全文获取类型
收费全文 | 5355篇 |
免费 | 187篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 183篇 |
妇产科学 | 291篇 |
基础医学 | 317篇 |
口腔科学 | 329篇 |
临床医学 | 412篇 |
内科学 | 1263篇 |
皮肤病学 | 58篇 |
神经病学 | 373篇 |
特种医学 | 241篇 |
外科学 | 1147篇 |
综合类 | 67篇 |
预防医学 | 103篇 |
眼科学 | 222篇 |
药学 | 164篇 |
中国医学 | 3篇 |
肿瘤学 | 240篇 |
出版年
2024年 | 2篇 |
2023年 | 33篇 |
2022年 | 54篇 |
2021年 | 125篇 |
2020年 | 79篇 |
2019年 | 88篇 |
2018年 | 107篇 |
2017年 | 111篇 |
2016年 | 180篇 |
2015年 | 198篇 |
2014年 | 237篇 |
2013年 | 307篇 |
2012年 | 411篇 |
2011年 | 380篇 |
2010年 | 236篇 |
2009年 | 210篇 |
2008年 | 381篇 |
2007年 | 472篇 |
2006年 | 426篇 |
2005年 | 427篇 |
2004年 | 384篇 |
2003年 | 250篇 |
2002年 | 281篇 |
2001年 | 39篇 |
2000年 | 11篇 |
1999年 | 15篇 |
1998年 | 16篇 |
1997年 | 15篇 |
1996年 | 15篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1989年 | 5篇 |
1988年 | 2篇 |
1987年 | 7篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1963年 | 1篇 |
排序方式: 共有5580条查询结果,搜索用时 31 毫秒
41.
42.
43.
44.
45.
Mustafa Girgin Burhan Hakan Kanat Refik Ayten Ziya Cetinkaya Zekiye Kanat Ahmet Bozda? Ahmet Turkoglu Yavuz Selim Ilhan 《International surgery》2012,97(4):288-292
Pilonidal disease has been treated surgically and by various other methods for many years. The most important problem associated with such treatment is recurrence, but cosmetic outcome is another important issue that cannot be ignored. Today, crystallized phenol is recognized as a treatment option associated with good medical and cosmetic outcomes. We hypothesized that the addition of laser depilation to crystallized phenol treatment of pilonidal disease might increase the rate of success, and this study aimed to determine if the hypothesis was true. Patients who were treated with crystallized phenol and 755-nm alexandrite laser depilation were retrospectively analyzed. In total, 42 (31 male and 11 female) patients were treated with crystallized phenol and alexandrite laser depilation and were followed up between January 2009 and January 2012. In all, 38 patients (90.5%) had chronic disease and 4 (9.5%) had recurrent disease. Among the patients, 26 (61.9%) recovered following 1 crystallized phenol treatment, and the remaining patients had complete remission following repeated treatment. Some patients needed multiple treatments, even up to 8 times. None of the patients had a recurrence during a mean 24 months (range, 6–30 months) of follow-up. Whatever method of treatment is used for pilonidal disease, hair cleaning positively affects treatment outcome. The present results support the hypothesis that the addition of laser depilation (which provides more permanent and effective depilation than other methods) to crystallized phenol treatment (a non-radical, minimally invasive method associated with very good cosmetic results) can increase the effectiveness of the treatment and also reduce the recurrence rate of the disease. 相似文献
46.
47.
Gokhan Koca Hakan Ozsoy Hasan Ikbal Atilgan Koray Demirel Veysel Ercan Dincel Meliha Korkmaz 《Nuclear Medicine and Molecular Imaging》2012,46(3):215-217
After surgical therapy of diffuse pigmented villonodular synovitis (DPVNS), recurrence is seen in almost half of the patients. The effectiveness of radiosynovectomy (RSV) in preventing recurrence and complaints of DPVNS is well known. Elbow involvement in DPVNS is a very rare condition; therefore, RSV in elbow hasn’t been experienced widely. The aim of this case report is to show the effectiveness of RSV with rhenium-186 (Re-186) sulfide colloid. We applied Re-186 sulfide colloid to the elbow joint of DPVNS patients six weeks after arthroscopic synovectomy. As a result, the patient did not have any complaints, and our findings are compatible with residue or recurrence on magnetic resonance imaging (MRI) in sixth and twentieth month controls after administration. We concluded that Re-186 is an effective adjuvant therapy for the prevention of recurrence and complaints. 相似文献
48.
Yüksel KAYA Ay?egül ?EB? Nihat S?YLEMEZ Halit DEM?R Hamit Hakan ALP Ebubekir BAKAN 《International journal of medical sciences》2012,9(8):621-626
The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated.Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2''-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD by colorimetric approach in blood samples obtained from patients with CAD were unraveled.8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level in serum of CAD patients compared to control group. The SOD activity was observed in stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in patients with CAD than the controls.The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and GPX activity, while the significant negative correlation was seemed between the ratio of 8-OHdG/dG and ubiquinol-10/ ubiquinone-10 as well as MDA levels and ubiquinol-10/ ubiquinone-10 ratio.We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of coronary artery disease. 相似文献
49.
Akdemir R Ozhan H Yazici M Gunduz H Duran S Gurel C Ozdas S Uyan C Basar I Ulutin T 《Heart and vessels》2004,19(4):167-171
The angiotensin II receptor, losartan, has been found to inhibit platelet aggregability to some extent in in vitro experiments. There have been conflicting results about the in vivo effects of losartan. We sought to clarify the in vivo effect of losartan on platelet aggregation. Forty patients with grade I essential hypertension were treated with losartan for 3 weeks. Platelet aggregation tests with adenosine diphosphate (ADP) and ristocetin were analyzed and compared before and at the end of the study. Losartan effectively decreased systolic (SBP) and diastolic (DBP) blood pressure. Mean SBP before and after treatment was 159.6 ± 12.8 and 149.2 ± 17.3mmHg, respectively. Mean DBP decreased from 93.7 ± 8.2 to 87.7 ± 10.3mmHg after treatment. The results of the platelet aggregation tests with ADP and ristocetin were not significantly different when both rate and amplitude of maximal aggregation were included. Peak platelet aggregation with ADP regarding the lowest light transmission in the aggregometer was 59.8% ± 24.3% before and 58.3% ± 18.1% after the treatment. The same variables with ristocetin were 66.8% ± 21.6% and 60.8% ± 23.3%, respectively. In vivo effects of losartan on platelet aggregation with ADP and ristocetin were insignificant. 相似文献
50.
Ilknur I Bütün Hakan Ekmek?i Hüseyin S?nmez Ci?dem Gürel Ozlem Cift?i Turgut Ulutin Emine K?ko?lu Nergiz Domani? Ahmet Dirican 《Clinical and applied thrombosis/hemostasis》2007,13(3):308-312
Several studies indicate that thrombosis plays an important role in the pathogenesis of coronary heart disease (CHD). Fibronectin is a multifunctional protein in plasma, other body fluids, and cell surface and plays an important role in platelet functions, including mediation of cell-cell and cell-surface interactions. Sialic acid is a regular constituent of glycoproteins and gangliozides in the outer cell membrane of mammalian cells. Therefore, the sialic acid content of platelets, which are characterized by their ability to aggregate with each other, can be important in leading to thrombus formation. In this study, platelet fibronectin, sialic acid-, and adenosine diphosphate (ADP)-induced platelet aggregation levels were determined in patients with CHD. Platelet sialic acid concentrations were determined by Warren's method. Platelet aggregation tests with ADP in platelet-rich plasma (PRP) were analyzed by use of an aggregometer. Platelet homogenate fibronectin levels were determined by ELISA. Total protein levels were determined by Lowry method. Our results indicate that, in patients with no vessel disease (patients with no obstructed vessel but suffering from chest pain, like angina pectoris) platelet fibronectin levels were significantly lower than the total of the other patients (patients with 1, 2, or 3 obstructed coronary vessels) (p<0.05). Sialic acid levels in patients with no vessel disease were significantly lower than the total of the patient group (p<0.05). There was significant (+) correlation between platelet aggregation, platelet fibronectin, platelet sialic acid, and severity of disease (p<0.05). Our preliminary findings suggest that, especially platelet fibronectin levels potentially represent a pathogenic factor for CHD. 相似文献