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991.
Lung resistance-related protein (LRP) was identified as the major vault protein (MVP), the main component of multimeric vault
particles. It functions as a transport-associated protein that can be associated with multidrug resistance. In previous studies,
expression of MVP/LRP has been documented in tumors of various types. In general, good correlations have been reported for
expression of MVP/LRP and decreased sensitivity to chemotherapy and poor prognosis. MVP/LRP expression has been documented
in glioblastomas, but its expression in nervous system tumors in general has not been well characterized. Immunohistochemistry
using anti-human MVP/LRP antibody (LRP-56) was performed on formalin-fixed, paraffin-embedded archival tissue from 69 primary
central nervous system tumors. Expression of MVP/LRP was observed in 81.2% (56/69) of primary nervous system tumors, including
astrocytomas (11/13), oligodendrogliomas (1/2), oligoastrocytomas (5/5), ependymoma (1/1), meningiomas (35/45), schwannomas
(2/2), and neurofibroma (1/1). Various degrees and distributions of immunoreactivity to MVP/LRP were observed. Neither the
presence nor the degree of immunoreactivity to MVP/LRP showed any correlation with either tumor grade or the presence of brain
invasion. 相似文献
992.
Eating behavior after gastric bypass surgery for obesity 总被引:1,自引:0,他引:1
We studied eating behavior in two non-overlapping cohorts of consecutive patients electing gastric bypass surgery for obesity: 100 patients one year after operation and 60 patients three years afterward. Information was obtained through structured interviews and from office charts. Eating behavior was compared with previously collected data on 232 morbidly obese adults and 174 adults of normal weight. Despite an average weight loss of 100 lb (45 kg), there was little evidence of disturbed eating patterns among gastric bypass patients. Significantly fewer gastric bypass patients than morbidly obese comparison subjects reported frequent hunger, overeating, guilt about eating, or food preoccupation. Gastric bypass patients reported less preoccupation with food than did the normal-weight comparison subjects. 相似文献
993.
Ch Frangides MD NG Kounis MD PJ Papadaki MD J Goudevenos MD GM Zavras MD 《International journal of clinical practice》1995,49(4):215-216
SUMMARY The first documented case of massive hepatic haemangiomatosis to present in an elderly patient (who survived to the age of 82). 相似文献
994.
Use of pelvic ultrasound to monitor ovarian and uterine maturity in childhood onset anorexia nervosa
KY Lai R de Bruyn B Lask R Bryant-Waugh M Hankins 《Archives of disease in childhood》1994,71(3):228-231
This study reports the use of pelvic ultrasound scanning in childhood onset anorexia nervosa. The aim was to determine the weight and weight for height ratio (wt/ht) that would correspond with ovarian and uterine maturity and therefore offer the optimal opportunity for the start or resumption of menstruation. On initial assessment, all children had mean weight, wt/ht, ovarian and uterine volumes significantly below expected. At follow up, half the children had started or resumed menstruation. When compared with those who had persisting amenorrhoea, the recovered children had a significantly higher mean weight (48.4 kg v 43.8 kg), mean wt/ht (96.5% v 87.5%), mean ovarian volume (6.2 ml v 4.9 ml), and mean uterine volume (14.6 ml v 10.8 ml). The study indicates that conventional target weight and wt/ht in anorexia nervosa may be too low to ensure ovarian and uterine maturity, and that pelvic ultrasound, which is well tolerated by this group of children, is a useful addition to their management. 相似文献
995.
The abnormal bone scan in intracranial lesions 总被引:3,自引:0,他引:3
996.
997.
Chemical shift-based true water and fat images: regional phase correction of modified spin-echo MR images 总被引:1,自引:0,他引:1
The process of separating water and fat signal in magnetic resonance images with the Dixon pulse sequence is hindered by phase errors in the water-fat opposed image. These errors arise from static field inhomogeneities, varying magnetic susceptibilities of different body tissues, and other causes. Phase correction performed with data from phantom imaging can compensate for static field inhomogeneities but not for the other effects. A regional phase-correction algorithm is presented that removes non-chemical-shift phase effects and produces true water and fat images. The technique has been applied with good results to 21 patients and healthy volunteers. The images include ones of the abdomen, knees, hips, spine, and head. This method of regional phase correction is an efficacious way of producing separate water and fat images with the Dixon pulse sequence. 相似文献
998.
999.
It has been postulated that the transplacental passage of maternal iron to the developing fetus requires binding of maternal transferrin to the trophoblast. We have therefore examined the ability of the human placenta to bind transferrin in vitro. Transferrin was demonstrated on trophoblast of human chorionic villi by immunohistologic methods. Moreover, after removal of transferrin bound in vivo by treatment of tissue with chaotropic solution or phosphate-buffered saline, freshly added transferrin was shown to bind in vitro in the same characteristic distribution. These findings suggest that placental iron transport is initiated by uptake of maternal transferrin iron to specific trophoblast binding sites. 相似文献
1000.