2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用

作者曾报道2,4-二氨基-5-甲基-6-取代苄氨基喹唑啉衍生物有较好的抗疟和抗肿瘤作用。鉴于在2,4-二氨基-6-取代苄氨基喹唑啉的6位侧链氨基上引入甲基,可使抗肿瘤活性明显增强,因此设计合成了一系列2,4-二氨基-5-甲基-6-(N-甲基取     

2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用

This paper reports four methods for the synthesis of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done.     

Giant esophageal polyp: a clinical and radiological entity with variable histology

Giant pedunculated esophageal polyps are very rare. They may stay asymptomatic for a long time, and first come to the attention of the patient and the clinician after regurgitation into the mouth. Regurgitation, however, can be dangerous and has been known to lead to asphyxia and death due to closure of the larynx by the polyp mass. For this reason resection of the giant polyp is essential when it is discovered. We have seen four cases of giant esophageal polyps (GEP) at our institution. All four patients have undergone removal of the giant polyps. The histological diagnoses were fibrovascular polyp, liposarcoma, hamartoma and multiple lipomas. The mode of clinical presentation, radiological appearances, variable histological diagnoses, and therapy options in these four patients are presented along with a review of the literature. Received 4 March 1997; Revision received 13 June 1997; Accepted 15 July 1997     

Iron Deficiency Anaemia and Severe Thrombocytosis in a Case of Disseminated Abdominal Canine Cryptococcosis

A 7-year-old female cross-breed dog presented with a non-regenerative anaemia. Disseminated intra-abdominal cryptococcosis was diagnosed by ultrasound-guided fine needle aspiration cytology. Complete blood count and bone marrow cytology revealed microcytic hypochromic iron-deficiency anaemia and severe thrombocytosis (>1 million platelets/ml). Post-mortem examination and histopathology confirmed the diagnosis and revealed multiple organ involvement. Both gastrointestinal lesions and absence of respiratory tract cryptococcal granulomas suggest an oral instead of nasal infection route.     

Experimental evaluation of various available contrast agents for use in the upper gastrointestinal tract in case of suspected leakage: effects on mediastinum

The tissue reaction of seven contrast agents--pure barium sulphate, Micropaque, Hytrast, Dionosil, Gastrografin, Amipaque and Hexabrix-was evaluated on the mediastinum of rats. This work was undertaken to define the most suitable and safe contrast agent for use in the upper gastrointestinal tract in cases where leakage outside the gut into the mediastinum, pleura or peritoneal cavity may be suspected and aspiration may be an accompanying risk. Keeping in mind the danger of aspiration, Hexabrix and Amipaque appear to be the safest contrast media for the mediastinum.     

Experimental evaluation of various available contrast agents for use in the upper gastrointestinal tract in case of suspected leakage. Effects on lungs

The reactions of seven contrast agents--pure barium sulphate, Micropaque, Gastrografin, Dionosil, Hytrast, Amipaque and Hexabrix--on the bronchi and lungs of rats were studied. This work was undertaken to find a safe gastrointestinal contrast agent for use in post-operative patients where aspiration may be an accompanying risk. Amipaque and Hexabrix produced no significant histological reaction in the lungs and would, therefore, appear to be suitable for use in such cases.