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Pulmonary vascular cine MR imaging: a noninvasive approach to dynamic imaging of the pulmonary circulation 总被引:1,自引:0,他引:1
W B Gefter H Hatabu B J Dinsmore L Axel H I Palevsky N Reichek M L Schiebler H Y Kressel 《Radiology》1990,176(3):761-770
Cine gradient-recalled magnetic resonance (MR) imaging, which has flow sensitivity and high temporal resolution, may potentially yield both morphologic and dynamic flow-related information in the pulmonary vasculature. The authors used this modality to evaluate pulmonary vessels in 12 healthy subjects and in 14 patients with a variety of cardiopulmonary disorders. Normal pulmonary arteries and veins were characterized by distinctive signal intensity and diameter variations as well as motion of the vessels during the cardiac cycle. Patients with pulmonary arterial hypertension demonstrated loss of the normal pulsatile systolic increase and diastolic decline in velocity-related signal intensity and in diameter of the proximal pulmonary arteries. Disorders of pulmonary venous signal and diameter profiles during the cardiac cycle, which show a characteristic biphasic pattern in healthy subjects, were identified in five patients with mitral valvular disease. These initial results indicate that cine MR imaging techniques hold promise in the evaluation of pathophysiologic conditions in the pulmonary circulation. 相似文献
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Risk of recurrent venous thromboembolism and major hemorrhage in cancer‐associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients
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T. van der Hulle P. L. den Exter B. Planquette G. Meyer S. Soler M. Monreal D. Jiménez A. K. Portillo C. O'Connell H. A. Liebman M. Shteinberg Y. Adir M. Tiseo M. Bersanelli H. N. Abdel‐Razeq A. H. Mansour O. G. Donnelly G. Radhakrishna S. Ramasamy G. Bozas A. Maraveyas A. B. Shinagare H. Hatabu M. Nishino M. V. Huisman F. A. Klok 《Journal of thrombosis and haemostasis》2016,14(1):105-113
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Uematsu H Takahashi M Hatabu H Chin CL Wehrli SL Wehrli FW Asakura T 《Journal of computer assisted tomography》2007,31(5):662-665
OBJECTIVE: The aim of this study was to clarify the relative contributions of the amount of oxygen in the blood, and vasoconstriction/dilation responsible for changes in T1 and T2 observed in brain during hyperoxia. METHODS: T1 and T2 values of the cerebral cortex and pituitary gland in mice were determined in room air. After room air was changed to either 100% oxygen (n = 8) or carbogen (n = 8), T1 and T2 values were again determined. Changes in each value with both gases were compared. RESULTS: In both challenges, T1 values of the cerebral cortex decreased, whereas significant T2 prolongation of the cerebral cortex and pituitary gland was demonstrated. However, both cortex and pituitary gland displayed similar responses in T1 and T2 values when exposed to 100% oxygen or carbogen. CONCLUSIONS: Reduction of T1 was introduced by the increased amount of dissolved oxygen in blood, and the increased fraction of oxyhemoglobin caused T2 prolongation. The contribution of vasoconstriction/dilation by carbogen to changes in T1 and T2 may be negligible. 相似文献
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Kino A Takahashi M Ashiku SK Decamp MM Lenkinski RE Hatabu H 《European journal of radiology》2007,64(3):397-400
The purpose of this study was to evaluate optimal breathing maneuvers that minimize lung parenchymal movement for dynamic contrast-enhanced MRI (DCE-MRI), which requires longer scan times, beyond the limit of a single breath hold. A healthy volunteer was scanned on a 3T MR scanner using two different breathing maneuvers. In the first, the healthy volunteer was instructed to hold his breath as much as possible and breathe in between breath holds while an image was obtained. In the second, the volunteer was instructed to breathe shallowly and freely throughout the scan. On the obtained images, the excursion of the highest point of the right diaphragm and the pulmonary vessel branches located in the four different anatomic regions of the lung were measured in two orthogonal planes. A patient with a solitary pulmonary nodule (SPN) underwent DCE-MRI utilizing a 2D spoiled gradient-echo (SPGR) sequence while the patient breathed shallowly and freely during the scan. The standard deviations of the excursion of the highest point and selected pulmonary vessels were much smaller during shallow, free breathing maneuver scans than those during breath hold maneuver scans. A dynamic perfusion-fitting curve of the SPN was obtained during the DCE-MRI using shallow free breathing. Shallow, free breathing allows smaller diaphragmatic cranial caudal and lung parenchymal displacements. Therefore, it can be useful during exams where targeting of the lesion is necessary, in studies with long scan times, such as dynamic MRI. This breathing maneuver makes it possible to analyze SPN with DCE-MRI while making use of the advantages of a higher magnetic field in conjunction. 相似文献
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Matsuoka S Hunsaker AR Gill RR Jacobson FL Ohno Y Patz S Hatabu H 《Magnetic Resonance Imaging Clinics of North America》2008,16(2):275-89, ix
Recent development of MR techniques has overcome many problems, such as susceptibility artifacts or motion artifact, allowing both static and dynamic MR lung imaging and providing quantitative information of pulmonary function, including perfusion, ventilation, and respiratory motion. Dynamic contrast-enhanced MR perfusion imaging is suitable for the evaluation of angiogenesis of pulmonary solitary nodules. (129)Xe MR imaging is potentially a robust technique for the evaluation of various pulmonary function and may replace (3)He. The information provided by these new MR imaging methods is proving useful in research and in clinical applications in various lung diseases. 相似文献
29.
Warren B. Gefter Hiroto Hatabu George A. Holland Andrew W. Osiason 《Seminars in Ultrasound, CT and MRI》1996,17(4):316-323
Recent technical improvements have made pulmonary MR angiography (MRA) feasible. The technique is attractive because it is noninvasive, provides a full three-dimensional (3D) display of the pulmonary vasculature, and potentially can be combined with MR venography of the lower extremities and pelvis for the comprehensive diagnosis of thromboembolism. Approaches to acquiring pulmonary MR angiograms are currently being developed and include both two-dimensional and 3D time-of-flight methods, breath-hold and non-breath-hold techniques, and the use of gadolinium-based contrast enhancement. The results of initial studies using pulmonary MRA for the detection of pulmonary embolism are encouraging, but they must be evaluated in conjunction with newly developed fast CT scanning techniques. This article reviews the state of development of pulmonary MRA, the current clinical applications of the technique, and the prospects for future development. 相似文献
30.
Hiroto Hatabu 《Seminars in Ultrasound, CT and MRI》1997,18(5):349-361
Recent advances in MR pulmonary angiography and MR perfusion imaging are reviewed, focusing on two principal areas of technical development: (1) the availability of MR scanners equipped with enhanced gradient systems; and (2) new trends in MR angiography using gadolinium contrast agents or labeling of blood with an inversion recovery radiofrequency pulse in place of the more traditional methods using naturally flowing spins as the source of intravascular signal. These recent developments in MR have significant potential for clinical imaging of the pulmonary vasculature, particularly for the diagnosis of pulmonary embolism, and are now opening windows to functional MR imaging of the lung. 相似文献