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321.
Cagdas Eker Omer Kitis Fatma Taneli Ozlem Donat Eker Erol Ozan Kaan Yucel Kerry Coburn Ali Saffet Gonul 《European archives of psychiatry and clinical neuroscience》2010,260(7):527-533
The hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis
within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed
patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF)
levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 ± 9.3) and healthy
controls (17 female, 5 male; mean age = 29.7 ± 6.4). Region of interest analysis was conducted on the images acquired via
MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent
as severe and multiple episodes are experienced. 相似文献
322.
323.
Visual and oculomotor signs and symptoms are common and well defined in patients with multiple sclerosis. On the other hand, the phenomenon of "upside-down" reversal of vision is very rare and thus not well known. The physiopathology of this phenomenon also has not been well understood. Herein, we present a female patient with multiple sclerosis, who developed acute "upside-down" visual inversion, and discuss possible mechanisms of this rare phenomenon. 相似文献
324.
Polat F Demirel SO Kitis O Simsek F Haznedaroglu DI Coburn K Kumral E Gonul AS 《Current Alzheimer research》2012,9(7):789-794
In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched cognitively normal elderly were analyzed with voxel-based morphometry and classified by support vector machine (SVM), a machine learning technique. SVM could differentiate patients from controls with accuracy of 74 % (sensitivity: 70 % and specificity: 77 %) when the whole brain was included the analyses. The classification accuracy was increased to 79 % (sensitivity: 65 % and specificity: 93 %) when the analyses restricted to hippocampus. Our results showed that SVM is a promising tool for diagnosis of AD, but needed to be improved. 相似文献
325.
Cervical lipomyelomeningocele is a rare congenital spinal pathology. Lipomyelomeningocele is the commonest cause of congenital tethering, which causes neurological deterioration due to the conus medullaris and root ischemia. Early intervention is recommended even in cases with normal neurological examinations in order to prevent deterioration but our patient with cervical lipomyelomeningocele had a normal neurological examination despite his age (22 year-old) and had no urodynamic dysfunction. 相似文献
326.
327.
Senay Savas Erdeve Zehra Aycan Merih Berberoglu Zeynep Siklar Bulent Hacıhamdıoglu Kadir Sıpahı Nejat Akar Gonul Ocal 《European journal of pediatrics》2010,169(8):991-995
Molecular genetic characterization of mutations in SRD5A2 gene is used as an essential procedure for the final diagnosis of 5α-reductase deficiency. Here, we report a novel homozygous
point mutation of SRD5A2 gene at codon 65 in exon 1, due to a proline for alanine substitution in a Turkish family whose proband has severe undervirilization.
This mutation has not been reported up to date in association with 5α-reductase deficiency in various ethnic groups. We discussed
some questions about gender assignment in addition to the molecular and clinical characteristics of the disease. 相似文献
328.
Caner Aytekin Manuela Germeshausen Nilden Tuygun Gonul Tanir Figen Dogu Aydan Ikinciogullari 《European journal of pediatrics》2010,169(6):657-660
Rolf Kostmann (1909–1982) was a Swedish pediatrician and army doctor. He was the first to describe an inherited form of chronic neutropenia in childhood. In 1956, Kostmann published his article “Infantile genetic agranulocytosis” in Acta Paediatrica. “Infantile agranulocytosis,” as Rolf Kostmann named this hereditary syndrome, has been known for more than half a century, yet the underlying genetic mutations have remained unknown for many decades. Fifty years later, homozygous mutations in the gene encoding the mitochondrial protein HCLS1-associated X1 were found in affected members of the original Kostmann pedigree. Therefore, the eponym “Kostmann disease” best fits this specific mutation and mode of inheritance. The identification of genetic cause now allows the analysis of genotype–phenotype correlations. After the development of recombinant human granulocyte colony-stimulating factor (G-CSF), the prognosis and quality of life improved dramatically. Hematopoietic stem cell transplantation remains the only currently available treatment for refractory cases to G-CSF and patients who have transformed into leukemia. 相似文献
329.
Yucel Gonul Ahmet Songur Ibrahim Uzun Ramazan Uygur Ozan Alper Alkoc Veli Caglar Hudaverdi Kucuker 《Surgical and radiologic anatomy : SRA》2014,36(7):651-661
Background
The cerebral sulci are known as main microanatomical borders that serve as a gateway and surgical passage to reach the ventricles or to the deeper lesions. It is a matter of curiosity that whether there is a convergence between the morphological asymmetry and the functional asymmetry, and also its significance in surgery. The aim of this study is make morphometric measurements and evaluate asymmetry of several sulci on the lateral aspects of the cerebrum in regard to main sulci and related reference key points.Methods
A total of 100 cerebral hemispheres from 50 autopsy cadavers were examined. The lengths of several sulci on the superolateral aspect of the hemispheres and the distances between the sulci and nearby sulci and the reference key points were measured. Encountered variations were examined and photographed.Results
Evaluation of the variations: superior frontal sulcus (SFS), inferior frontal sulcus, superior temporal sulcus (STS), precentral sulcus and postcentral sulcus were found to be discontinuous in 60, 46, 41, 84 and 70 % of the hemispheres, respectively. Evaluation of the asymmetry: the distances between SFS posterior end and longitudinal fissure, STS posterior end and lateral sulcus posterior end, as well as lengths of external occipital fissure (EOF), and discontinuous course of STS were significantly different between left and right hemispheres.Conclusions
There is usually a morphological partial asymmetry between the right and left hemispheres for any individual. Also, some of our measurements were found to be compatible with the ones in the literature, while others were incompatible. 相似文献330.
Hadim Akoglu Fatih Dede Ipek Isik Gonul Serhan Piskinpasa Ali Riza Odabas 《Journal of the National Medical Association》2010,102(3):247-249
We report a patient with medullary sponge kidney (MSK) who presented with hematuria and nephrotic-range proteinuria. Renal biopsy revealed a diagnosis of renal AA amyloidosis. No secondary factors contributing to renal amyloidosis were demonstrated. To the best of our knowledge, this is the first reported case that demonstrates the coexistence of MSK and renal AA amyloidosis. 相似文献