全文获取类型
收费全文 | 23093篇 |
免费 | 1205篇 |
国内免费 | 151篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 347篇 |
妇产科学 | 218篇 |
基础医学 | 2748篇 |
口腔科学 | 499篇 |
临床医学 | 1558篇 |
内科学 | 5732篇 |
皮肤病学 | 1153篇 |
神经病学 | 2000篇 |
特种医学 | 1052篇 |
外科学 | 3871篇 |
综合类 | 136篇 |
预防医学 | 595篇 |
眼科学 | 210篇 |
药学 | 1778篇 |
中国医学 | 42篇 |
肿瘤学 | 2343篇 |
出版年
2023年 | 199篇 |
2022年 | 372篇 |
2021年 | 640篇 |
2020年 | 330篇 |
2019年 | 417篇 |
2018年 | 586篇 |
2017年 | 409篇 |
2016年 | 504篇 |
2015年 | 483篇 |
2014年 | 671篇 |
2013年 | 712篇 |
2012年 | 1198篇 |
2011年 | 1224篇 |
2010年 | 697篇 |
2009年 | 582篇 |
2008年 | 1083篇 |
2007年 | 1095篇 |
2006年 | 1054篇 |
2005年 | 1033篇 |
2004年 | 1044篇 |
2003年 | 1032篇 |
2002年 | 948篇 |
2001年 | 635篇 |
2000年 | 695篇 |
1999年 | 675篇 |
1998年 | 328篇 |
1997年 | 234篇 |
1996年 | 222篇 |
1995年 | 187篇 |
1994年 | 158篇 |
1993年 | 139篇 |
1992年 | 467篇 |
1991年 | 418篇 |
1990年 | 416篇 |
1989年 | 429篇 |
1988年 | 409篇 |
1987年 | 374篇 |
1986年 | 330篇 |
1985年 | 288篇 |
1984年 | 175篇 |
1983年 | 153篇 |
1982年 | 83篇 |
1979年 | 164篇 |
1978年 | 86篇 |
1977年 | 86篇 |
1974年 | 73篇 |
1973年 | 86篇 |
1972年 | 84篇 |
1970年 | 77篇 |
1968年 | 75篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Tsuyoshi Satoh Tadashi Watanabe Masanori Tadokoro Junichi Sakamoto Hiroki Murayama Katsuki Itoh Sadayuki Sakuma Hiroshi Takagi 《Cancer science》1992,83(4):379-386
Anti-carcinoembryonic antigen monoclonal antibody (MAb) CEA102 was produced by immunization with purified CEA and the specific accumulation of radiolabeled CEA102 in colorectal cancers was investigated by autoradiography of surgical specimens using Fuji Computed Radiography (FCR). Five patients with colorectal cancer were injected intravenously with 131 I-labeled intact CEA102 or its F(ab')2 . Primary tumor and liver metastases were successfully detected by external scanning with a gamma camera in 4 cases. Autoradiographic study of the surgical specimens using FCR showed predominant localization of 131 I-labeled CEA102 in primary tumors and liver metastases in all cases. Even a small liver metastasis (0.5 cm) was clearly visualized in the autoradiogram by FCR. The pixel distribution curves of the density of the respective tissues in the autoradiograms by FCR showed the heterogeneity of the distribution of administered radiolabeled MAb in individual tumors, but the density of the tumors was higher than that of the normal tissues. In the quantitative distribution analysis of CEA102, the uptake of the primary tumor (mean 1.10%ID/kg) was ten-fold greater than that of the normal colon mucosa (mean G.10%ID/kg). These results revealed that the application of MAb has great potential in radioimmunodetection as well as in antibody-directed therapy. 相似文献
62.
We have successfully applied a reverse flow island flap of extensor digitorum brevis muscle for coverage of tissue defects in the distal portion of the foot dorsum in 2 patients. This flap covered the metatarsophalangeal area well with cadaver limb dissection and seems useful to cover the defect in the distal foot dorsum. 相似文献
63.
Takao Hashimoto Osamu Sasaki Kunihiro Yoshida Yo-ichi Takei Shu-ichi Ikeda 《Movement disorders》2003,18(10):1201-1204
We report on a family with ataxia type 6 (SCA6) showing peculiar oculomotor symptoms. The proband presented with periodic alternating nystagmus (PAN), and her 2 brothers had rebound nystagmus and gaze-evoked nystagmus. They carried the identical mutation (the number of expanded CAG repeat, 24) in the CACNA1A gene. The intrafamilial variability of oculomotor symptoms may be ascribed to factors other than CAG repeat expansion size in SCA6. 相似文献
64.
Sadahisa Okamoto Yuichiro Inatomi Toshiro Yonehara Yoichiro Hashimoto Teruyuki Hirano Makoto Uchino 《Clinical neurology》2006,46(5):307-311
In order to determine predictive factors of early seizures (ES) after acute stroke and to estimate prognosis, we retrospectively examined clinical data of 1,743 consecutive patients with acute ischemic stroke. The subjects were divided into two groups; an ES group (19 patients) and a non-ES group (1,724 patients). Multivariate statistical analysis revealed that the NIH-Stroke Scale score on admission (/10, OR, 1.1: 95% CI 1.04 to 1.13) and positive past history of cerebrovascular disease or brain injury (OR, 3.85: 95% CI 1.49 to 9.95) are significant factors to predict ES. There was no significant difference in the outcome between the two groups. A recurrence of seizures, after follow up for 4 to 40 months, was observed only in one patient with a history of ES. 相似文献
65.
Kazuhiro Masada Masataka Yasuda Eiji Takeuchi Hideo Hashimoto 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2003,37(3):155-158
We did 18 arthrodeses of the wrist in 16 patients with rheumatoid arthritis using an intramedullary fixation technique. There were 15 women and one man, whose ages at operation ranged from 47 to 71 years (mean 58). Follow up ranged from 13 to 68 months (mean 27). The operative technique consists of a combination of intramedullary placement of two Kirschner (K)-wires and an autogenous bone graft. At follow up bony union was apparent in all cases. K-wires came out of the metacarpal joints in two cases. Paraesthesiae in the median nerve distribution occurred in two cases which both recovered within three months. 相似文献
66.
Antibodies to beta 2-microglobulin (beta 2m), the light-chain component of class I histocompatibility antigens, provide a strong co-stimulatory signal to human lymphocytes in the presence of phorbol ester. This activation signal requires a high concentration of antibody, whereas the effect on responses to a mitogenic lectin is exclusively inhibitory over a broad dose range. A rabbit polyclonal and a mouse monoclonal antibody to beta 2m were similarly co-stimulatory. Antibody to beta 2m was co-stimulatory with phorbol ester, but not calcium ionophore, suggesting that class I antigens play a role in the initiation of the 'first' signal of a recently described two-signal model of lymphocyte activation. 相似文献
67.
68.
69.
The ascidian tadpole larva represents the basic body plan of all chordates in a relatively small number of cells and tissue types. Although it had been considered that ascidians develop largely in a determinative way, whereas vertebrates develop in an inductive way, recent studies at the molecular and cellular levels have uncovered several similarities in the way developmental fates are specified. In this review, we describe ascidian embryogenesis and its cell lineages, introduce several characteristics of ascidian embryos, describe recent advances in understanding of the mechanisms of cell fate specification, and discuss them in the context of what is known in vertebrates and other organisms. Developmental Dynamics 236:1748–1757, 2007. © 2007 Wiley‐Liss, Inc. 相似文献
70.
Presynaptic muscarinic and alpha-adrenoceptor-mediated regulation of GABA release from myenteric neurones of the guinea-pig small intestine. 总被引:1,自引:1,他引:0
下载免费PDF全文
![点击此处可从《British journal of pharmacology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The effects of cholinomimetic and sympathomimetic drugs on the release of [3H]-gamma-aminobutyric acid ([3H]-GABA) evoked by high K+ from the isolated small intestine of the guinea-pig were investigated, in the presence of tetrodotoxin. Acetylcholine and oxotremorine, at concentrations ranging from 10(-9) to 10(-6) M inhibited the evoked release of [3H]-GABA in a concentration-dependent manner, while nicotine was without effect. Scopolamine and pirenzepine inhibited the effect of oxotremorine, while hexamethonium had no effect. The IC50 values for scopolamine and pirenzepine of the oxotremorine (3 X 10(-8) M)-induced inhibition were 1.02 X 10(-9) M and 9.78 X 10(-10) M, respectively. Noradrenaline, but not isoprenaline inhibited the evoked release of [3H]-GABA. Clonidine (10(-10)-10(-6) M) reduced the evoked release of [3H]-GABA in a concentration-dependent manner, but phenylephrine had no effect. The inhibitory effect of clonidine was antagonized by yohimbine but not by prazosin. These findings provide evidence for the localization of M1-muscarinic and alpha 2-adrenoceptors on GABAergic nerve terminals and their involvement in the presynaptic control of the release of GABA from the guinea-pig small intestine. 相似文献