CLINICOPATHOLOGICAL STUDY ON PLASMA CELL OSTEOMYELITIS

Clinicopathologic findings of a case of chronic plasma cell ostoemyelitis of a sixteen years old Japanese boy who underwent surgery under the diagnosis of malignant bone tumor of the proximal tibial metaphysis, have been presented. Sixty-one cases of chronic plasma cell osteomyelitis including this case were reviewed. The authors described that it is necessary to make a careful differentiation between these cases and solitary myeloma clinically and microscopically.     

Effect of corticosteroids in the hippocampus on passive avoidance behavior in the rat

The site of action of corticosteroids in avoidance learning was investigated in 110 rats. Injection of cycloheximide, 30 min before one-trial training on a passive avoidance task suppressed corticosteroid secretion in response to footshock, and produced an avoidance deficit in a test 6 days later. However, an additional injection of hydrocortisone, either subcutaneously or intra-hippocampally within 5 min of training, restored the avoidance response in the test. Septal and hypothalamic injections of the hormone were ineffective in reversing the cycloheximide effect, whereas the effect of hormone injection into the amygdala was equivocal because of an increased level of activity. Corticosteroids secreted following an aversive experience appear to act upon the steroid-sensitive neurons in the hippocampus to influence the animal's later performance of passive avoidance response.     

A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure.

For a better understanding of absorption, distribution, excretion, and metabolism of trichloroethylene the time-course of blood concentration of the vapour and urinary excretion of its metabolites was examined using a pharmacokinetic model. After a single experimental exposure in which four men inhaled 100 parts per million (ppm) of trichloroethylene for four hours an elimination curve showed three exponential components, that is, X=1-0005e(-16.71t)+0-449e(-1.710t)+0-255e(-0.2027t), where X is that blood concentration in mg/l and t the time in hours from 0 to 10. The overall rate constant for the disappearance of trichloroethylene was found to a agree with the theoretical one, estimated by means of a mathematical model for the blood concentration data. A D8- XD plot, developed from a mathematical model for urinary excretion, could also give a good estimate of rate constant for the transfer of trichloroethylene in the body. The rate constant thus estimated from urinary excretion was consistent with data on the blood concentration.