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301.
目的系统评价格列美脲与格列本脲治疗T2DM的疗效。方法计算机检索PubMed、万方等数据库从建库至2010年12月间的有关文献。按Cochrane系统评价的方法评价纳入研究的质量,使用Review Manager4.2软件进行荟萃分析。结果共纳入9个随机对照试验。结果显示:格列美脲在降低HbA1c[P=0.08,加权均数差(WMD)=-0.18,95%CI(-0.39,0.02)]、FPG[P=0.06,WM=-0.46,95%CI(-0.94,0.01)]、餐后血糖[P=O.73,WMD=-0.16,95%CI(-1.08,0.76)]、TC[P=0.22,WMD=-0.2,95%CI(-0.51,0.12)]和TG[P=0.06,WMD=-0.30,95%CI(-0.61,0.01)]方面与格列本脲无差异;在相同血糖水平下,格列美脲组FIns[P〈0.05,WMD=-0.83,95%CI(-1.21,0.45)]及餐后胰岛素[P〈0.05,WMD=-5.94,95%CI(-8.79,-3.10)]升高程度低于格列本脲组;低血糖发生率格列美脲组低于格列本脲组[P〈0.05,RR=0.66,95%CI(0.53,0.81)];在降低BMI方面格列美脲优于格列本脲[P=0.02,WMD=-1.49,95%CI(-2.7,-0.27)]。结论与格列本脲相比,格列美脲在降低血糖的同时,还能改善胰岛素抵抗及减轻体重,且低血糖发生率低,是安全有效的治疗T2DM的药物。 相似文献
302.
303.
AIM:To isolate,characterize and investigate the antifungal activity of the root bark of Psorospermum corymbiferum(Clusiaceae).METHODS:The finely ground root bark of Psorospermum corymbiferum was cold-extracted by percolation with 98% ethanol(5.0 L) for two weeks.The ethanol extract was macerated with n-hexane,chloroform,ethylacetate and methanol successively to give the respective solvent extracts.Fractionation of the extract was done using column chromatography on silica gel with cyclohexene:ethylacetate(1... 相似文献
304.
目的:探讨潜伏梅毒患者与临床相关因素的关系。方法:收集并整理573例梅毒患者中361例潜伏梅毒患者临床资料,对潜伏梅毒患者的年龄、性别、病期、就诊原因、血清学检验及诊治情况的特征进行统计学分析。结果:潜伏梅毒占梅毒发病率的63%,21~50岁性活跃期的人群发病率较高,老年人病程较长,均为各种筛查确诊而发现;潜伏梅毒RPR滴度较低,滴度在1∶8以下占96.12%,潜伏梅毒治疗血清阴转率偏低,多出现血清固定。结论:潜伏梅毒由于受到其隐蔽的临床特征的影响,难以早期发现,潜伏梅毒可以传播患者周围的人群,而且其潜在作用对患者健康危害较大。 相似文献
305.
306.
Rudofsky G Tsioga M Reismann P Leowardi C Kopf S Grafe IA Nawroth PP Isermann B 《European journal of medical research》2011,16(8):375-380
Background
Postoperative hyperthyroidism occurs in approximately one third of patients following parathyroidectomy due to primary hyperparathyroidism (PHP), but has only rarely been described in secondary hyperparathyroidism (SHP). The frequency, course, and laboratory markers of postoperative hyperthyroidism in SHP remain unknown. Our purpose was to evaluate the frequency and the clinical course of postoperative hypcrthyroidism following surgery of SHP and to determine the diagnostic value of thyroglobulin in this setting.Material and Methods
A total of 40 patients undergoing parathyroidectomy because of SHP were included in this study. Thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fl4), and thyroglobulin (Tg) were determined one day before and on day 1, 3, 5, 10, and 40 after surgery. At each of these visits patients were clinically evaluated for signs or symptoms of hyperthyroidism.Results
Biochemical evidence of hyperthyroidism was evident in 77% of patients postoperatively despite of preoperatively normal serum levels. TSH dropped from 1.18 ± 0.06mU/L to 0.15 ± 0.07mU/L (p = 0.0015). Free triiodothyronine (fT3) and fT4 levels increased from 2.86 ± 0.02ng/L and 10.32 ± 0.13ng/L, respectively, to their maximum of 4.83 ± 0.17ng/L and 19.35 ± 0.58ng/L, respectively. Thyroglobulin levels rose from 3.8 ± 0.8ng/mL to 111.8 ± 45.3ng/mL (p < 0.001). At day 40 all thyroid related laboratory values were within normal range. Correlation analysis of postoperative values revealed significant correlations for lowest TSH (r = -0.32; p = 0.038), and highest fT3 (r = 0.55; p < 0.001) and fT4 levels (r = 0.67; p < 0.001) with Tg.Conclusion
Transient hyperthyroidism is frequent after parathyroidectomy for SHP with Tg being a suitable marker. Awareness of this self-limiting disorder is important to avoid inappropriate and potentially harmful treatment. 相似文献307.
Background and purpose:
Ca2+-activated Cl− currents (ICl(Ca)) in arterial smooth muscle cells are inhibited by phosphorylation. The Ca2+-activated Cl− channel (ClCa) blocker niflumic acid (NFA) produces a paradoxical dual effect on ICl(Ca), causing stimulation or inhibition at potentials below or above 0 mV respectively. We tested whether the effects of NFA on ICl(Ca) were modulated by phosphorylation.Experimental approach:
ICl(Ca) was elicited with 500 nM free internal Ca2+ in rabbit pulmonary artery myocytes. The state of global phosphorylation was altered by cell dialysis with either 5 mM ATP or 0 mM ATP with or without an inhibitor of calmodulin-dependent protein kinase type II, KN-93 (10 µM).Key results:
Dephosphorylation enhanced the ability of 100 µM NFA to inhibit ICl(Ca). This effect was attributed to a large negative shift in the voltage-dependence of block, which was converted to stimulation at potentials <−50 mV, ∼70 mV more negative than cells dialysed with 5 mM ATP. NFA dose-dependently blocked ICl(Ca) in the range of 0.1–250 µM in cells dialysed with 0 mM ATP and KN-93, which contrasted with the stimulation induced by 0.1 µM, which converted to block at concentrations >1 µM when cells were dialysed with 5 mM ATP.Conclusions and implications:
Our data indicate that the presumed state of phosphorylation of the pore-forming or regulatory subunit of ClCa channels influenced the interaction of NFA in a manner that obstructs interaction of the drug with an inhibitory binding site. 相似文献308.
目的评估不同的电极密度对BEAM数据精确性的影响。方法32名年龄50~59岁正常受试者。采用1和4点插值计算方法计算平均平方根功率BEAM。对比16、20、24、28通道记录的BEAM。结果6个脑电频段61%(11/18)的高功率值电极部位不在16通道的记录电极之内。其中73%(8/11)的高功率电极位于中线电极(Fz、Cz、Pz、OZ)。16通道记录时各个频段的功率值明显降低。增加记录电极,BEAM的精确性增加。结论16通道记录的BEAM存在明显的失真,在低密度电极记录的条件下计算BEAM至少20通道。 相似文献