全文获取类型
收费全文 | 3855篇 |
免费 | 239篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 84篇 |
妇产科学 | 39篇 |
基础医学 | 521篇 |
口腔科学 | 71篇 |
临床医学 | 303篇 |
内科学 | 827篇 |
皮肤病学 | 128篇 |
神经病学 | 481篇 |
特种医学 | 192篇 |
外科学 | 613篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 230篇 |
眼科学 | 72篇 |
药学 | 228篇 |
中国医学 | 3篇 |
肿瘤学 | 284篇 |
出版年
2023年 | 15篇 |
2022年 | 33篇 |
2021年 | 58篇 |
2020年 | 48篇 |
2019年 | 61篇 |
2018年 | 69篇 |
2017年 | 44篇 |
2016年 | 66篇 |
2015年 | 87篇 |
2014年 | 117篇 |
2013年 | 169篇 |
2012年 | 266篇 |
2011年 | 262篇 |
2010年 | 131篇 |
2009年 | 142篇 |
2008年 | 250篇 |
2007年 | 208篇 |
2006年 | 238篇 |
2005年 | 181篇 |
2004年 | 184篇 |
2003年 | 192篇 |
2002年 | 181篇 |
2001年 | 105篇 |
2000年 | 83篇 |
1999年 | 99篇 |
1998年 | 68篇 |
1997年 | 38篇 |
1996年 | 30篇 |
1995年 | 30篇 |
1994年 | 16篇 |
1993年 | 18篇 |
1992年 | 44篇 |
1991年 | 45篇 |
1990年 | 42篇 |
1989年 | 49篇 |
1988年 | 31篇 |
1987年 | 46篇 |
1986年 | 33篇 |
1985年 | 37篇 |
1984年 | 36篇 |
1983年 | 26篇 |
1981年 | 11篇 |
1980年 | 22篇 |
1979年 | 23篇 |
1978年 | 12篇 |
1977年 | 16篇 |
1976年 | 18篇 |
1975年 | 18篇 |
1969年 | 8篇 |
1966年 | 8篇 |
排序方式: 共有4112条查询结果,搜索用时 15 毫秒
991.
Pahwa R Koller WC Trosch RM Sherry JH;APO Study Investigators 《Journal of the neurological sciences》2007,258(1-2):137-143
OBJECTIVE: To further explore the efficacy and safety of subcutaneous apomorphine (APO) in treating off episodes in APO-na?ve patients with advanced Parkinson's disease (PD). METHODS: 56 patients receiving optimized oral anti-PD medication were evaluated on separate days for response to single increasing doses of APO. Acute response to oral anti-PD medication and APO dose escalation (2-10 mg) was evaluated under unblinded conditions. At the 4 mg APO dose, placebo was randomly introduced under double-blind crossover conditions. RESULTS: Mean changes from pre-dose in Unified Parkinson's Disease Rating Scale motor scores indicated significant improvement following APO 4 mg versus placebo at 20 min (p=0.0002), 40 min (p<0.0001; maximum improvement) and 90 min (p=0.0229). Improvements showed significant dose-response at 20 min, 40 min (both p<0.0001) and 90 min (p=0.0049). Adverse events were more common with APO than placebo, and also showed significant dose-response (p<0.0001). Common adverse events associated with APO included yawning, dizziness, nausea, somnolence and dyskinesias, and were generally mild to moderate. There were no significant differences between APO and placebo in the incidence of hypotension associated with a postural change from a sitting to standing position. CONCLUSIONS: Subcutaneous APO provided rapid, effective relief of off episodes associated with advanced PD. 相似文献
992.
In the last decade, there has been a rapid growth in the presence of clowns in hospitals, particularly in pediatric settings. The proliferation of clowns in health care settings has resulted in varying levels of professionalism and accountability. For this reason, there is a need to examine various forms of clowning, in particular therapeutic clowning in pediatric settings. The purpose of this article is to address what therapeutic clowning is and to describe the extent to which it can provide a complementary form of health care. In an attempt to apply theory to practice, the article will draw upon the experiences of a therapeutic clown within a pediatric setting while providing a historical and theoretical account of how clowns came to be in hospitals. Toward this end, a proposed model of therapeutic clowning will be offered which can be adapted for a variety of settings where children require specialized forms of play in order to enhance their coping, development and adjustment to life changes. Finally, current research on clowning in children's hospitals will be reviewed including a summary of findings from surveys administered at the Hospital for Sick Children. 相似文献
993.
von Eisenhart-Rothe R Müller-Gerbl M Wiedemann E Englmeier KH Graichen H 《Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]》2008,17(5):695-702
We tested the hypothesis that functional malcentering of the humeral head during arm elevation exists in patients with glenohumeral osteoarthritis and influences long-term glenoid loading. Twenty-eight healthy volunteers and 10 patients with primary osteoarthritis, 10 with cuff-arthropathy, and 1 with dysplastic glenoid were examined. Open magnetic resonance imaging and 3-dimensional (3D) digital postprocessing techniques were applied in various arm positions. Osteoabsorptiometry was used to determine 3D subchondral mineralization patterns of the glenoid as an indicator of integral long-term stress distribution. At 30 degrees of abduction, 5 patients demonstrated malcentering of the humeral head posteriorly; all patients with cuff arthropathy had malcentering superiorly. At 90 degrees, most patients displayed significant (P < .001) malcentering in the superior and posterior direction. The shoulders showed maximal subchondral mineralization patterns in the direction of malcentering. Most patients with glenohumeral osteoarthritis displayed functional malcentering, which might be responsible for postoperative glenoid loosening in shoulder arthroplasty if not corrected intraoperatively. 相似文献
994.
Kolb K Koller H Holz U Kolb W Windisch C Markgraf E Grützner PA 《Der Unfallchirurg》2008,111(5):299-307
BACKGROUND: The incidence of relevant posttraumatic functional deficits in the sense of elbow stiffness with less than 30 degrees in extension or flexion less than 120 degrees , is unknown. A differentiation can be made between intraarticular, extraarticular and combined causes. An open procedure is indicated in elbow stiffness after correct analysis of the situation and failure of conservative treatment. MATERIALS AND METHODS: An open procedure was carried out on 35 patients between March 1995 and November 2001, 10 (3-24) months after the trauma. The mean age of the 24 men and 11 women was 45 (range 17-75) years. Of the patients 15 had distal humerus fractures, 10 radius head or neck fractures and 12 proximal ulnar fractures. RESULTS: Of the patients 11 (31%) had an excellent result in the Cauchoix and Deburge score, 15 (42%) a good, 4 (11%) a fair, 4 (11%) a bad and 1 (3%) a very bad result after a mean follow-up of 21.5 (range 9-60) months. Of the patients 11 (31%) had an excellent result in the Mayo elbow performance score, 14 (40%) a good, 5 (14%) a fair and 5 (14%) a poor result. CONCLUSION: Open arthrolysis for severe posttraumatic elbow stiffness carried out 10 months (range 3-24 months) after the accident led to good results in most cases with a clear improvement in functional mobility. 相似文献
995.
996.
997.
Background
Studies on health inequalities still focus mostly on adults. Research about social disparities and health in children is slowly increasing, also in Germany, but these studies are mostly restricted to individual social variables derived from the parents to determine social class. This paper analyses the data of the medical check-up prior to school enrolment to determine differences concerning overweight, participation in health check-ups and immunization; it includes individual social variables but also regional variables describing the social environment of the children. 相似文献998.
Development of neurodegenerative diseases such as Alzheimer's and Parkinson's disease is strongly age-associated. The impairment of calcium homeostasis is considered to be a key pathological event leading to neuronal dysfunction and cell death. However, the exact impact of aging on calcium homeostasis in neurons remains largely unknown. In the present work we have investigated intracellular calcium levels in cultured primary hippocampal neurons from young (2 months) and aged (24 months) rat brains. Upon stimulation with glutamate or hydrogen peroxide aged neurons in comparison to young neurons demonstrated an increased vulnerability to these disease-related toxins. Measurement of calpain activity using Western blot analysis showed a significant increase in basal activity of calpains in aged neurons. The observed increase of calpain activity was correlated with elevated protein levels of μ-calpain. Ca2+-imaging experiments performed on living individual neurons using the dye calcium green demonstrated a twofold increase in intracellular calcium concentration in aged neurons as compared to young neurons. The observed changes of intracellular calcium in aged neurons might play a role in their increased vulnerability to neurodegeneration. 相似文献
999.
Stolte M Müller H Talley NJ O'morain C Bolling-Sternevald E Sundin M Eriksson S Blum A 《Pathology, research and practice》2006,202(6):405-413
The aim of this study was to assess whether the taking of an additional biopsy from the incisura angularis increases the chance of detecting maximal degrees of atrophy and intestinal metaplasia (IM) in patients with Helicobacter pylori gastritis and functional dyspepsia. At entry into a randomised trial, biopsies were taken from 328 patients (mean age 48 years), two from both the gastric antrum and corpus, and one from the incisura angularis, and comparative grading of gastritis variables was carried out. Biopsy material from the gastric antrum, corpus, and the incisura angularis revealed no notable differences in atrophy or an incidence of IM and mucosa-associated lymphatic tissue. However, when the incisura biopsies were classified histologically, 58% contained antral mucosa (AM), 18% corpus mucosa (CM), and 24% intermediate zone mucosa. AM at the incisura was associated with considerably more severe gastritis in both the incisura and antrum (14% atrophy, 20% IM) than in CM of incisura (2% atrophy, 6% IM). Corpus atrophy and IM were rare in the AM group and absent from the CM group. Incisura angularis biopsy in patients with H. pylori gastritis and functional dyspepsia does give additional information regarding the severity of gastritis expected in the corpus and antrum. Antral-type mucosa in the incisura angularis region seems to indicate an increased risk for the development of atrophy and/or IM. 相似文献
1000.