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Breath-hold, contrast-enhanced, three-dimensional MR angiography 总被引:22,自引:0,他引:22
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Women worried about their familial breast cancer risk--a study on genetic advice in general practice
de Bock GH; Perk DC; Oosterwijk JC; Hageman GC; Kievit J; Springer MP 《Family practice》1997,14(1):40-43
AIMS: To ascertain whether women who consulted their GP because they
perceived themselves as at increased risk of familial breast cancer were
indeed at increased risk, and to evaluate potential strategies for
assessing genetic risk of breast cancer in general practice. METHODS:
Sixty-seven out of 81 women who had consulted their GP for advice about
their possible increased risk of developing breast cancer due to breast
cancer in the family were interviewed. Familial breast cancer risk was
assessed by a clinical geneticist. This assessment was compared with two
recent guidelines for referral for genetic counselling. RESULTS: More than
half (52%; n = 35) the women had a relative risk of two and over for
developing breast cancer, while another half of these 35 (25%; n = 17) had
a relative risk of three and over. All the women (n = 17) with a relative
risk of three and over were identified by means of the two current
guidelines for referral for genetic counselling, while more than half of
the women (61%; n = 11) with a relative risk between two and three were
identified. CONCLUSIONS: More than half the women concerned about their
familial risk of breast cancer are indeed at increased risk of breast
cancer. Current guidelines correctly identify women at high risk. However,
doubts about the health gain and feasibility of referral warrant caution,
and need further investigation.
相似文献
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Spinning top urethra (STU) is a term used to describe a widened posterior urethra seen mainly in girls. It is commonly regarded as a normal variant. The authors studied 30 girls with STU using videourodynamics. Twenty-eight showed bladder instability; 21, a congenital wide bladder neck anomaly; and 20, both instability and a wide bladder neck. One patient had a sensitive bladder. All patients had a urodynamic abnormality. The authors believe that the STU is nearly always an indication of bladder instability or wide bladder neck anomaly. The most common mechanism for the dilatation of the posterior urethra is that unstable contractions are resisted by a voluntary increase in distal sphincter tension so as to prevent leakage of urine. The resulting pressure rise produces distention of the posterior urethra, which will be maximal in subjects with a weak bladder neck mechanism as in the congenital wide bladder neck anomaly. The authors believe that STU is seldom if ever a normal variant. 相似文献
38.
Measurements of T1 and T2 relaxation values and spin density of the lumbar vertebral bone marrow were performed in 212 patients, and the results were correlated with the patients' age and sex. T1 and T2 relaxation times for bone marrow in the lumbar vertebral bodies showed a progressive decrease with age for both sexes (except for the T2 relaxation values in female patients). The replacement of hematopoietic marrow by fatty marrow could explain the decrease in T1 and T2. The T1 and T2 values were in the same range for the first two age groups (age 1-10 years and age 21-40 years) and became slightly greater for the older female patients (age 51 years and older) than for the older males. This could be due to the loss of bone and mineral content, which is more rapid and significant for women. These normal T1 and T2 values may provide a baseline for future evaluation of diseases involving the lumbar spine. 相似文献
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