全文获取类型
收费全文 | 31892篇 |
免费 | 2321篇 |
国内免费 | 474篇 |
专业分类
耳鼻咽喉 | 638篇 |
儿科学 | 525篇 |
妇产科学 | 677篇 |
基础医学 | 4507篇 |
口腔科学 | 489篇 |
临床医学 | 2629篇 |
内科学 | 7270篇 |
皮肤病学 | 966篇 |
神经病学 | 2195篇 |
特种医学 | 1737篇 |
外科学 | 4274篇 |
综合类 | 539篇 |
一般理论 | 15篇 |
预防医学 | 1305篇 |
眼科学 | 929篇 |
药学 | 2765篇 |
中国医学 | 339篇 |
肿瘤学 | 2888篇 |
出版年
2023年 | 212篇 |
2022年 | 575篇 |
2021年 | 992篇 |
2020年 | 502篇 |
2019年 | 817篇 |
2018年 | 950篇 |
2017年 | 679篇 |
2016年 | 910篇 |
2015年 | 1239篇 |
2014年 | 1467篇 |
2013年 | 1686篇 |
2012年 | 2451篇 |
2011年 | 2531篇 |
2010年 | 1534篇 |
2009年 | 1312篇 |
2008年 | 1851篇 |
2007年 | 1771篇 |
2006年 | 1603篇 |
2005年 | 1530篇 |
2004年 | 1281篇 |
2003年 | 1245篇 |
2002年 | 1130篇 |
2001年 | 760篇 |
2000年 | 680篇 |
1999年 | 641篇 |
1998年 | 265篇 |
1997年 | 244篇 |
1996年 | 226篇 |
1995年 | 185篇 |
1994年 | 156篇 |
1993年 | 103篇 |
1992年 | 306篇 |
1991年 | 233篇 |
1990年 | 267篇 |
1989年 | 270篇 |
1988年 | 263篇 |
1987年 | 206篇 |
1986年 | 186篇 |
1985年 | 174篇 |
1984年 | 146篇 |
1983年 | 115篇 |
1982年 | 83篇 |
1981年 | 77篇 |
1980年 | 73篇 |
1979年 | 125篇 |
1978年 | 83篇 |
1977年 | 73篇 |
1976年 | 51篇 |
1975年 | 62篇 |
1974年 | 53篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Background
Small bowel volvulus caused by a jejunal trichobezoar is an extremely rare and life-threatening emergency in children.Case characteristics
An 8-year-old girl with abdominal pain and persistent bilious vomiting.Observation
The abdominal computed tomography scan showed a solitary intraluminal mass and a whirl sign, suggesting the small bowel volvulus. Emergency laparoscopic exploration revealed the rotated segment of small bowel loops by a jejunal trichobezoar.Outcome
Satisfactory recovery after surgery.Message
Trichobezoars should be considered in the differential diagnosis of abdominal pain and projectile vomiting in children. 相似文献993.
In Bum Suh Dae Wui Yoon Won-Oak Oh Eun Joo Lee Kyung Hoon Min Gyu Young Hur Seung Heon Lee Sung Yong Lee Sang Yeub Lee Chol Shin Jae Jeong Shim Kwang Ho In Kyung Ho Kang Je Hyeong Kim 《Journal of Korean medical science》2014,29(4):556-563
This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV) group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI) group; and 6) LPV with cystamine pretreatment (Cyst+LPV) group. Acute lung injury (ALI) score, TG2 activity and gene expression, inflammatory cytokines, and nuclear factor-κB (NF-κB) activity were measured. TG2 activity and gene expression were significantly increased in the VILI group (P < 0.05). Cystamine pretreatment significantly decreased TG2 activity and gene expression in the Cyst+VILI group (P < 0.05). Inflammatory cytokines were higher in the VILI group than in the LPS and LPV groups (P < 0.05), and significantly lower in the Cyst+VILI group than the VILI group (P < 0.05). NF-κB activity was increased in the VILI group compared with the LPS and LPV groups (P < 0.05), and significantly decreased in the Cyst+VILI group compared to the VILI group (P = 0.029). The ALI score of the Cyst+VILI group was lower than the VILI group, but the difference was not statistically significant (P = 0.105). These results suggest potential roles of TG2 in the pathogenesis of VILI.
Graphical Abstract
相似文献994.
Hyoung Su Kim Bo Youn Choi Hyeok Soo Choi Woon Geon Shin Kyung Ho Kim Jin Heon Lee Hak Yang Kim Myoung Kuk Jang Dong Joon Kim Myung Seok Lee Choong Kee Park 《Journal of Korean medical science》2014,29(4):564-569
Vertical transmission from mother to child, the main route of chronic hepatitis B virus (HBV) infection in the East Asia, is considered one of the most important predictors for the response to antiviral therapies as well as its complications such as cirrhosis and hepatocellular carcinoma. Therefore, it is critical in both etiologic and prognostic aspects to confirm whether or not chronic HBV infection is acquired vertically. This study investigated whether mother-to-child infection could be proved by the phylogenetic analyses of HBV pre-S/S genes ever since several decades have elapsed in mother-child pairs with presumed vertical transmission. The pre-S and S regions of HBVs were compared and analyzed phylogenetically in a total of 36 adults (18 mother-child pairs) with chronic HBV infection. All of the isolates of HBV were genotype C and serotype adr. The divergence between mothers and offsprings was 0 to 1.5%. Phylogenetic trees revealed that 17 of 18 pairs (94%) with presumed vertical transmission were grouped into the same cluster. Vertical transmission from mother to child could be strongly suggested even in adults with a history of several decades of HBV infection using the phylogenetic analyses of pre-S and S genes.
Graphical Abstract
相似文献995.
Joon Ho Hwang Joo Heon Kim Jung Ju Hwang Kyu Soon Kim Seung Yeon Kim 《Journal of Korean medical science》2014,29(4):609-613
Congenital pulmonary lymphangiectasia (CPL) is a rare lymphatic pulmonary abnormality. CPL with respiratory distress has a poor prognosis, and is frequently fatal in neonates. We report a case of pneumonectomy for CPL in a newborn. An infant girl, born at 39 weeks'' after an uncomplicated pregnancy, exhibited respiratory distress 1 hr after birth, which necessitated intubation and aggressive ventilator care. Right pneumonectomy was performed after her symptoms worsened. Histologic examination indicated CPL. She is currently 12 months old and developing normally. Pneumonectomy can be considered for treating respiratory symptoms for improving chances of survival in cases with unilateral CPL.
Graphical Abstract
相似文献996.
997.
Hyun Jung Kwak InA Yun Sang-Heon Kim Jang Won Sohn Dong Ho Shin Ho Joo Yoon Gheun-Ho Kim Tchun Young Lee Sung Soo Park Young-Hyo Lim 《Journal of Korean medical science》2014,29(3):423-430
The rapid response system (RRS) is an innovative system designed for in-hospital, at-risk patients but underutilization of the RRS generally results in unexpected cardiopulmonary arrests. We implemented an extended RRS (E-RRS) that was triggered by actively screening at-risk patients prior to calls from primary medical attendants. These patients were identified from laboratory data, emergency consults, and step-down units. A four-member rapid response team was assembled that included an ICU staff, and the team visited the patients more than twice per day for evaluation, triage, and treatment of the patients with evidence of acute physiological decline. The goal was to provide this treatment before the team received a call from the patient''s primary physician. We sought to describe the effectiveness of the E-RRS at preventing sudden and unexpected arrests and in-hospital mortality. Over the 1-yr intervention period, 2,722 patients were screened by the E-RRS program from 28,661 admissions. There were a total of 1,996 E-RRS activations of simple consultations for invasive procedures. After E-RRS implementation, the mean hospital code rate decreased by 31.1% and the mean in-hospital mortality rate was reduced by 15.3%. In conclusion, the implementation of E-RRS is associated with a reduction in the in-hospital code and mortality rates.
Graphical Abstract
相似文献998.
Ji Eun Lee Duck Hyun Ryu Ho Jung Jeong Jung Hoon Kim Ji Eun Jun June Soo Kim Soo Youn Lee 《Journal of Korean medical science》2014,29(9):1317-1319
A 73-yr-old Korean man with permanent atrial fibrillation visited outpatient clinic with severely increased International Normalized Ratio (INR) values after taking a usual starting dosage of warfarin to prevent thromboembolism. We found out later from his blood tests that he had hyperthyroidism at the time of treatment initiation. His genetic analysis showed CYP2C9*1/*3 and VKORC1+1173TT genotypes. We suspect that both hyperthyroidism and genetic variant would have contributed to his extremely increased INR at the beginning of warfarin therapy. From this case, we learned that pharmacogenetic and thyroid function test might be useful when deciding the starting dosage of warfarin in patients with atrial fibrillation.
Graphical Abstract
相似文献999.
Seung Eun Lee Kyung Sik Kim Wan Bae Kim In-Gyu Kim Yang Won Nah Dong Hee Ryu Joon Seong Park Myung Hee Yoon Jai Young Cho Tae Ho Hong Dae Wook Hwang Dong Wook Choi Korean Association of Hepato-Biliary Pancreas Surgery 《Journal of Korean medical science》2014,29(10):1333-1340
At present, surgical treatment is the only curative option for gallbladder (GB) cancer. Many efforts therefore have been made to improve resectability and the survival rate. However, GB cancer has a low incidence, and no randomized, controlled trials have been conducted to establish the optimal treatment modalities. The present guidelines include recent recommendations based on current understanding and highlight controversial issues that require further research. For T1a GB cancer, the optimal treatment modality is simple cholecystectomy, which can be carried out as either a laparotomy or a laparoscopic surgery. For T1b GB cancer, either simple or an extended cholecystectomy is appropriate. An extended cholecystectomy is generally recommended for patients with GB cancer at stage T2 or above. In extended cholecystectomy, a wedge resection of the GB bed or a segmentectomy IVb/V can be performed and the optimal extent of lymph node dissection should include the cystic duct lymph node, the common bile duct lymph node, the lymph nodes around the hepatoduodenal ligament (the hepatic artery and portal vein lymph nodes), and the posterior superior pancreaticoduodenal lymph node. Depending on patient status and disease severity, surgeons may decide to perform palliative surgeries.
Graphical Abstract
相似文献1000.
Hyung Ho Yoon Yong Hwan Kim Eun Sil Shin Sang Ryong Jeon 《Journal of Korean medical science》2014,29(11):1555-1561
A double toxin-double lesion strategy is well-known to generate a rat model of striatonigral degeneration (SND) such as multiple system atrophy-parkinsonian type. However, with this model it is difficult to distinguish SND from Parkinson''s disease (PD). In this study, we propose a new rat model of SND, which is generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum. Stepping tests performed 30 min after intraperitoneal L-dopa administration at 6 weeks post-surgery revealed an L-dopa response in the PD group but not the SND group. Apomorphine-induced rotation tests revealed no rotational bias in the SND group, which persisted for 2 months, but contralateral rotations in the PD group. MicroPET scans revealed glucose hypometabolism and dopamine transporter impairment on the lesioned striatum in the SND group. Tyrosine hydroxylase immunostaining in the SND group revealed that 74.7% of nigral cells on the lesioned side were lost after lesion surgery. These results suggest that the proposed simultaneous double toxin-double lesion method successfully created a rat model of SND that had behavioral outcomes, multitracer microPET evaluation, and histological aspects consistent with SND pathology. This model will be useful for future study of SND. 相似文献