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41.

Synthesis and Neurotropic Activity of New 7-Cyclohexyl-6,7,8,9-Tetrahydro-3<Emphasis Type="Italic">H</Emphasis>-Pyrazolo[3,4-<Emphasis Type="Italic">c</Emphasis>]-2,7-Naphthyridine-1,5-Diamines

S. N. Sirakanyan E. K. Hakobyan A. G. Nikoghosyan R. G. Paronikyan I. A. Dzhagatspanyan I. M. Nazaryan A. G. Akopyan A. A. Hovakimyan 《Pharmaceutical Chemistry Journal》2018,52(2):108-111

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42.

Analgesic Activity of a Polypeptide Modulator of TRPV1 Receptors

I. A. D’yachenko G. I. Belous L. A. Skobtsova T. Yu. Zharmukhamedova V. A. Palikov Yu. A. Palikova E. V. D’yachenko E. A. Kalabina V. B. Rudenko Ya. A. Andreev Yu. A. Logashina S. A. Kozlov A. N. Yavorskii A. N. Murashev 《Pharmaceutical Chemistry Journal》2018,52(3):213-215

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43.

Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles

R. I. Ishmetova S. G. Tolshchina N. K. Ignatenko M. A. Kravchenko S. N. Skornyakov G. L. Rusinov V. N. Charushin 《Pharmaceutical Chemistry Journal》2018,52(4):304-307

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44.

Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones

L. V. Anikina A. V. Semakov S. V. Afanas’eva S. A. Pukhov S. G. Klochkov 《Pharmaceutical Chemistry Journal》2018,52(4):308-311

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45.

Synthesis and Antimicrobial Activity of 5-(Arylmethylidene)-2,4,6-Pyrimidine-2,4,6(1<Emphasis Type="Italic">H</Emphasis>,3<Emphasis Type="Italic">H</Emphasis>,5<Emphasis Type="Italic">H</Emphasis>)-Triones

S. A. Luzhnova A. G. Tyrkov N. M. Gabitova E. A. Yurtaeva 《Pharmaceutical Chemistry Journal》2018,52(6):506-509

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46.

Synthesis and Analgesic,Anthelmintic, and Insecticidal Activity of 3,3-Dialkyl-1-(2-Phenylamino-2-Thioxoethyl)-3,4-Dihydroisoquinolinium Chlorides

A. G. Mikhailovskii A. S. Yusov R. R. Makhmudov A. V. Starkova I. P. Rudakova 《Pharmaceutical Chemistry Journal》2018,52(8):716-720

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47.

Applicability of an Alternative Method for Sterility Testing of Medicinal Preparations

M. V. Roshchina O. V. Gunar N. G. Sakhno 《Pharmaceutical Chemistry Journal》2018,51(11):1045-1048

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48.

A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets

Marin D. E. Pistol G. C. Gras M. Palade M. Taranu I. 《Naunyn-Schmiedeberg's archives of pharmacology》2018,391(10):1147-1156

Naunyn-Schmiedeberg's Archives of Pharmacology - Ochratoxin A (OTA) and aristolochic acid (AA) are toxins that can frequently contaminate cereals and cereals-based products. The present study... 相似文献

49.

Increased Efficacy and Safety of Enteral Nutrition Support with a Protocol (ASNET) in Noncritical Patients: A Randomized Controlled Trial

Luis Alfonso Ortíz-Reyes Lilia Castillo-Martínez Arianne Itzel Lupián-Angulo Daniel Dante Yeh Héctor Isaac Rocha-González Aurora Elizabeth Serralde-Zúñiga 《Journal of the Academy of Nutrition and Dietetics》2018,118(1):52-61

Background

Unintentional underfeeding is common in patients receiving enteral nutrition (EN), and is associated with increased risk of malnutrition complications. Protocols for EN in critically ill patients have been shown to enhance adequacy, resulting in better clinical outcomes; however, outside of intensive care unit (ICU) settings, the influence of a protocol for EN is unknown.

Objective

To evaluate the efficacy and safety of implementing an EN protocol in a noncritical setting.

Design

Randomized controlled clinical trial.

Participants and settings

This trial was conducted from 2014 to 2016 in 90 adult hospitalized patients (non-ICU) receiving exclusively EN. Patients with carcinomatosis, ICU admission, or <72 hours of EN were excluded.

Intervention

The intervention group received EN according to a protocol, whereas the control group was fed according to standard practice.

Main outcome measures

The proportion of patients receiving ≥80% of their caloric target at Day 4 after EN initiation.

Statistical analyses performed

Student t test or Wilcoxon rank-sum test were used for continuous variables and the difference between the groups in the time to receipt of the optimal amount of nutrition was analyzed using Kaplan-Meier curves.

Results

Forty-five patients were randomized to each group. At Day 4 after EN initiation, 61% of patients in the intervention arm had achieved the primary end point compared with 23% in the control group (P=0.001). In malnourished patients, 63% achieved the primary end point in the intervention group compared with 16% in the control group (P=0.003). The cumulative deficit on Day 4 was lower in the intervention arm compared with the control arm: 2,507 kcal (interquartile range [IQR]=1,262 to 2,908 kcal) vs 3,844 kcal (IQR=2,620 to 4,808 kcal) (P<0.001) and 116 g (IQR=69 to 151 g) vs 191 g (IQR=147 to 244 g) protein (P<0.001), respectively. The rates of gastrointestinal complications were not significantly different between groups.

Conclusions

Implementation of an EN protocol outside the ICU significantly improved the delivery of calories and protein when compared with current standard practice without increasing gastrointestinal complications. 相似文献

50.

Malnutrition Diagnosis during Adult Inpatient Hospitalizations: Analysis of a Multi-Institutional Collaborative Database of Academic Medical Centers

Conrad M. Tobert Sarah L. Mott Kenneth G. Nepple 《Journal of the Academy of Nutrition and Dietetics》2018,118(1):125-131

Background

Malnutrition is a significant problem for hospitalized patients. However, the true prevalence of reported malnutrition diagnosis in real-world clinical practice is largely unknown. Using a large collaborative multi-institutional database, the rate of malnutrition diagnosis was assessed and used to assess institutional variables associated with higher rates of malnutrition diagnosis.

Objective

The aim of this study was to define the prevalence of malnutrition diagnosis reported among inpatient hospitalizations.

Design

The University Health System Consortium (Vizient) database was retrospectively reviewed for reported rates of malnutrition diagnosis.

Participants/setting

All adult inpatient hospitalization at 105 member institutions during fiscal years 2014 and 2015 were evaluated.

Main outcome measures

Malnutrition diagnosis based on the presence of an International Classification of Diseases-Ninth Revision diagnosis code.

Statistical analysis

Hospital volume and publicly available hospital rankings and patient satisfaction scores were obtained. Multiple regression analysis was performed to assess the association between these variables and reported rates of malnutrition.

Results

A total of 5,896,792 hospitalizations were identified from 105 institutions during the 2-year period. It was found that 292,754 patients (5.0%) had a malnutrition diagnosis during their hospital stay. By institution, median rate of malnutrition diagnosis during hospitalization was 4.0%, whereas the rate of severe malnutrition diagnosis was 0.9%. There was a statistically significant increase in malnutrition diagnosis from 4.0% to 4.9% between 2014 and 2015 (P<0.01). Institutional factors associated with increased diagnosis of malnutrition were higher hospital volume, hospital ranking, and patient satisfaction scores (P<0.01).

Conclusions

Missing a malnutrition diagnosis appears to be a universal issue because the rate of malnutrition diagnosis was consistently low across academic medical centers. Institutional variables were associated with the prevalence of malnutrition diagnosis, which suggests that institutional culture influences malnutrition diagnosis. Quality improvement efforts aimed at improved structure and process appear to be needed to improve the identification of malnutrition. 相似文献

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