory glucose measurement of 13.7%.
Current glucose values were significantly associated with ratings of ‘tension’ (z = 2.40), ‘hedonic tone’ (z = −2.63) and ‘energetic arousal’ (z = −2.09). ‘Anger’ (z = 1.64) was not significantly associated with glucose values. The glucose AUC during the 60 min prior to the mood rating
showed similar associations. The two parameters of glucose variability—coefficient of variation and absolute glucose change
during the 60 min prior to the mood ratings—did not show any significant association with the mood ratings. The magnitude
of association was significantly higher for glucose level than for glucose variability in the scales ‘tension’ and ‘hedonic
tone’.
Conclusions/interpretation High glucose values had a negative impact on mood; positive mood ratings decreased, whereas negative mood ratings increased.
The association between mood and glucose variability seemed to be less important than that between glucose level and mood. 相似文献
594.
Berglund G Petersson LM Eriksson KC Wallenius I Roshanai A Nordin KM Sjödén PO Häggman M 《Acta oncologica (Stockholm, Sweden)》2007,46(1):83-89
The aim of this study was to evaluate the effect of psychosocial rehabilitation on newly diagnosed prostate cancer patients. The “Between Men” programme consisted of seven weekly sessions of physical training (Phys) alone, information (Info) alone or physical training plus information (PhysInfo). After diagnoses, patients (n =211) were consecutively included, stratified and randomised to one of four groups: Phys, Info, PhysInfo or standard care control (C). A nurse specialised in urology, an urologist and a physiotherapist performed the interventions. Patients were followed up during one year with mailed standardised questionnaires. It could not be assumed that the “Between Men” programme had any effect on patients' anxiety and depression (HADS). Health-related quality of life (HRQOL) was associated with stage of disease but not with psychosocial intervention. Thus, Physical Function (PF), Role Function (RF) and Fatigue (FA) were inferior among patients with, than without, metastases of prostate cancer both at baseline and at the 12-month follow-up. This randomized study did not demonstrate any significant effect of psychosocial rehabilitation among prostate cancer patients. Considering the low rate (1/2), of included/eligible patients a less complicated design (intervention versus control) would have been preferred in order to increase power. 相似文献
595.
Laila Terzic Angela Voegtle Amr Farahat Nanna Hartong Imke Galazky Slawomir J. Nasuto Adriano de Oliveira Andrade Robert T. Knight Richard B. Ivry Jürgen Voges Lars Buentjen Catherine M. SweeneyReed 《Human brain mapping》2022,43(15):4791
The network of brain structures engaged in motor sequence learning comprises the same structures as those involved in tremor, including basal ganglia, cerebellum, thalamus, and motor cortex. Deep brain stimulation (DBS) of the ventrointermediate nucleus of the thalamus (VIM) reduces tremor, but the effects on motor sequence learning are unknown. We investigated whether VIM stimulation has an impact on motor sequence learning and hypothesized that stimulation effects depend on the laterality of electrode location. Twenty patients (age: 38–81 years; 12 female) with VIM electrodes implanted to treat essential tremor (ET) successfully performed a serial reaction time task, varying whether the stimuli followed a repeating pattern or were selected at random, during which VIM‐DBS was either on or off. Analyses of variance were applied to evaluate motor sequence learning performance according to reaction times (RTs) and accuracy. An interaction was observed between whether the sequence was repeated or random and whether VIM‐DBS was on or off (F[1,18] = 7.89, p = .012). Motor sequence learning, reflected by reduced RTs for repeated sequences, was greater with DBS on than off (T[19] = 2.34, p = .031). Stimulation location correlated with the degree of motor learning, with greater motor learning when stimulation targeted the lateral VIM (n = 23, ρ = 0.46; p = .027). These results demonstrate the beneficial effects of VIM‐DBS on motor sequence learning in ET patients, particularly with lateral VIM electrode location, and provide evidence for a role for the VIM in motor sequence learning. 相似文献
596.
Martin Regensburger Laura Krumm Manuel Alexander Schmidt Andreas Schmid Imke Tabea Spatz Dominique Cornelius Marterstock Christoph Kopp Zacharias Kohl Arnd Doerfler Thomas Karrasch Beate Winner Jürgen Winkler 《Nutrients》2022,14(22)
Background: Pathogenic variants in SPG11 cause the most common autosomal recessive complicated hereditary spastic paraplegia. Besides the prototypical combination of spastic paraplegia with a thin corpus callosum, obesity has increasingly been reported in this multisystem neurodegenerative disease. However, a detailed analysis of the metabolic state is lacking. Methods: In order to characterize metabolic alterations, a cross-sectional analysis was performed comparing SPG11 patients (n = 16) and matched healthy controls (n = 16). We quantified anthropometric parameters, body composition as determined by bioimpedance spectroscopy, and serum metabolic biomarkers, and we measured hypothalamic volume by high-field MRI. Results: Compared to healthy controls, SPG11 patients exhibited profound changes in body composition, characterized by increased fat tissue index, decreased lean tissue index, and decreased muscle mass. The presence of lymphedema correlated with increased extracellular fluid. The serum levels of the adipokines leptin, resistin, and progranulin were significantly altered in SPG11 while adiponectin and C1q/TNF-related protein 3 (CTRP-3) were unchanged. MRI volumetry revealed a decreased hypothalamic volume in SPG11 patients. Conclusions: Body composition, adipokine levels, and hypothalamic volume are altered in SPG11. Our data indicate a link between obesity and hypothalamic neurodegeneration in SPG11 and imply that specific metabolic interventions may prevent obesity despite severely impaired mobility in SPG11. 相似文献
597.
598.
Jenny Stritzelberger Anna Gesmann Imke Fuhrmann Sebastian Brandner Tamara M. Welte Stefanie Balk Felix Eisenhut Arnd Dörfler Roland Coras Werner Adler Stefan Schwab Florian Putz Rainer Fietkau Luitpold Distel Hajo Hamer 《Epilepsia》2023,64(7):1853-1861