全文获取类型
收费全文 | 1155篇 |
免费 | 45篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 15篇 |
基础医学 | 214篇 |
口腔科学 | 6篇 |
临床医学 | 55篇 |
内科学 | 142篇 |
皮肤病学 | 53篇 |
神经病学 | 345篇 |
特种医学 | 40篇 |
外科学 | 99篇 |
综合类 | 3篇 |
预防医学 | 46篇 |
眼科学 | 9篇 |
药学 | 99篇 |
肿瘤学 | 45篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 9篇 |
2019年 | 12篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 12篇 |
2015年 | 19篇 |
2014年 | 19篇 |
2013年 | 24篇 |
2012年 | 40篇 |
2011年 | 33篇 |
2010年 | 21篇 |
2009年 | 20篇 |
2008年 | 44篇 |
2007年 | 50篇 |
2006年 | 55篇 |
2005年 | 57篇 |
2004年 | 42篇 |
2003年 | 58篇 |
2002年 | 58篇 |
2001年 | 31篇 |
2000年 | 37篇 |
1999年 | 21篇 |
1998年 | 12篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 7篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 30篇 |
1991年 | 41篇 |
1990年 | 44篇 |
1989年 | 49篇 |
1988年 | 36篇 |
1987年 | 33篇 |
1986年 | 35篇 |
1985年 | 46篇 |
1984年 | 36篇 |
1983年 | 24篇 |
1982年 | 20篇 |
1981年 | 17篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 4篇 |
排序方式: 共有1201条查询结果,搜索用时 0 毫秒
991.
The distribution of vasoactive intestinal polypeptide (VIP)-like immunoreactive structures in the rat spinal cord and their projections were investigated by means of an immunofluorescent method. In the normal rat, a small number of VIP-positive fibers were observed in the superficial layer of the dorsal horn and in the lateral funiculus. With colchicine pretreatment, VIP-positive neurons were demonstrated in the lateral spinal nucleus (lsn) and in the lamina X (Rexed). Transections of the spinal cord at various levels revealed that some of the VIP neurons in the lsn might project to supraspinal areas via lateral funiculus. 相似文献
992.
Isthmus organizer for midbrain and hindbrain development 总被引:2,自引:0,他引:2
993.
Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice. 总被引:2,自引:0,他引:2
H Fujimaki K Nohara T Kobayashi K Suzuki K Eguchi-Kasai S Tsukumo M Kijima C Tohyama 《Toxicological sciences》2002,66(1):117-124
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces immunosuppression in humans and animals. However, the effect of TCDD on Th2-type immune responses such as allergic reactions has been unclear. Using NC/Nga mice that developed atopic dermatitis-like skin lesions with marked elevation in plasma of total IgE when bred under conventional conditions, we investigated the effects of a single oral dose of TCDD on immune responses. NC/Nga mice received a single oral dose (0 or 20 microg/kg body weight) of TCDD. On day 7, treatment with TCDD alone decreased the cellularity of thymus. However, treatment with TCDD modified the cellularity of spleens and mesenteric lymph nodes (MLNs) but not of the thymus on day 28. When NC/Nga mice received ip immunization with OVA and alum on the same day as the TCDD treatment (0, 5, or 20 microg/kg body weight), TCDD markedly suppressed the concentrations of Th2-type cytokines (e.g., IL-4 and IL-5) in culture supernatants of spleen cells, whereas IFN-gamma production significantly increased. TCDD exposure reduced anti-OVA and total IgE antibody titers in plasma and did not induce the development of atopic dermatitis-like lesions in the pinnae or dorsal skin of NC/Nga mice. These results suggest that in NC/Nga mice, exposure to TCDD may impair the induction of Th2-type immune responses. 相似文献
994.
John Q. Trojanowski Kar-Ming Fung Lucy B. Rorke Takashi Tohyama Anthony T. Yachnis Virginia M. -Y. Lee 《Journal of molecular neuroscience : MN》2003,21(2-3):219-239
Recent advances in understanding the basic biology of the neoplastic cells that populate childhood primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) underline several unique properties of these common pediatric brain neoplasms. For example, studies of posterior fossa cerebellar medulloblastomas (MB), a prototypical group of brain tumors that comprise the largest class of PNET, suggest that the molecular phenotype of subpopulations of neoplastic cells in MB partially recapitulates stages in the acquisition of the neuronal phenotype by normal developing human CNS progenitor cells. However, as reviewed here, it appears that the neoplastic cells in MB exhibit one or more molecular defects in the sequence of normal maturational events that enable CNS progenitor cells to exit the cell cycle, become committed to the neuronal lineage, and undergo terminal differentiation into fully mature, permanently postmitotic CNS neurons. Indeed, since PNET emerge almost exclusively in early childhood, the induction of PNET may result from genetic lesions that arise in developing CNS progenitor cells thereby preventing these neural precursors from executing normal programs of lineage commitment and differentiation in the CNS. Clarification of how lineage commitment and maturation in PNET comprised of neuron-like tumor cells deviate from normal CNS development may clarify how oncogenes and tumor suppressor genes exert their effects in a cell type specific manner at different stages in the normal maturation of CNS cells. Recently, a number of potentially effective in vitro and in vivo model systems of PNET have been developed. Since these model systems could facilitate efforts to elucidate mechanisms of neoplastic transformation and tumor progression in the CNS, we review, the potential utility of several recently described in vitro (e.g., MB cell lines) and in vivo (e.g., transgenic mice) experimental systems as models of authentic childhood CNS neoplasms. 相似文献
995.
We report a rare case of trigger finger caused by an old partial laceration of the flexor digitorum superficialis. The triggering occurred five months after injury. This case was the latest presentation of triggering in the literature. The patient was managed by incising the A1 pulley and suturing the flexor tendon flap after trimming. He was relieved of triggering and there was no recurrence. 相似文献
996.
997.
A 16q12.2q21 deletion identified in a patient with developmental delay,epilepsy, short stature,and distinctive features 下载免费PDF全文
Toshiyuki Yamamoto Keiko Shimojima Sawako Yamazaki Kanju Ikeno Jun Tohyama 《Congenital anomalies》2016,56(6):253-255
Interstitial deletions of the 16q centromeric region are rarely reported. A microdeletion of the 16q12.2q21 region was identified in a patient with intellectual disability, epilepsy, short stature, and distinctive features; including up‐slanting palpebral fissures, hypertelorism, epicanthic folds, anteverted nares, simple philtrum, thin upper lip vermilion, high arched palate, posteriorly rotated ears, and overlapping toes in his right foot. Although the deleted region includes the genes responsible for neurological impairments (GNOA1, GPR56, KATNB1, and BBS2), haploinsufficiency of these genes would not be associated with the patient's phenotype. When NDRG4, present in the deleted region, was knocked out in mice, these mice exhibited spatial learning deficits. Thus, we hypothesize that this gene could be a potential candidate underlying the neurological observations of the patient. Because RSPRY1 was been discovered as the cause of progressive skeletal dysplasia, a loss of this gene might explain the skeletal defects observed in the patient. 相似文献
998.
Kai Ishida Manami Sawa Kousaku Fujiwara Minoru Hirose Harukazu Tsuruta Akihiro Takeuchi Noriaki Ikeda 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2013,17(1):65-71
The Great East Japan Earthquake on 11 March 2011 caused major damage in northeastern Japan. The Kanto region experienced a massive electrical power shortage in the summer of 2011. A questionnaire was submitted to 354 hemodialysis clinics in Kanagawa prefecture and the Tokyo metropolitan area, excluding isolated islands, and 176 responses were analyzed (49.7%). The questions included evaluation of the availability of a private electricity generator, countermeasures in case of a planned outage, awareness of saving electricity, and improvement of safety of medical devices or electrical facilities after the earthquake. Only 12% of the clinics had private electricity generators and many clinics had no plans to introduce this facility. However, 96% of the clinics had established countermeasures to deal with a planned outage. Many clinics planned to provide dialysis on a different day or at a different time. All clinics had tried hard to establish procedures to save electricity in the summer of 2011, and 84% of the clinics had reconsidered and improved the safety of medical devices or electricity facilities after the earthquake. These results show that the awareness of crisis management was greatly improved in the wake of the earthquake. 相似文献
999.
1000.
Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures 总被引:1,自引:0,他引:1
Ichiyama T Suenaga N Kajimoto M Tohyama J Isumi H Kubota M Mori M Furukawa S 《Brain & development》2008,30(1):47-52
It is well known that an acute encephalopathy occasionally follows prolonged febrile seizures. We measured the concentrations of interferon-gamma, tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in serum and CSF during the acute stage in 13 children with acute encephalopathy following prolonged febrile seizures (AEPFS) and 23 with prolonged febrile seizures without encephalopathy (PFS) to investigate the pathogenesis of AEPFS. Serum IL-6, IL-10, sTNFR1, and CSF IL-6 levels were significantly higher in AEPFS and PFS compared with control subjects. CSF IL-6 levels in AEPFS were significantly higher than those in PFS, but not serum IL-6, IL-10, or sTNFR1. The CSF IL-6 levels were significantly higher than the serum levels in AEPFS, but not PFS. The serum levels of sTNFR1 and IL-10 were significantly higher than those in the CSF in AEPFS and PFS. The serum IL-10 and sTNFR1 levels in patients who did not experience a second seizure were significantly higher than those in patients who experienced a second seizure, which was characterized by clusters of complex partial seizures several days after the initial prolonged febrile seizure. Our results suggest that serum IL-6, IL-10, TNF-alpha, and CSF IL-6 are part of the regulatory system of cytokines in AEPFS. 相似文献