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991.
992.
Prof. Dr. M. Goldschmidt 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1924,113(1-2):160-185
Ohne Zusammenfassung 相似文献
993.
Dr. R. Goldschmidt 《Journal of cancer research and clinical oncology》1908,7(1):111-125
Ohne ZusammenfassungHerrn Professor Ehrmann spreche ich auch an dieser Stelle für die mir gewordene Anregung und Unterstützung meinen herzlichsten Dank aus. 相似文献
994.
P H Petersen S Sandberg C G Fraser H Goldschmidt 《Clinical chemistry and laboratory medicine》2001,39(2):160-165
The index of individuality is defined as the ratio of the within-subject biological variation to the between-subject variation, i.e., the variation between the biological set-points. It has been disputed whether the index of individuality has influence on the usefulness of conventional population-based reference intervals. In this investigation we found that, as long as only a single sample is taken, for a certain change in an individual's set-point, the index of individuality has no influence on the usefulness of reference intervals. When two or more samples are taken into account, however, the outcome of the measurement is highly dependent on the index of individuality. For a low index, repeat measurement has only limited effect on the fraction of false-positive results, as the next result will be close to the first, but, when the index is high, the fraction of false-positive results will be reduced considerably through repeating the test. Moreover, the distribution of biological set-points for which the fraction of false-positive results originate is described and the influence of analytical imprecision is discussed. The calculations are performed for values of the index of individuality from 0 to 2.0 for the traditional 95% reference interval based on x +/- 2*s(total) (s(total) = total biological variation), and also for a decision limit (cut-off point) x +/- 3*s(total). The numbers are, of course, different, but the effects of the index of individuality are the same, independent of the chosen cut-off point. This concept is related to the clinical classification (diagnosis, prognosis, screening) and the difference from different principles of monitoring is discussed. Further, five examples are evaluated and aspects of index of individuality in relation to false-positive results are discussed. 相似文献
995.
996.
997.
Focal Loss of CD44 Variant Protein Expression is Related to Recurrence in Superficial Bladder Carcinoma 总被引:5,自引:0,他引:5 下载免费PDF全文
Valeriu Toma Dieter Hauri Ulrico Schmid Daniel Ackermann Robert Maurer Gran Alund Hartmut Knnagel Marcus Rist Thomas C. Gasser Guido Sauter Jürgen Roth 《The American journal of pathology》1999,155(5):1427-1432
The majority of papillary transitional cell carcinomas of the bladder are localized tumors at initial diagnosis; identification of those developing recurrence and an aggressive behavior is important. CD44 variant proteins have been implicated in tumor progression and metastasis, and a correlation with adverse prognosis has been demonstrated in a variety of human tumors. Here, the usefulness of conventional CD44 protein immunohistochemistry as a prognostic parameter for recurrence of superficial transitional cell carcinomas was assessed in paraffin sections of 241 tumors with long-term follow-up. A highly significant association was found between focal loss of CD44v3 and -v6 immunostaining and short recurrence-free interval in noninvasive (pTa) transitional cell carcinomas (P = 0.005), but not in minimally invasive (pT1) carcinomas (P = 0.78). Our results indicate the value of conventional CD44 immunohistochemistry as an additional tool for identifying patients at high risk for recurrence of pTa transitional cell carcinomas. They also point to biological differences between noninvasive and minimally invasive transitional cell carcinomas of the bladder. 相似文献
998.
999.
Falk-Udo Sack Arnt Kristen Hartmut Goldschmidt Philipp A Schnabel Thomas Dengler Achim Koch Matthias Karck 《European journal of cardio-thoracic surgery》2008,33(2):257-262
OBJECTIVE: Cardiac amyloidosis (CA) is associated with a poor prognosis and a survival rate of less than 30% 2 years after clinical manifestation. Considered as a semi-malignant disease, CA is often a contraindication for HTx; however, depending on the type of CA, there are excellent treatment regimes that can be combined with HTx. In AL-amyloidosis, chemotherapy and stem cell transplantation are necessary and in TTR-amyloidosis, where the liver is the source of the pathologic protein, liver transplantation is recommended after HTx. METHODS AND RESULTS: More than 60 patients with AL-amyloidosis and more than 25 patients with ATTR-amyloidosis have been investigated at our centre. Eighteen patients showed signs of end-stage heart failure. Four patients died within 1 month after listing for HTx. Seven patients with AL (mean age 41.8 years) and five patients with ATTR-amyloidosis (mean age 42.6 years) were successfully transplanted with an actual survival rate of 91.6%. One patient died 8 months after HTx due to infection. Five AL patients received chemotherapy and SCT and one ATTR patient was liver transplanted. Three AL patients showed complete remission of amyloidosis. CONCLUSIONS: Cardiac amyloidosis is a potentially curative disease after HTx when combined with either chemotherapy and SCT or LiverTx depending on the type of the amyloidosis. Due to the natural course of the disease, urgent HTx after cardiac manifestation is mandatory. With this approach, excellent survival rates and even remission of the underlying disease is possible. 相似文献
1000.
Prof. Dr. M. Goldschmidt 《Journal of molecular medicine (Berlin, Germany)》1927,6(14):635-637
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