NSCLC组织中β-微管蛋白Ⅲ、stathmin蛋白表达变化及意义

目的观察非小细胞肺癌（NSCLC）组织中的stathmin、β-tubulinⅢ,并探讨其与紫杉醇化疗疗效的的关系。方法采用免疫组化SP法检测123例NSCLC患者肿瘤组织（观察组）和15例炎性假瘤患者瘤组织（对照组）中的stathmin、-βtubulinⅢ,并对其中行根治术后用紫杉醇类药物行辅助化疗的32例NSCLC患者的疗效进行分析。结果 NSCLC组织中stathmin、-βtubulinⅢ蛋白表达阳性率分别为52.8%、62.6%,显著高于良性对照组的6.7%、13.3%（P均〈0.05）。stathmin蛋白均在低分化和有淋巴转移的肿瘤中表达明显升高（P均〈0.05）;-βtubu linⅢ蛋白在低分化和Ⅲ~Ⅳ期肿瘤中表达明显升高（P均〈0.05）。32例术后用含紫杉醇化疗方案化疗的患者中,stath-min、-βtubulinⅢ蛋白表达全阳性者的生存率较全阴性者低（P〈0.05）。结论 NSCLC患者肿瘤组织中stathmin、β-tubulinⅢ蛋白均明显升高。二者表达均阳性预示着肿瘤的恶性程度较高,对紫杉醇类化疗药物的敏感性较差,术后预后较差。     

磁共振诊断卵巢纤维卵泡膜细胞瘤一例

正病例:患者,女,74岁,因下腹部坠胀6天入院。查体:腹部膨隆,其余未见明显异常。妇科检查:子宫呈老年性萎缩,子宫前方触及一实性包块,直径约13 cm,表面光滑,活动度一般,压痛(+);附件触及不理想。糖类抗原125199.60 U/ml,血液及其他实验室检查无异常。本院彩超示盆腔内实性包块,大小约为102 mm×129 mm×89 mm。磁共振检查:盆腔及腹腔内见巨大包块,T1WI信号略低于子宫肌层,内见斑点状高信号影(图1A),T2WI呈高、低混杂信号(图1B),弥散加权     

前列腺结核误诊为前列腺癌1例

病例男,54岁.2年前无明显诱因出现排尿困难,伴尿频、尿痛,无肉眼血尿,无发热,未行任何治疗.2年来上述症状持续存在,近1周加重,伴血尿.否认既往结核病史.人院查体:生命体征正常,营养中等,心肺未见异常.专科情况:外生殖器发育正常,睾丸、附睾末触及结节.肛诊:前列腺Ⅰ度,表面不光滑,质硬,触痛明显.实验室检查:血常规正常;血液总前列腺特异性抗原(T-PSA):2.03Ng/ml;肝肾功能正常.胸部X片:未见异常.尿路IVP+KUB双肾及肾盂未见异常.     

247. H?modynamische Charakteristika der akut nekrotisierenden Pankreatitis

Zusammenfassung Bei 23 Patienten mit nekrotisierender Pankreatitis wurden hämodynamische Messungen mit einem Swan-Ganz-Katheter vorgenommen. Der mittlere arterielle Druck war signifikant erniedrigt, die Herzfrequenz dagegen erhöht. Charakteristisch war für alle Patienten ein niedriger peripherer Gefäßwiderstand und ein erhöhtes Herz-Zeit-Volumen sowie ein erhöhter Kardiac-Index. Patienten mit nekrotisierender Pankreatitis haben also einen hyperdynamischen Schockzustand, wie er auch im septischen Schock beobachtet wird.     

两种不同基质环丙沙星栓在家兔体内的药物动力学研究

研制了两种不同基质的环内沙星栓剂，并对其在家兔体内的药物动力学与市售片剂进行了比较。实验表明，两种栓剂的Ｃ＿（ＰＫ），ＡＵＣ值等均明显高于片剂（ｐ＜０．００１），预示可以通过改变给药途径提高环丙沙星的生物利用度。     

Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans

The relationship between plasma iron, transferrin saturation, and plasma iron turnover was studied in 53 normal subjects whose transferrin saturation varied between 17% and 57%, in 25 normal subjects whose transferrin saturation was increased by iron infusion to between 67% and 100%, and in five subjects with early untreated idiopathic hemochromatosis whose transferrin saturation was continually elevated to between 61% and 86%. The plasma iron turnover of all of these subjects ranged from 0.45 to 1.22 mg/dL whole blood/d. The mean values for the above-mentioned three groups were 0.71 +/- 0.17, 1.01 +/- 0.11, and 1.01 +/- 0.13 mg/dL whole blood/d, respectively. Most of this variation, estimated at 72% by regression analysis, was due to a direct relationship between transferrin saturation and plasma iron turnover. This effect was attributed to a competitive advantage of diferric over monoferric transferrin in delivering iron to tissues. This was confirmed by the demonstration of a more rapid clearance of diferric as compared to monoferric transferrin in an additional group of eight normal subjects. Calculations were made of the amount of transferrin reacting with membrane receptors per unit time. Allowance was made for the noncellular (extravascular) exchange and for the 4.2:1 preference of diferric over monoferric transferrin demonstrated in vitro. The amount of iron-bearing transferrin leaving the plasma to bind to tissue receptors for 53 subjects with a transferrin saturation between 17% and 57% was 71 +/- 13; for 25 subjects with a saturation from 67% to 100%, 72 +/- 12; and for five subjects with early idiopathic hemochromatosis, 82 +/- 11 mumol/L whole blood/d. There were no significant differences among these groups. These studies indicate that while the number of iron atoms delivered to the tissues increases with increasing plasma iron and transferrin saturation, the number of iron-bearing transferrin molecules that leave the plasma per unit time to bind to tissue receptors is relatively constant and within the limits studied, independent of transferrin saturation.     

Hepatic falciform artery: anatomy, angiographic appearance, and clinical significance

Three patients developed supraumbilical skin rashes during hepatic artery infusion chemotherapy by a surgically placed perfusion catheter and drug-infusion pump. In one patient, hepatic arterial scintigraphy with technetium-99m macroaggregated serum albumin showed increased uptake corresponding to the rash, and a hepatic arteriogram showed a dilated falciform branch of the left hepatic artery. Surgical ligation of the falciform artery permitted further treatment without recurrent rash. Based on a review of 100 celiac arteriograms, the incidence of the falciform artery on angiographic studies is approximately 2%. The angiographic appearance of this artery is presented, and its potential clinical significance in hepatic artery perfusion chemotherapy is discussed.