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Rashi Jain Rinkee Kumari Sushmita Chakraborty Dipendra K. Mitra Anant Mohan Vijay Hadda Karan Madan Randeep Guleria 《European journal of immunology》2023,53(10):2250255
Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration due to mononuclear phagocytes and lymphocytes and associated noncaseating granuloma formation. Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and histopathological characteristics with that of pulmonary tuberculosis (PTB). Due to this, clinicians face issues in differentiating between PS and PTB in a substantial number of cases. There is a lack of any specific biomarker that can diagnose PS distinctively from PTB. We compared T-cell-based signature cytokines in patients with PS and PTB. In this study, we proposed a serum biomarker panel consisting of cytokines from cells: T helper (Th) 1 [interferon-gamma (IFN-γ); tumor necrosis factor-alpha (TNF-α)], Th9 [interleukin (IL)-9], Th17 [IL-17], and T regulatory (Treg) [IL-10; transforming growth factor-beta (TGF-β)]. We performed the principal component analysis that demonstrated that our serum cytokine panel has a significant predictive ability to differentiate PS from PTB. Our results could aid clinicians to improve the diagnostic workflow for patients with PS in TB endemic settings where the diagnosis between PS and PTB is often ambiguous. 相似文献
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Prashant Nasa Dhruva Chaudhry Deepak Govil Mradul K Daga Ravi Jain Akshaykumar A Chhallani Apoorv Krishna Bharat G Jagiasi Deven Juneja Himadri S Barthakur Hrishikesh Jha Mohan Gurjar Pradeep Rangappa Raghunath Aladakatti Rajesh C Mishra Rajesh M Shetty Rohit Yadav Sandeep Garg Sivakumar M Nandakumar Srinivas Samavedam Sumit Ray Vijay Hadda Yash Javeri Manish Munjal 《Indian Journal of Critical Care Medicine》2021,25(11):1280
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Hadda V. E. Mertens H. Brach Biedermann 《Journal of cancer research and clinical oncology》1931,34(5):145-148
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Werthemann Hadda V. E. Mertens Haagen 《Journal of cancer research and clinical oncology》1931,34(2-3):33-34
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V. E. Mertens Colmers Hadda Werthemann H. Brach 《Journal of cancer research and clinical oncology》1931,34(6):218-219
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F. Fetscher Hadda und V. E. Mertens 《Journal of cancer research and clinical oncology》1929,29(1):2-3
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