双氢埃托啡的燐光测定法及其应用

用药物—染料生成复合物的原理,建立了双氢埃托啡的燐光分析法?椒槊?可检测2ng。适用于动物血药、脑药分析。兔im0.1,0.2,1mg/kg双氢埃托啡后1与5min。血药,脑药与剂量成比例关系,其回归方程为:血药:Y=100.6X+17.73(1min), Y=367.8X+4.34(5min); 脑药:Y=5363 X+275.4(1 min),Y=6084 X+1022(5 min) 式中Y=药物浓度(ng/ml血或ng/g脑),X=双氢埃托啡剂量(mg/kg)。     

Uptake of technetium-99m hexamethylpropylene amine oxime labelled white cells in lymph nodes involved in non-Hodgkin's lymphoma

Radiolabelled white cell scanning is widely used to detect the presence of infection. We present a case of non-Hodgkin's lymphoma manifesting with signs and symptoms suggestive of infection, in which a technetium-99m hexamethylpropylene amine oxime (^99mTc-HMPAO) white cell scan demonstrated high uptake in lymph nodes involved by lymphoma. Differential cell analysis showed preferential lymphocyte labelling. The classification and management of the disease were changed accordingly. Our findings suggest that a future role for^99mTc-HMPAO labelled white cells in the assessment of disease activity of lymphoma should be investigated.     

Attempted cessation of heroin use among men approaching mid-life

Aims: To analyse the reasons for ceasing or continuing heroin use in mid-life and examine the contribution of drug treatment and social factors to this process. Methods: A semi-structured qualitative interview discussing drug-using history was conducted with Glasgow men who had previously received treatment for drug problems. Findings: Successful cessation occurred after repeated attempts and repeated treatments, often in the context of major life changes. Relapse occurred because of quitting without adequate mental preparation; returning to old haunts and life circumstances, life difficulties, the tedium of a life without heroin, and inability to cope with normal emotions previously blocked by heroin use. Men's lives could be understood as a set of tensions between the deviant subculture of heroin injecting and the conventional neighbourhood. The balance of these tensions affected men's behaviour and generally there needed to be both a push away from the subculture and a pull towards the neighbourhood for long-term cessation to occur. Conclusions: Treatment of heroin dependence may be better regarded as the management of a chronic problem, rather than as a single intervention with a quantifiable outcome. Treatment needs to consider both the benefits and problems of heroin use and the benefits and problems of conventional living.