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741.
CRM Lammens EMA Bleiker S Verhoef FJ Hes MGEM Ausems D Majoor‐Krakauer RH Sijmons RB Van Der Luijt AMW Van Den Ouweland Tam Van Os N Hoogerbrugge EB Gómez García CJ Dommering CM Gundy NK Aaronson 《Clinical genetics》2010,77(5):483-491
Lammens CRM, Bleiker EMA, Verhoef S, Hes FJ, Ausems MGEM, Majoor‐Krakauer D, Sijmons RH, Luijt van der RB, Ouweland van den AMW, Van Os Tam, Hoogerbrugge N, Gomez‐Garcia EB, Dommering CJ, Gundy CM, Aaronson NK. Psychosocial impact of von Hippel–Lindau disease: levels and sources of distress. Von Hippel–Lindau disease (VHL) is a hereditary tumor susceptibility syndrome, characterized by an increased risk of developing multiple benign and malignant tumors at various sites and ages with limited preventive options. This study evaluates the prevalence of distress among VHL family members and factors associated significantly with such distress. Forty‐eight families with a VHL mutation were identified via the nine family cancer clinics in the Netherlands. In total, 171 family members (carriers, 50% at‐risk, non‐carriers) were approached, of whom 123 (72%) completed a self‐report questionnaire. Approximately 40% of the VHL family members reported clinically relevant levels of distress, approaching 50% among the carriers and, possibly even more striking, 36% among the non‐carriers. Having lost a first degree relative due to VHL during adolescence (OR 11.2; 95% CI 1.4–86.9) was related significantly to heightened levels of distress. Approximately, only one‐third of those who reported heightened levels of distress had received professional psychosocial support. A substantial percentage of family members experience clinically relevant levels of distress. We would recommend the introduction of a procedure for screening for distress in this vulnerable population. Special attention should be paid to those individuals who have lost a close relative due to VHL during adolescence. 相似文献
742.
743.
M. Swathika Kshitij RB Singh M. Mehala Sadanand Pandey Jay Singh Ravindra Pratap Singh Arunadevi Natarajan 《RSC advances》2022,12(23):14888
In the present work, we evaluated the corrosion inhibition properties of a ligand and mixed metal oxide nanocomposite. The ligand and mixed nickel–cobalt complex were synthesized using 1-naphthoic acid and aminoguanidine with the formulae [C11H7O2(CN4H5)(CN4H6)]·H2O and {Ni–Co[(CH5N4)2(C11H7O2)2]}·H2O, respectively. After their synthesis, physicochemical techniques such as CHNS analysis, infrared and UV-visible spectroscopy, thermal analysis, and X-ray diffraction (XRD) were employed to characterize both the synthesized ligand and nickel–cobalt complex. The metal oxide prepared from the decomposition of the metal complex was also characterized using several techniques to confirm its bonding and structure. In addition, the corrosion inhibition efficiency of the epoxy-ligand and epoxy-NiCo2O4 nanocomposite on mild steel (MS) in 3 M hydrochloric acid (HCl), 1.5 M sulfuric acid (H2SO4), and 0.5 M phosphoric acid (H3PO4) solution was examined and compared using weight loss measurements, Tafel plots, isotherms and electrochemical impedance spectroscopy (EIS). The results from the electrochemical studies disclosed that the epoxy coating of mixed metal oxides with 0.8 ppm concentration yielded excellent corrosion protection. The SEM images of mild steel and mild steel coated with epoxy-ligand/epoxy-NiCo2O4 in HCl confirmed the anti-corrosive behavior of the synthesized compounds. Hence, the as-prepared material can be a next-generation tool for sustainable anti-corrosive coatings.This study reports the synthesis of nano-sized epoxy-NiCo2O4 nanocomposites and their anti-corrosive efficiency to attain sustainable development. 相似文献