Zur Indikation der Cholecystektomie bei steinfreien Gallenblasen

Zusammenfassung Bei der Cholecystektomie der steinfreien Gallenblasen ist zwischen derrelativen und derabsoluten Indikation zur Operation zu unterscheiden. W?hrend man bei der relativen Indikation (Deformit?ten, Funktionsst?rungen, Syphopathien und dergleichen) zurückhaltend ist, sollte die absolute Indikation gro?zügig gestellt werden. Es handelt sich hierbei in erster Linie um chronische Cholecystitiden mit Wandfibrose, um benigne und maligne Tumoren, um die Cysticusstenose mit Ver?nderungen an der Gallenblase und um die Cholesterose (Stippchengallenblase). Nachuntersuchungen von Patienten, bei denen wegen steinfreier Cholesterose eine Cholecystektomie durchgeführt worden war, lie?en ein günstiges Ergebnis erkennen.

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Summary In patients undergoing cholecystectomy for gall-bladders without stones one must differentiate between therelative and theabsolute indication for surgery. Whereas one uses reservation as far as the relative indications are concerned (deformities, functional disorders, syphopathies etc.), the absolute indications should be stated more liberally. These are mainly chronic cholecystitis with fibrosis of the wall, benign and malignant tumors, duct stenosis with changes of the gallbladder and cholesterosis (strawberry gall-bladder). Follow-up examinations of patients who underwent cholecystectomy for cholesterosis without stones showed a favourable result.

     

异戊塞平和克塞平对大鼠脑内各受体亲和力的比较及慢性给药后的受体下调作用

用放射配体受体结合法测定表明:克塞平对多巴胺D_1受体的亲和力较异戊塞平高近20倍。两药对其它各受体的亲和力差別不大。慢性给药后,异戊塞平和克塞平均能使大鼠脑皮层5-HT_2受体的密度显著下降,而亲和力变化不明显。这种下调5-HT_2受体的作用发生在给异戊塞平后1～2周之间,给克塞平后的2～3周之间。慢性给药3周,异戊塞平和克塞平均未使大鼠脑皮层的β受体密度及亲和力产生显著变化。     

Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma

Background  

This study evaluates the existence of numerical alterations of chromosome 17 and TP53 gene deletion in gastric adenocarcinoma. The p53 protein expression was also evaluated, as well as, possible associations with clinicopathological characteristics.     

Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients

Tumor Biology - Cancers arising from the large intestine or rectum are called colorectal cancer (CRC) and represent the fourth leading cause of cancer-related death worldwide. Since casein kinase 1...