全文获取类型
收费全文 | 5638篇 |
免费 | 499篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 212篇 |
妇产科学 | 206篇 |
基础医学 | 783篇 |
口腔科学 | 61篇 |
临床医学 | 554篇 |
内科学 | 1119篇 |
皮肤病学 | 68篇 |
神经病学 | 692篇 |
特种医学 | 98篇 |
外科学 | 510篇 |
综合类 | 63篇 |
一般理论 | 9篇 |
预防医学 | 801篇 |
眼科学 | 142篇 |
药学 | 345篇 |
中国医学 | 6篇 |
肿瘤学 | 422篇 |
出版年
2024年 | 17篇 |
2023年 | 159篇 |
2022年 | 201篇 |
2021年 | 503篇 |
2020年 | 274篇 |
2019年 | 335篇 |
2018年 | 310篇 |
2017年 | 217篇 |
2016年 | 228篇 |
2015年 | 243篇 |
2014年 | 284篇 |
2013年 | 332篇 |
2012年 | 476篇 |
2011年 | 389篇 |
2010年 | 199篇 |
2009年 | 153篇 |
2008年 | 254篇 |
2007年 | 291篇 |
2006年 | 229篇 |
2005年 | 202篇 |
2004年 | 171篇 |
2003年 | 136篇 |
2002年 | 114篇 |
2001年 | 29篇 |
2000年 | 19篇 |
1999年 | 31篇 |
1998年 | 25篇 |
1997年 | 19篇 |
1996年 | 20篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 14篇 |
1991年 | 23篇 |
1990年 | 13篇 |
1989年 | 12篇 |
1988年 | 17篇 |
1987年 | 20篇 |
1986年 | 9篇 |
1985年 | 16篇 |
1984年 | 7篇 |
1982年 | 8篇 |
1980年 | 9篇 |
1977年 | 7篇 |
1976年 | 9篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1972年 | 7篇 |
1969年 | 6篇 |
1968年 | 7篇 |
排序方式: 共有6144条查询结果,搜索用时 257 毫秒
991.
992.
Jacqueline Naylor Aisling Minard Hannah J Gaunt Mohamed S Amer Lesley A Wilson Marco Migliore Sin Y Cheung Hussein N Rubaiy Nicola M Blythe Katie E Musialowski Melanie J Ludlow William D Evans Ben L Green Hongjun Yang Yun You Jing Li Colin W?G Fishwick Katsuhiko Muraki David J Beech Robin S Bon 《British journal of pharmacology》2016,173(3):562-574
Background and Purpose
The TRPC5 proteins assemble to create calcium‐permeable, non‐selective, cationic channels. We sought novel modulators of these channels through studies of natural products.Experimental Approach
Intracellular calcium measurements and patch clamp recordings were made from cell lines. Compounds were generated by synthetic chemistry.Key Results
Through a screen of natural products used in traditional Chinese medicines, the flavonol galangin was identified as an inhibitor of lanthanide‐evoked calcium entry in TRPC5 overexpressing HEK 293 cells (IC50 0.45 μM). Galangin also inhibited lanthanide‐evoked TRPC5‐mediated current in whole‐cell and outside‐out patch recordings. In differentiated 3T3‐L1 cells, it inhibited constitutive and lanthanide‐evoked calcium entry through endogenous TRPC5‐containing channels. The related natural flavonols, kaempferol and quercetin were less potent inhibitors of TRPC5. Myricetin and luteolin lacked effect, and apigenin was a stimulator. Based on structure–activity relationship studies with natural and synthetic flavonols, we designed 3,5,7‐trihydroxy‐2‐(2‐bromophenyl)‐4H‐chromen‐4‐one (AM12), which inhibited lanthanide‐evoked TRPC5 activity with an IC50 of 0.28 μM. AM12 also inhibited TRPC5 activity evoked by the agonist (−)‐Englerin A and was effective in excised outside‐out membrane patches, suggesting a relatively direct effect. It inhibited TRPC4 channels similarly, but its inhibitory effect on TRPC1–TRPC5 heteromeric channels was weaker.Conclusions and Implications
The data suggest that galangin (a natural product from the ginger family) is a TRPC5 inhibitor and that other natural and synthetic flavonoids contain antagonist or agonist capabilities at TRPC5 and closely related channels depending on the substitution patterns of both the chromone core and the phenyl ring.Abbreviations
- LPC
- lysophosphatidylcholine
- S1P
- sphingosine 1‐phosphate
993.
994.
995.
996.
997.
Paul C. Turner Jessica Brayley Hannah C. Downing Gareth J. Homfray Georgia Doolan Siba P. Paul 《Journal of medical virology》2019,91(10):1882-1886
Enteroviral meningitis in infants and children commonly leads to hospital admission. Diagnosing viral meningitis can be difficult clinically. We examined the usefulness of enteroviral polymerase chain reaction (PCR) testing using cerebrospinal fluid (CSF) samples on clinical practice by comparing positive enteroviral CSF PCR cases (n = 39/136) to negative controls using both clinical outcomes and laboratory parameters. A positive result correlated with a reduced admission to high dependency unit, reduced the duration of antibiotics and a shorter length of stay (P < .05). Adjusted CSF white cell count > 5/μL correlated with positive PCR (P < .05) but would have missed 32% of cases of enteroviral meningitis. Following these findings, an algorithm for the management of suspected viral meningitis has been introduced. 相似文献
998.
Jessica L. Borelli Dana Shai Patricia A. Smiley Sameen Boparai Alison Goldstein Hannah F. Rasmussen Douglas A. Granger 《Developmental psychobiology》2019,61(8):1120-1134
An increasing amount of empirical attention is focused on adrenocortical synchrony as an index of biobehavioral co-regulation between parent and child in the context of early child development. Working with an ethnically diverse community sample of children (N = 99, 50.5% male, ages 9–12), we collected saliva samples from mother–child dyads prior to and after a laboratory-based performance challenge task, and tested whether maternal overcontrol and child age moderated dyadic synchrony in cortisol. Results revealed that cortisol levels between mothers and children were significantly positively correlated at pretask for dyads with mean age and older children only, at 25-min post-task for all dyads, and at 45-min post-task for all dyads. Higher overcontrol/older child dyads exhibited a unique pattern of cortisol synchrony wherein at pretask, mother–child levels had the strongest positive correlation, whereas at 25 and 45 min, mother–child cortisol levels were significantly inversely correlated. These findings contribute to theory and research on parent–child relationships by examining parenting behavior, developmental stage, and adrenocortical synchrony in tandem. 相似文献
999.
Reout Arbel Hannah L. Schacter Sohyun C. Han Adela C. Timmons Lauren Spies Shapiro Gayla Margolin 《Developmental psychobiology》2019,61(6):930-941
This study investigates bidirectional associations between adolescents’ daily experiences of victimization and aggression perpetration within friendships. We investigated (a) across-day associations between victimization and aggression perpetration; (b) morning cortisol activity as a moderator of cross-day victimization and aggression links; and (c) potential sex differences in these patterns. For 4 consecutive days, 99 adolescents (Mage = 18.06, SD = 1.09, 46 females) reported whether they were victimized by or aggressive toward their friends. On three of these days, adolescents provided three morning saliva samples. Multilevel path analyses showed that across days, victimization and aggression were bidirectionally linked, but only for male adolescents. Additionally, for male adolescents, morning cortisol output (but not morning cortisol increase) moderated the association between victimization and next-day aggression; victimization predicted greater next-day aggression for boys with low, but not high, morning cortisol output. Findings implicate a physiological factor that may modify daily links between victimization and aggression in male adolescent friendships. 相似文献
1000.
Valerie M. Corrigall Mark D. Bodman‐Smith Melanie Brunst Hannah Cornell Gabriel S. Panayi 《Arthritis \u0026amp; Rheumatology》2004,50(4):1164-1171