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101.
We present two cases of patients with a past history of alcoholabuse admitted to the Intensive Care Unit (ICU) for treatmentof respiratory problems, after multiple trauma and after sub-totalcolectomy, respectively. In both patients, features of alcoholwithdrawal were prominent after sedation had been discontinued.Both were treated successfully with an infusion of clonidine. 相似文献
102.
TM CHAN KW CHAN JWM LAWFON CY LO FK LI WK LO M IP IKP CHENG 《Nephrology (Carlton, Vic.)》1995,1(1):39-46
Summary: The clinical course and renal pathologic features of anti-neutrophil cytoplasm auto-antibody (ANCA)-associated renal disease were studied among Chinese patients from a single centre. Eight ANCA positive patients with acute renal impairment were studied, four of whom required dialysis shortly after presentation. Their mean age at presentation was 61.6 ± 4.2 years. Renal histology, obtained in seven patients, showed paucummune crescentic glomerulonephritis in five patients, interstitial nephritis in two patients, and small vessel vasculitis in one patient. Pulmonary baemorrhage was the other common disease manifestation, present in four of the eight patients, necessitating ventilatory support in three patients. Neurologic, cutaneous, and gastrointestinal involvement were also observed. Seven of the eight patients tested positive for pANCA and anti-myeloperoxidase, while cANCA was detected in one patient of the eight patients, six (75%) responded to therapy, consisting of prednisolone and cyclophosphamide in five patients, and antibacterial therapy alone in one patient, who had interstitial nephritis but no evidence of vasculitis. Two patients died from sepsis and severe debilitation one month after presentation. of the other six patients, five had significant improvement of renal function, while one became dialysis-dependent. the levels of ANCA and C-reactive protein remained normal, and disease reactivation was not observed during follow-up for 32.4 ± 6.1 months. Patient and renal survival rates at one year were 75% and 62.5%, respectively. It was concluded that the clinical and pathologic features of ANCA-associated renal disease in Chinese patients are, in general, similar to those described in Caucasians. Nevertheless, cANCA-positivity is distinctly uncommon. the demonstration of interstitial nephritis in two of the eight patients underlines the importance of renal biopsy for correct histologic diagnosis. Early institution of aggressive immunosuppression and supportive therapies are essential for the achievement of favourable outcome in patients with vasculitis. 相似文献
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Preimplantation diagnosis of non-deletion Duchenne muscular dystrophy (DMD) by linkage polymerase chain reaction analysis 总被引:6,自引:5,他引:6
The use of preimplantation diagnosis for sex determination and detection of
exon deletion means that unaffected babies can be born to parents suffering
from Duchenne muscular dystrophy (DMD). However, those who do not have exon
deletion should also be considered for further investigation. A new method,
known as linkage analysis, has been developed to diagnose the presence of
non-deletion DMD in preimplantation embryos. Linkage analysis uses
informative intragenic and flanking markers to track the chromosome bearing
the mutated gene. The present study reports the analysis of two polymorphic
sites, in blastomeres biopsied from embryos from a female carrier of DMD. A
single male embryo was obtained who had inherited alternate maternal
alleles to the woman's affected surviving son, and this embryo was
transferred.
相似文献
106.
107.
de Koning JP; Schelen AM; Dong F; van Buitenen C; Burgering BM; Bos JL; Lowenberg B; Touw IP 《Blood》1996,87(1):132-140