全文获取类型
收费全文 | 2921篇 |
免费 | 178篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 53篇 |
妇产科学 | 51篇 |
基础医学 | 342篇 |
口腔科学 | 41篇 |
临床医学 | 231篇 |
内科学 | 851篇 |
皮肤病学 | 67篇 |
神经病学 | 135篇 |
特种医学 | 167篇 |
外科学 | 415篇 |
综合类 | 20篇 |
预防医学 | 63篇 |
眼科学 | 50篇 |
药学 | 279篇 |
中国医学 | 8篇 |
肿瘤学 | 300篇 |
出版年
2023年 | 26篇 |
2022年 | 35篇 |
2021年 | 40篇 |
2020年 | 42篇 |
2019年 | 43篇 |
2018年 | 80篇 |
2017年 | 51篇 |
2016年 | 62篇 |
2015年 | 58篇 |
2014年 | 82篇 |
2013年 | 73篇 |
2012年 | 178篇 |
2011年 | 135篇 |
2010年 | 108篇 |
2009年 | 81篇 |
2008年 | 167篇 |
2007年 | 133篇 |
2006年 | 143篇 |
2005年 | 147篇 |
2004年 | 136篇 |
2003年 | 148篇 |
2002年 | 137篇 |
2001年 | 76篇 |
2000年 | 77篇 |
1999年 | 101篇 |
1998年 | 32篇 |
1997年 | 39篇 |
1996年 | 32篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 21篇 |
1992年 | 73篇 |
1991年 | 59篇 |
1990年 | 57篇 |
1989年 | 42篇 |
1988年 | 42篇 |
1987年 | 39篇 |
1986年 | 46篇 |
1985年 | 37篇 |
1984年 | 29篇 |
1983年 | 23篇 |
1982年 | 10篇 |
1981年 | 16篇 |
1980年 | 12篇 |
1979年 | 17篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1975年 | 9篇 |
1973年 | 6篇 |
1969年 | 12篇 |
排序方式: 共有3115条查询结果,搜索用时 11 毫秒
61.
Shoichiro Sumi MD Dr. Kazutomo Inoue MD Masafumi Kogire MD Ryuichiro Doi MD Mitsutoshi Yun MD Hiromu Kaji MD Ryo Hosotani MD Masaki Fujimura MD Kotaro Uchida MD Shinya Kiyama PhD Kouki Kitagawa PhD Haruaki Yajima PhD Nobutaka Fujii PhD Takayoshi Tobe MD 《Digestive diseases and sciences》1991,36(11):1523-1528
This study examined the effect of synthetic porcine neuropeptide Y on the splanchnic blood flows and the exocrine pancreatic secretion in dogs. Graded doses of neuropeptide Y (0.1–5 g/kg, intravenous) caused dose-dependent reduction of the secretin-stimulated exocrine pancreatic secretion and of the blood flows in the superior mesenteric artery, the portal vein, and the pancreatic tissue. Neuropeptide Y at 5 g/kg reduced the blood flows to 45.9±13.3% (superior mesenteric artery), 63.0±10.5% (portal vein), and 77.9±4.8% (pancreatic tissue), respectively. This dose also reduced secretin-stimulated pancreatic juice volume and CCK-8 plus secretin-stimulated protein output to 65.2±9.3 and 63.3±14.0%, respectively. This study shows a potent vasoconstrictor effect of neuropeptide Y on splanchnic vessels. Neuropeptide Y also inhibited exocrine pancreatic secretion in a significant correlation with the reduction in pancreatic tissue blood flow, which suggests that reduction in the blood flow may be one of the possible mechanisms of the inhibitory action of neuropeptide Y on exocrine secretion.This work was supported by a grant from the Ministry of Education, Japan (A-61440060). 相似文献
62.
Kentaro Sada Shuji Hidaka Nao Imaishi Kohei Shibata Rumi Katashima Shinsuke Noso Hiroshi Ikegami Tetsuya Kakuma Hirotaka Shibata 《Journal of diabetes investigation.》2020,11(3):573-577
We report the identification of a mutation in the solute carrier family 5 member 2 (SLC5A2) gene, which encodes sodium–glucose cotransporter 2, in a family with familial renal glucosuria. The proband was a 26‐year‐old Japanese man referred to the diabetes division with repeated glucosuria without hyperglycemia. His mother, uncle and grandfather also had a history of glucosuria. A heterozygous missense mutation (c.303T>A:p.N101K) in SLC5A2 was identified in the patient and his mother, but not in 200 chromosomes from 100 healthy and unrelated individuals, or in 3,408 Japanese individuals in the Tohoku Medical Megabank. Furthermore, bioinformatics software predicted that this lesion would be pathogenic. We infer that the mutation led to clinically relevant sodium–glucose cotransporter 2 dysfunction. The patient showed no symptoms of hypoglycemia, but continuous glucose monitoring confirmed asymptomatic hypoglycemia. 相似文献
63.
Hirofumi Matsumoto Tomoshi Tsuchiya Koh-ichiro Yoshiura Tomayoshi Hayashi Shigekazu Hidaka Atsushi Nanashima Takeshi Nagayasu 《ACTA HISTOCHEMICA ET CYTOCHEMICA》2014,47(3):85-94
ATP-binding cassette (ABC) transporters are involved in chemotherapy resistance. Multidrug-resistance protein 8 (ABCC11/MRP8) is also involved in 5-fluorouracil (5-FU) metabolism. 5-FU and its derivatives are widely used in the treatment of gastrointestinal tract cancers, but little is known about the contribution of ABCC11/MRP8 to gastrointestinal tract and related cancers. Here, we report our investigation of ABCC11/MRP8 expression in normal and cancerous gastrointestinal tract tissues and reveal its novel role in the gastric mucosa. In tissue microarray and surgically resected cancer specimens, immunohistochemical (IHC) staining revealed significantly reduced expression of ABCC11/MRP8 in gastrointestinal tract cancers compared with other cancers. In contrast, strong ABCC11/MRP8 expression was observed in normal gastric mucosa. Additional immunofluorescence assays revealed co-localization of ABCC11/MRP8 and pepsinogen I in normal gastric chief cells. Quantitative PCR and Western blot analysis also revealed significant expression of ABCC11/MRP8 in fundic mucosa where the chief cells are mainly located. Furthermore, the ABCC11 mRNA-suppressed NCI-N87 gastric cancer cell line failed to secret pepsinogen I extracellularly. Thus, low expression of ABCC11/MRP8 is consistent with chemotherapeutic regimens using 5-FU and its derivatives in gastrointestinal tract cancers. Our results indicated a novel function of ABCC11/MRP8 in the regulation of pepsinogen I secretion in the normal gastric chief cells. 相似文献
64.
Xue Shao Haruki Uojima Toru Setsu Tomomi Okubo Masanori Atsukawa Yoshihiro Furuichi Yoshitaka Arase Hisashi Hidaka Yoshiaki Tanaka Takahide Nakazawa Makoto Kako Tatehiro Kagawa Katsuhiko Iwakiri Shuji Terai Wasaburo Koizumi 《World journal of gastroenterology : WJG》2020,26(1):97-108
BACKGROUND Autotaxin(ATX) has been reported as a direct biomarker for estimating the evaluation of liver fibrosis. But available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC) are scant.AIM To assess the clinical usefulness of ATX for assessing the complications of LC.METHODS This multicenter, retrospective study was conducted at six locations in Japan. We include patients with LC, n = 400. The ATX level was evaluated separately in men and women because of its high level in female patients. To assess the clinical usefulness of ATX for the complications of LC, the area under the curve(AUC) of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score, albumin-bilirubin(ALBI) score, fibrosis-4 index, and aspartate aminotransferase-to-platelet ratio index.RESULTS The mean age was 68.4 ± 11.4 years, 240 patients(60.0%) were male. A total of 213(53.3%) and 187(46.8%) patients were compensated and decompensated,respectively. The numbers of patients with varix rupture, hepatic ascites, and hepatic encephalopathy were 35(8.8%), 131(32.8%), and 103(25.8%),respectively. The AUCs of ATX in men for hepatic encephalopathy, hepatic ascites, and varix ruptures were 0.853, 0.816, and 0.706, respectively. The AUCs of ATX in women for hepatic encephalopathy, hepatic ascites, and varix rupture were 0.759, 0.717, and 0.697, respectively. The AUCs of ATX in men were higher than those in women, as were all the other biomarkers used to detect encephalopathy and varix ruptures. However, for detecting ascites, the AUC of ALBI in men was more effective than using ATX.CONCLUSION ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures. 相似文献
65.
Nobuhiro Yoshijima Ryo Yanagisawa Hiromu Hase Makoto Tanaka Hikaru Tsuruta Hideyuki Shimizu Keiichi Fukuda Toru Naganuma Kazuki Mizutani Motoharu Araki Norio Tada Futoshi Yamanaka Shinichi Shirai Minoru Tabata Hiroshi Ueno Kensuke Takagi Akihiro Higashimori Yusuke Watanabe Masanori Yamamoto Kentaro Hayashida 《Catheterization and cardiovascular interventions》2020,95(1):35-44
66.
Rei Isshiki Shuzo Kobayashi Masao Iwagami Daimu Tsutumi Yasuhiro Mochida Kunihiro Ishioka Machiko Oka Kyoko Maesato Hidekazu Moriya Takayasu Ohtake Sumi Hidaka 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2014,18(3):291-296
Cognitive impairment has long been recognized as a complication of chronic kidney disease. However, there is little information available regarding regional cerebral blood flow (rCBF) in patients with peritoneal dialysis (PD). Therefore, we evaluated rCBF using brain single photon emission computed tomography (SPECT). We conducted a cross‐sectional study in our hospital. Eighteen consecutive PD patients who could visit the hospital by themselves without any history of stroke were examined by Technetium‐99 m‐labeled ethylcrysteinate dimer brain SPECT. An easy Z‐score imaging system (eZIS) was used to compare rCBF in PD patients with those in age‐matched healthy controls. We also evaluated cognitive dysfunction with the mini‐mental state examination (MMSE) questionnaire. Only one patient showed an MMSE score of 18 points, and the remaining 14 patients were considered as normal (MMSE ≥ 27), and three patients were considered to have mild cognitive impairment (24 ≤ MMSE ≤ 26). In all patients, rCBF in the posterior cingulated gyri, precunei, and parietal cortices was significantly decreased. The ratio of the reduction of rCBF in each region relative to that of rCBF across the whole brain correlated positively with the PD duration (r = 0.559; P < 0.05). The serum β2‐microglobulin level was significantly higher in patients who had a higher ratio of rCBF reduction compared with those with lower ratios. In conclusion, all PD patients in the present study had decreased rCBF irrespective of MMSE scores. 相似文献
67.
Feasibility of one‐step endoscopic metal stenting for distal malignant biliary obstruction
下载免费PDF全文
![点击此处可从《Journal of hepato-biliary-pancreatic sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
68.
There are difficulties in conducting worldwide medical device development simultaneously because each country and/or region has their own medical device regulations. However, to aid globalization of the medical device market, and to quickly provide innovative medical devices to patients, attempts have been made to encourage harmonization and convergence of medical device regulations. ‘Harmonization by doing’ is a bilateral effort from the United States and Japan to develop global clinical trials and address regulatory barriers that may be impediments to timely device approval. The Global Harmonization Task Force (GHTF) was conceived in 1992 in an effort to achieve greater uniformity between national medical device regulatory systems. Since 2012, the GHTF has been replaced by the International Medical Device Regulators Forum. 相似文献
69.
Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan
下载免费PDF全文
![点击此处可从《Journal of hepato-biliary-pancreatic sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shoji Kubo Yasuni Nakanuma Shigekazu Takemura Chikaharu Sakata Yorihisa Urata Akinori Nozawa Takayoshi Nishioka Masahiko Kinoshita Genya Hamano Hiroaki Terajima Gorou Tachiyama Yuji Matsumura Terumasa Yamada Hiromu Tanaka Shoji Nakamori Akira Arimoto Norifumi Kawada Masahiro Fujikawa Hiromitsu Fujishima Yasuhiko Sugawara Shogo Tanaka Hideyoshi Toyokawa Yuko Kuwae Masahiko Ohsawa Shinichiro Uehara Kyoko Kogawa Sato Tomoshige Hayashi Ginji Endo 《Journal of hepato-biliary-pancreatic sciences》2014,21(7):479-488
70.