INFLUENZA : II. EFFECT OF INFLUENZA VIRUS MULTIPLICATION ON THE OXYGEN CONSUMPTION CURVES OF EMBRYONATED EGGS INCUBATED AT DIFFERENT TEMPERATURES

In addition to the cycles of growth shown by the influenza A virus during the first 24 hours of its residence in the fertile egg, cycles separated by longer time intervals have been noted between the 24th and 96th hours. These longer cycles are best seen when the eggs are incubated at 40°C. Corresponding fairly accurately with these cycles of growth of the virus, wide cyclic variations in the rates of increase in oxygen consumption of the infected eggs have been found to occur. These variations are in striking contrast to the uniformity of increase noted in uninfected eggs. The variations in infectivity may be caused by periodic interference with virus multiplication by accumulated inactive virus particles. The variations in oxygen consumption probably are correlated with variations in the concentration of virus toxins.     

Pulmonary Function in Scleroderma

Pulmonary function tests were performed in 45 patients with scleroderma. Thirteen patients (29%) were found to have restrictive disease, 12 patients (27%) were found to have obstructive disease, and 19 patients (42%) had small airway disease (SAD). Smoking did not seem to be a factor underlying either obstructive or small airway disease in these patients. A low diffusing capacity was most common in patients with restrictive disease and rarely the only abnormality in pulmonary function. SAD was usually found in patients who had normal chest radiographs and no pulmonary symptoms and was often the only abnormality. SAD is therefore an early and sensitive indicator of pulmonary involvement in scleroderma.     

Synovectomy and total joint arthroplasty for recurrent hemarthroses in the arthropathic joint in hemophilia

Severe hemophiliacs with intractable bleeding into one or more joints despite adequate clotting factor replacement therapy are difficult management problems. Synovectomy has controlled bleeding only in joints without significant arthritic destruction. Total joint replacements have been performed in arthropathic joints, but not when uncontrolled bleeding was a concurrent problem. This report describes a hemophiliac with uncontrolled bleeding into an arthritic knee who was successfully managed by combining synovectomy with total knee replacement.     

A Clinical Interpretation of the “Colicky” Infant

Acridine-orange fluorescence microscopy for cytodiagnosis of cancer introduces new cytochemical criteria based on the increase of nucleic acids in malignant cells.

Application of this technic results in a highly polychromatic picture which conspicuously reveals the presence of suspicious or malignant cells. Morphologic diagnostic criteria are clearly presented for cytologic evaluation.

The procedure may be performed quickly and by relatively untrained personnel. The results achieved equal those obtained with conventional cytodiagnostic methods.