全文获取类型
收费全文 | 2097篇 |
免费 | 153篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 138篇 |
妇产科学 | 24篇 |
基础医学 | 217篇 |
口腔科学 | 70篇 |
临床医学 | 199篇 |
内科学 | 423篇 |
皮肤病学 | 42篇 |
神经病学 | 88篇 |
特种医学 | 378篇 |
外科学 | 164篇 |
综合类 | 65篇 |
预防医学 | 152篇 |
眼科学 | 25篇 |
药学 | 125篇 |
中国医学 | 10篇 |
肿瘤学 | 62篇 |
出版年
2021年 | 12篇 |
2020年 | 18篇 |
2019年 | 23篇 |
2018年 | 21篇 |
2017年 | 19篇 |
2016年 | 21篇 |
2015年 | 33篇 |
2014年 | 64篇 |
2013年 | 94篇 |
2012年 | 71篇 |
2011年 | 72篇 |
2010年 | 64篇 |
2009年 | 83篇 |
2008年 | 74篇 |
2007年 | 94篇 |
2006年 | 68篇 |
2005年 | 85篇 |
2004年 | 63篇 |
2003年 | 55篇 |
2002年 | 58篇 |
2001年 | 50篇 |
2000年 | 65篇 |
1999年 | 55篇 |
1998年 | 92篇 |
1997年 | 70篇 |
1996年 | 72篇 |
1995年 | 54篇 |
1994年 | 59篇 |
1993年 | 57篇 |
1992年 | 29篇 |
1991年 | 34篇 |
1990年 | 39篇 |
1989年 | 59篇 |
1988年 | 48篇 |
1987年 | 47篇 |
1986年 | 45篇 |
1985年 | 27篇 |
1984年 | 30篇 |
1983年 | 29篇 |
1982年 | 27篇 |
1981年 | 27篇 |
1980年 | 17篇 |
1979年 | 21篇 |
1978年 | 19篇 |
1977年 | 23篇 |
1976年 | 8篇 |
1975年 | 15篇 |
1973年 | 12篇 |
1972年 | 4篇 |
1970年 | 5篇 |
排序方式: 共有2259条查询结果,搜索用时 15 毫秒
101.
Zhongjie Li Shengjie Lai Honglong Zhang Liping Wang Dinglun Zhou Jizeng Liu Yajia Lan Jiaqi Ma Hongjie Yu David L Buckeridge Chakrarat Pittayawonganan Archie CA Clements Wenbiao Hu Weizhong Yang 《Bulletin of the World Health Organization》2014,92(9):656-663
Objective
To evaluate the performance of China’s infectious disease automated alert and response system in the detection of outbreaks of hand, foot and mouth (HFM) disease.Methods
We estimated size, duration and delay in reporting HFM disease outbreaks from cases notified between 1 May 2008 and 30 April 2010 and between 1 May 2010 and 30 April 2012, before and after automatic alert and response included HFM disease. Sensitivity, specificity and timeliness of detection of aberrations in the incidence of HFM disease outbreaks were estimated by comparing automated detections to observations of public health staff.Findings
The alert and response system recorded 106 005 aberrations in the incidence of HFM disease between 1 May 2010 and 30 April 2012 – a mean of 5.6 aberrations per 100 days in each county that reported HFM disease. The response system had a sensitivity of 92.7% and a specificity of 95.0%. The mean delay between the reporting of the first case of an outbreak and detection of that outbreak by the response system was 2.1 days. Between the first and second study periods, the mean size of an HFM disease outbreak decreased from 19.4 to 15.8 cases and the mean interval between the onset and initial reporting of such an outbreak to the public health emergency reporting system decreased from 10.0 to 9.1 days.Conclusion
The automated alert and response system shows good sensitivity in the detection of HFM disease outbreaks and appears to be relatively rapid. Continued use of this system should allow more effective prevention and limitation of such outbreaks in China. 相似文献102.
103.
Won Hee Lim Bo Liu Du Cheng Daniel J Hunter Zhendong Zhong Daniel M Ramos Bart O Williams Paul T Sharpe Claire Bardet Su‐jung Mah Jill A Helms 《Journal of bone and mineral research》2014,29(4):892-901
Odontoblasts, cementoblasts, ameloblasts, and osteoblasts all form mineralized tissues in the craniofacial complex, and all these cell types exhibit active Wnt signaling during postnatal life. We set out to understand the functions of this Wnt signaling, by evaluating the phenotypes of mice in which the essential Wnt chaperone protein, Wntless was eliminated. The deletion of Wls was restricted to cells expressing Osteocalcin (OCN), which in addition to osteoblasts includes odontoblasts, cementoblasts, and ameloblasts. Dentin, cementum, enamel, and bone all formed in OCN‐Cre;Wlsfl/fl mice but their homeostasis was dramatically affected. The most notable feature was a significant increase in dentin volume and density. We attribute this gain in dentin volume to a Wnt‐mediated misregulation of Runx2. Normally, Wnt signaling stimulates Runx2, which in turn inhibits dentin sialoprotein (DSP); this inhibition must be relieved for odontoblasts to differentiate. In OCN‐Cre;Wlsfl/fl mice, Wnt pathway activation is reduced and Runx2 levels decline. The Runx2‐mediated repression of DSP is relieved and odontoblast differentiation is accordingly enhanced. This study demonstrates the importance of Wnt signaling in the homeostasis of mineralized tissues of the craniofacial complex. © 2014 American Society for Bone and Mineral Research. 相似文献
104.
由于治疗方法的进步,近80%的儿童和青少年癌症患者能够长期生存。在美国,约有270000例儿童癌症的幸存者,即每640名20至39岁成年人中就有一名幸存者。大量的幸存者有利于儿童癌症治疗后长期健康结果的研究。现在可以明确的是,化疗和放疗所致的儿童各器官系统损害在临床上可能潜伏多年。为了全面了解治疗儿童癌症而继发的健康问题,重要的是衡量三项长期结果:健康状况、死亡率和患病率。这三项中,关于前两项已有相当好的研究报道。在一项对20227例癌症5年生存者的回顾性分析中,Mertens等发现以下原因导致的超额死亡率具有统计学意义:继发癌症(… 相似文献
105.
106.
107.
108.
目的探讨经关节入路微创钢板固定(MIPPO)技术治疗股骨远端C型骨折的临床疗效。方法2002年4月~2005年2月,应用MIPPO技术治疗股骨远端C型骨折14例,按AO/ASIF分类:C1型3例,C2型6例,C3型5例。先行关节内骨折切开复位、松质骨螺钉固定,再行髁上部分骨折间接复位、经关节内切口插入髁支撑钢板或LISS钢板桥接固定骨折。结果12例患者获得10~32个月(平均18.4个月)随访,骨折均获愈合,愈合时间10周~12个月,平均4.6个月。按Kolmert和Wulff的评价标准:优4例,良5例,可2例,差1例,优良率为75%。结论应用MIPPO技术治疗股骨远端C型骨折实现了微创操作,具有创伤小、软组织干扰少、骨折愈合快等优点,疗效满意。 相似文献
109.
蔡俊超 《中华移植杂志(电子版)》2010,(4)
随着器官移植体液免疫理论的发展与抗体检测技术的进步,抗体介导的排斥反应(AMR)已逐渐被认识和引起关注。其治疗难度大、逆转率较低,已成为导致移植物失功的重要原因。本文较为系统地介绍了AMR的免疫机制、诊断与防治进展,以及供者特异性抗体的检测技术和临床意义,从而提出供者特异性抗体是引起移植物排斥反应特别是慢性排斥反应的主要原因,移植受者需常规监测抗体以利及时干预和治疗。 相似文献
110.
C Badenas J To-Figueras JD Phillips CA Warby C Muñoz and C Herrero 《Clinical genetics》2009,75(4):346-353
Porphyria cutanea tarda (PCT) arises from decreased hepatic activity of uroporphyrinogen decarboxylase (UROD). Both genetic and environmental factors interplay in the precipitation of clinically overt PCT, but these factors may vary between different geographic areas. Decreased activity of UROD in erythrocytes was used to identify patients with UROD mutations among a group of 130 Spanish PCT patients. Nineteen patients (14.6%) were found to harbor a mutation in the UROD gene. Eight mutations were novel: M1I, 5del10, A22V, D79N, F84I, Q116X, T141I and Y182C. Five others were previously described: F46L, V134Q, R142Q, P150L and E218G. The new missense mutations and P150L were expressed in Escherichia coli. D79N and P150L resulted in proteins that were localized to inclusion bodies. The other mutations produced recombinant proteins that were purified and showed reduced activity (range: 2.3–73.2% of wild type). These single amino acid changes were predicted to produce complex structural alterations and/or reduced stability of the enzyme. Screening of relatives of the probands showed that 37.5% of mutation carriers demonstrated increased urinary porphyrins. This study emphasizes the role of UROD mutations as a strong risk factor for PCT even in areas where environmental factors (hepatitis C virus) have been shown to be highly associated with the disease. 相似文献