全文获取类型
收费全文 | 4753篇 |
免费 | 246篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 62篇 |
妇产科学 | 34篇 |
基础医学 | 566篇 |
口腔科学 | 110篇 |
临床医学 | 241篇 |
内科学 | 1208篇 |
皮肤病学 | 159篇 |
神经病学 | 357篇 |
特种医学 | 385篇 |
外科学 | 958篇 |
综合类 | 15篇 |
预防医学 | 88篇 |
眼科学 | 24篇 |
药学 | 232篇 |
中国医学 | 11篇 |
肿瘤学 | 534篇 |
出版年
2023年 | 21篇 |
2022年 | 30篇 |
2021年 | 73篇 |
2020年 | 58篇 |
2019年 | 71篇 |
2018年 | 94篇 |
2017年 | 88篇 |
2016年 | 138篇 |
2015年 | 97篇 |
2014年 | 138篇 |
2013年 | 174篇 |
2012年 | 249篇 |
2011年 | 304篇 |
2010年 | 139篇 |
2009年 | 121篇 |
2008年 | 255篇 |
2007年 | 289篇 |
2006年 | 258篇 |
2005年 | 278篇 |
2004年 | 284篇 |
2003年 | 294篇 |
2002年 | 255篇 |
2001年 | 123篇 |
2000年 | 134篇 |
1999年 | 118篇 |
1998年 | 76篇 |
1997年 | 68篇 |
1996年 | 56篇 |
1995年 | 42篇 |
1994年 | 33篇 |
1993年 | 33篇 |
1992年 | 70篇 |
1991年 | 53篇 |
1990年 | 44篇 |
1989年 | 59篇 |
1988年 | 35篇 |
1987年 | 42篇 |
1986年 | 45篇 |
1985年 | 40篇 |
1984年 | 30篇 |
1983年 | 32篇 |
1982年 | 19篇 |
1981年 | 13篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1977年 | 9篇 |
1974年 | 15篇 |
1973年 | 10篇 |
1972年 | 14篇 |
1966年 | 15篇 |
排序方式: 共有5020条查询结果,搜索用时 234 毫秒
71.
72.
Hiroshi Ochi Lecturer Keiichi Matsubara Assistant Yasuki Kusanagi Assistant Humiaki Taniguchi Assistant Masaharu Ito Professor 《BJOG : an international journal of obstetrics and gynaecology》1998,105(10):1118-1121
Objective To investigate the relation between placental embolisation and the diastolic notch in the uterine artery flow velocity waveform of pregnant ewes under general anaesthesia.
Methods Seven pregnant ewes at a gestation 16 to 17 weeks were anaesthesized and micro beads of gelfoam were injected into the uterine artery; changes in the uterine circulation were assessed by Doppler velocimetry.
Results Gelfoam embolisation reduced uterine blood flow in a dose-dependent manner, from a mean (95% CI) of 568 mL/min (495–641) to 159 mL/min (131–187) after the injection of 30 mg of gelfoam, and increased the uterine vascular resistance from 135 mmHg mine L−1 (103–167) to 498 mmHg mino L−1 (422–574). A diastolic notch in uterine artery flow velocity waveform was observed after 20 mg to 25 mg of gelfoam in two ewes and after injection of 30 mg of gelfoam in all seven animals. Injection of 30 mg of gelfoam increased the pulsatility index to 2–4 (1.9–2.9) from 0.6 (0.5–0.7). The mean uterine vascular resistance at the time of the appearance of a diastolic notch was 414 mmHg mine L−1 (377–451).
Conclusion These findings suggest that an elevated pulsatility index and the presence of a diastolic notch in the uterine artery flow velocity waveform are indicators of increased uterine vascular resistance and impaired uterine circulation. 相似文献
Methods Seven pregnant ewes at a gestation 16 to 17 weeks were anaesthesized and micro beads of gelfoam were injected into the uterine artery; changes in the uterine circulation were assessed by Doppler velocimetry.
Results Gelfoam embolisation reduced uterine blood flow in a dose-dependent manner, from a mean (95% CI) of 568 mL/min (495–641) to 159 mL/min (131–187) after the injection of 30 mg of gelfoam, and increased the uterine vascular resistance from 135 mmHg mine L
Conclusion These findings suggest that an elevated pulsatility index and the presence of a diastolic notch in the uterine artery flow velocity waveform are indicators of increased uterine vascular resistance and impaired uterine circulation. 相似文献
73.
Hironobu Shibata Masahiro Abe Kenji Hiura Javier Wilde Keiji Moriyama Toshiaki Sano Ken-Ichi Kitazoe Toshihiro Hashimoto Shuji Ozaki Shingo Wakatsuki Shinsuke Kido Daisuke Inoue Toshio Matsumoto 《Clinical cancer research》2005,11(17):6109-6115
PURPOSE: Receptor activator of nuclear factor-kappaB ligand (RANKL) is a key mediator of osteoclastogenesis. Because certain types of tumor cells aberrantly express RANKL, and because bone destruction also develops in B-cell lymphomas of bone origin, we investigated RANKL expression and the mechanisms of osteoclastogenesis in B-lymphoid neoplasms. EXPERIMENTAL DESIGN AND RESULTS: Immunohistochemistry of bone specimens resected from patients with primary B-cell lymphoma of bone with bone destruction revealed that lymphoma cells express RANKL as well as vascular endothelial cell growth factor (VEGF). The tumor cells isolated from the bone specimens enhanced osteoclastogenesis in vitro. In contrast, B-cell lymphoma infiltrating to the bone marrow without bone destruction did not express RANKL. Both RANKL and VEGF were expressed by a portion of B-lymphoid cell lines, including Daudi and IM-9. These RANKL-expressing tumor cells enhanced osteoclastogenesis from RAW264.7 cells and human monocyte-derived preosteoclasts in the absence of stromal cells/osteoblasts in a RANKL-dependent manner. Furthermore, conditioned media from Daudi cells enhanced transmigration of preosteoclasts that was inhibited by anti-VEGF antibody, suggesting that tumor cell-derived VEGF mediates recruitment of osteoclast precursors. Moreover, cocultures of B-lymphoid cell lines with osteoclasts enhanced the growth of B-lymphoid cells. CONCLUSIONS: Some malignant B cells aberrantly express functional RANKL as well as VEGF to enhance osteoclastogenesis. The coexpression of RANKL and VEGF may also contribute to the close cellular interactions with osteoclastic cells, thereby forming a vicious cycle between osteoclastic bone destruction and tumor expansion in bone. 相似文献
74.
Nishiguchi S Shiomi S Sasaki N Iwata Y Tanaka H Kubo S Hirohashi K Ochi H 《Annals of nuclear medicine》2000,14(5):383-386
A 39-year-old woman with acute cholecystitis and gallstones underwent laparoscopic cholecystectomy. She suffered from recurrent episodes of cholangitis due to injury of the major bile ducts during laparoscopic cholecystectomy. Hepatobiliary scintigraphy with Tc-99m Sn-N-pyridoxyl-5-methyltryptophan was performed. Although normal bile excretion was found from the left hepatic duct to the percutaneous transhepatic biliary drainage (PTBD) tube, excretion from the right hepatic lobe was prolonged. Scintigraphy with Tc-99m diethylenetriaminepentaacetic acid-galactosyl human serum albumin demonstrated atrophy of the right hepatic lobe and enlargement of the left hepatic lobe. Cholangiography via the PTBD tube revealed complete obstruction of the left hepatico-jejunal anastomosis and could not enhance the right intrahepatic bile duct. A right hepatic lobectomy was performed because of the atrophy, glissonitis and the absence of an appropriate bile duct for reconstruction. Postoperatively she was active and exhibited no evidence of recurrent cholangitis. 相似文献
75.
Real‐world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus‐infected cirrhosis patients 下载免费PDF全文
Kei Morio Michio Imamura Yoshiiku Kawakami Reona Morio Tomoki Kobayashi Satoe Yokoyama Yuko Nagaoki Tomokazu Kawaoka Masataka Tsuge Akira Hiramatsu Grace Naswa Makokha C Nelson Hayes Hiroshi Aikata Daiki Miki Hidenori Ochi Yoji Honda Nami Mori Shintaro Takaki Keiji Tsuji Kazuaki Chayama 《Journal of gastroenterology and hepatology》2017,32(3):645-650
76.
77.
78.
79.
Maeda N Osuga K Higashihara H Tomoda K Mikami K Nakazawa T Nakamura H Tomiyama N 《Cardiovascular and interventional radiology》2012,35(1):82-89